The amphibian peptide Yodha is virucidal for Zika and dengue viruses

Abstract Zika virus (ZIKV) has emerged as a serious health threat in the Americas and the Caribbean. ZIKV is transmitted by the bite of an infected mosquito, sexual contact, and blood transfusion. ZIKV can also be transmitted to the developing fetus in utero, in some cases resulting in spontaneous a...

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Autores principales:	Song Hee Lee, Eui Ho Kim, Justin T. O’neal, Gordon Dale, David J. Holthausen, James R. Bowen, Kendra M. Quicke, Ioanna Skountzou, Shyla Gopal, Sanil George, Jens Wrammert, Mehul S. Suthar, Joshy Jacob
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1222b054c19b4f9b953994df1b0439c9
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spelling	oai:doaj.org-article:1222b054c19b4f9b953994df1b0439c92021-12-02T14:01:19ZThe amphibian peptide Yodha is virucidal for Zika and dengue viruses10.1038/s41598-020-80596-42045-2322https://doaj.org/article/1222b054c19b4f9b953994df1b0439c92021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-80596-4https://doaj.org/toc/2045-2322Abstract Zika virus (ZIKV) has emerged as a serious health threat in the Americas and the Caribbean. ZIKV is transmitted by the bite of an infected mosquito, sexual contact, and blood transfusion. ZIKV can also be transmitted to the developing fetus in utero, in some cases resulting in spontaneous abortion, fetal brain abnormalities, and microcephaly. In adults, ZIKV infection has been correlated with Guillain–Barre syndrome. Despite the public health threat posed by ZIKV, neither a vaccine nor antiviral drugs for use in humans are currently available. We have identified an amphibian host defense peptide, Yodha, which has potent virucidal activity against ZIKV. It acts directly on the virus and destroys Zika virus particles within 5 min of exposure. The Yodha peptide was effective against the Asian, African, and South American Zika virus strains and has the potential to be developed as an antiviral therapeutic in the fight against Zika virus. The peptide was also effective against all four dengue virus serotypes. Thus, Yodha peptide could potentially be developed as a pan-therapeutic for Zika and dengue viruses.Song Hee LeeEui Ho KimJustin T. O’nealGordon DaleDavid J. HolthausenJames R. BowenKendra M. QuickeIoanna SkountzouShyla GopalSanil GeorgeJens WrammertMehul S. SutharJoshy JacobNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Song Hee Lee Eui Ho Kim Justin T. O’neal Gordon Dale David J. Holthausen James R. Bowen Kendra M. Quicke Ioanna Skountzou Shyla Gopal Sanil George Jens Wrammert Mehul S. Suthar Joshy Jacob The amphibian peptide Yodha is virucidal for Zika and dengue viruses
description	Abstract Zika virus (ZIKV) has emerged as a serious health threat in the Americas and the Caribbean. ZIKV is transmitted by the bite of an infected mosquito, sexual contact, and blood transfusion. ZIKV can also be transmitted to the developing fetus in utero, in some cases resulting in spontaneous abortion, fetal brain abnormalities, and microcephaly. In adults, ZIKV infection has been correlated with Guillain–Barre syndrome. Despite the public health threat posed by ZIKV, neither a vaccine nor antiviral drugs for use in humans are currently available. We have identified an amphibian host defense peptide, Yodha, which has potent virucidal activity against ZIKV. It acts directly on the virus and destroys Zika virus particles within 5 min of exposure. The Yodha peptide was effective against the Asian, African, and South American Zika virus strains and has the potential to be developed as an antiviral therapeutic in the fight against Zika virus. The peptide was also effective against all four dengue virus serotypes. Thus, Yodha peptide could potentially be developed as a pan-therapeutic for Zika and dengue viruses.
format	article
author	Song Hee Lee Eui Ho Kim Justin T. O’neal Gordon Dale David J. Holthausen James R. Bowen Kendra M. Quicke Ioanna Skountzou Shyla Gopal Sanil George Jens Wrammert Mehul S. Suthar Joshy Jacob
author_facet	Song Hee Lee Eui Ho Kim Justin T. O’neal Gordon Dale David J. Holthausen James R. Bowen Kendra M. Quicke Ioanna Skountzou Shyla Gopal Sanil George Jens Wrammert Mehul S. Suthar Joshy Jacob
author_sort	Song Hee Lee
title	The amphibian peptide Yodha is virucidal for Zika and dengue viruses
title_short	The amphibian peptide Yodha is virucidal for Zika and dengue viruses
title_full	The amphibian peptide Yodha is virucidal for Zika and dengue viruses
title_fullStr	The amphibian peptide Yodha is virucidal for Zika and dengue viruses
title_full_unstemmed	The amphibian peptide Yodha is virucidal for Zika and dengue viruses
title_sort	amphibian peptide yodha is virucidal for zika and dengue viruses
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1222b054c19b4f9b953994df1b0439c9
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The amphibian peptide Yodha is virucidal for Zika and dengue viruses

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