Choroid plexus NKCC1 mediates cerebrospinal fluid clearance during mouse early postnatal development

Abnormal CSF accumulation in the brain can lead to hydrocephalus. The mechanisms regulating CSF clearance during early development are unclear. Here, the authors show that NKCC1 regulates the clearance of both CSF K+ and fluid volume through the choroid plexus during postnatal development in mice.

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Autores principales:	Huixin Xu, Ryann M. Fame, Cameron Sadegh, Jason Sutin, Christopher Naranjo, Della Syau, Jin Cui, Frederick B. Shipley, Amanda Vernon, Fan Gao, Yong Zhang, Michael J. Holtzman, Myriam Heiman, Benjamin C. Warf, Pei-Yi Lin, Maria K. Lehtinen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1226adb34adc4634871fcd9db63032d8
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spelling	oai:doaj.org-article:1226adb34adc4634871fcd9db63032d82021-12-02T13:56:46ZChoroid plexus NKCC1 mediates cerebrospinal fluid clearance during mouse early postnatal development10.1038/s41467-020-20666-32041-1723https://doaj.org/article/1226adb34adc4634871fcd9db63032d82021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20666-3https://doaj.org/toc/2041-1723Abnormal CSF accumulation in the brain can lead to hydrocephalus. The mechanisms regulating CSF clearance during early development are unclear. Here, the authors show that NKCC1 regulates the clearance of both CSF K+ and fluid volume through the choroid plexus during postnatal development in mice.Huixin XuRyann M. FameCameron SadeghJason SutinChristopher NaranjoDella SyauJin CuiFrederick B. ShipleyAmanda VernonFan GaoYong ZhangMichael J. HoltzmanMyriam HeimanBenjamin C. WarfPei-Yi LinMaria K. LehtinenNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Huixin Xu Ryann M. Fame Cameron Sadegh Jason Sutin Christopher Naranjo Della Syau Jin Cui Frederick B. Shipley Amanda Vernon Fan Gao Yong Zhang Michael J. Holtzman Myriam Heiman Benjamin C. Warf Pei-Yi Lin Maria K. Lehtinen Choroid plexus NKCC1 mediates cerebrospinal fluid clearance during mouse early postnatal development
description	Abnormal CSF accumulation in the brain can lead to hydrocephalus. The mechanisms regulating CSF clearance during early development are unclear. Here, the authors show that NKCC1 regulates the clearance of both CSF K+ and fluid volume through the choroid plexus during postnatal development in mice.
format	article
author	Huixin Xu Ryann M. Fame Cameron Sadegh Jason Sutin Christopher Naranjo Della Syau Jin Cui Frederick B. Shipley Amanda Vernon Fan Gao Yong Zhang Michael J. Holtzman Myriam Heiman Benjamin C. Warf Pei-Yi Lin Maria K. Lehtinen
author_facet	Huixin Xu Ryann M. Fame Cameron Sadegh Jason Sutin Christopher Naranjo Della Syau Jin Cui Frederick B. Shipley Amanda Vernon Fan Gao Yong Zhang Michael J. Holtzman Myriam Heiman Benjamin C. Warf Pei-Yi Lin Maria K. Lehtinen
author_sort	Huixin Xu
title	Choroid plexus NKCC1 mediates cerebrospinal fluid clearance during mouse early postnatal development
title_short	Choroid plexus NKCC1 mediates cerebrospinal fluid clearance during mouse early postnatal development
title_full	Choroid plexus NKCC1 mediates cerebrospinal fluid clearance during mouse early postnatal development
title_fullStr	Choroid plexus NKCC1 mediates cerebrospinal fluid clearance during mouse early postnatal development
title_full_unstemmed	Choroid plexus NKCC1 mediates cerebrospinal fluid clearance during mouse early postnatal development
title_sort	choroid plexus nkcc1 mediates cerebrospinal fluid clearance during mouse early postnatal development
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1226adb34adc4634871fcd9db63032d8
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Choroid plexus NKCC1 mediates cerebrospinal fluid clearance during mouse early postnatal development

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