Longitudinal proteomic profiling reveals increased early inflammation and sustained apoptosis proteins in severe COVID-19

Abstract SARS-CoV-2 infection has a risk to develop into life-threatening COVID-19 disease. Whereas age, hypertension, and chronic inflammatory conditions are risk factors, underlying host factors and markers for disease severity, e.g. requiring intensive care unit (ICU) treatment, remain poorly def...

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Autores principales:	Liis Haljasmägi, Ahto Salumets, Anna Pauliina Rumm, Meeri Jürgenson, Ekaterina Krassohhina, Anu Remm, Hanna Sein, Lauri Kareinen, Olli Vapalahti, Tarja Sironen, Hedi Peterson, Lili Milani, Anu Tamm, Adrian Hayday, Kai Kisand, Pärt Peterson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/122d14a3063c481cb0cc3d33b02d79ac
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spelling	oai:doaj.org-article:122d14a3063c481cb0cc3d33b02d79ac2021-12-02T15:09:57ZLongitudinal proteomic profiling reveals increased early inflammation and sustained apoptosis proteins in severe COVID-1910.1038/s41598-020-77525-w2045-2322https://doaj.org/article/122d14a3063c481cb0cc3d33b02d79ac2020-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-77525-whttps://doaj.org/toc/2045-2322Abstract SARS-CoV-2 infection has a risk to develop into life-threatening COVID-19 disease. Whereas age, hypertension, and chronic inflammatory conditions are risk factors, underlying host factors and markers for disease severity, e.g. requiring intensive care unit (ICU) treatment, remain poorly defined. To this end, we longitudinally profiled blood inflammation markers, antibodies, and 101 plasma proteins of hospitalized COVID-19 patients who did or did not require ICU admission. While essentially all patients displayed SARS-CoV-2-specific antibodies and virus-neutralization capacity within 12–15 days, a rapid, mostly transient upregulation of selective inflammatory markers including IL-6, CXCL10, CXCL11, IFNγ, IL-10, and monocyte-attracting CCL2, CCL7 and CCL8, was particularly evident in ICU patients. In addition, there was consistent and sustained upregulation of apoptosis-associated proteins CASP8, TNFSF14, HGF, and TGFB1, with HGF discriminating between ICU and non-ICU cohorts. Thus, COVID-19 is associated with a selective inflammatory milieu within which the apoptotic pathway is a cardinal feature with potential to aid risk-based patient stratification.Liis HaljasmägiAhto SalumetsAnna Pauliina RummMeeri JürgensonEkaterina KrassohhinaAnu RemmHanna SeinLauri KareinenOlli VapalahtiTarja SironenHedi PetersonLili MilaniAnu TammAdrian HaydayKai KisandPärt PetersonNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Liis Haljasmägi Ahto Salumets Anna Pauliina Rumm Meeri Jürgenson Ekaterina Krassohhina Anu Remm Hanna Sein Lauri Kareinen Olli Vapalahti Tarja Sironen Hedi Peterson Lili Milani Anu Tamm Adrian Hayday Kai Kisand Pärt Peterson Longitudinal proteomic profiling reveals increased early inflammation and sustained apoptosis proteins in severe COVID-19
description	Abstract SARS-CoV-2 infection has a risk to develop into life-threatening COVID-19 disease. Whereas age, hypertension, and chronic inflammatory conditions are risk factors, underlying host factors and markers for disease severity, e.g. requiring intensive care unit (ICU) treatment, remain poorly defined. To this end, we longitudinally profiled blood inflammation markers, antibodies, and 101 plasma proteins of hospitalized COVID-19 patients who did or did not require ICU admission. While essentially all patients displayed SARS-CoV-2-specific antibodies and virus-neutralization capacity within 12–15 days, a rapid, mostly transient upregulation of selective inflammatory markers including IL-6, CXCL10, CXCL11, IFNγ, IL-10, and monocyte-attracting CCL2, CCL7 and CCL8, was particularly evident in ICU patients. In addition, there was consistent and sustained upregulation of apoptosis-associated proteins CASP8, TNFSF14, HGF, and TGFB1, with HGF discriminating between ICU and non-ICU cohorts. Thus, COVID-19 is associated with a selective inflammatory milieu within which the apoptotic pathway is a cardinal feature with potential to aid risk-based patient stratification.
format	article
author	Liis Haljasmägi Ahto Salumets Anna Pauliina Rumm Meeri Jürgenson Ekaterina Krassohhina Anu Remm Hanna Sein Lauri Kareinen Olli Vapalahti Tarja Sironen Hedi Peterson Lili Milani Anu Tamm Adrian Hayday Kai Kisand Pärt Peterson
author_facet	Liis Haljasmägi Ahto Salumets Anna Pauliina Rumm Meeri Jürgenson Ekaterina Krassohhina Anu Remm Hanna Sein Lauri Kareinen Olli Vapalahti Tarja Sironen Hedi Peterson Lili Milani Anu Tamm Adrian Hayday Kai Kisand Pärt Peterson
author_sort	Liis Haljasmägi
title	Longitudinal proteomic profiling reveals increased early inflammation and sustained apoptosis proteins in severe COVID-19
title_short	Longitudinal proteomic profiling reveals increased early inflammation and sustained apoptosis proteins in severe COVID-19
title_full	Longitudinal proteomic profiling reveals increased early inflammation and sustained apoptosis proteins in severe COVID-19
title_fullStr	Longitudinal proteomic profiling reveals increased early inflammation and sustained apoptosis proteins in severe COVID-19
title_full_unstemmed	Longitudinal proteomic profiling reveals increased early inflammation and sustained apoptosis proteins in severe COVID-19
title_sort	longitudinal proteomic profiling reveals increased early inflammation and sustained apoptosis proteins in severe covid-19
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/122d14a3063c481cb0cc3d33b02d79ac
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Longitudinal proteomic profiling reveals increased early inflammation and sustained apoptosis proteins in severe COVID-19

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