MUC1-C regulates lineage plasticity driving progression to neuroendocrine prostate cancer

MUC1-C regulates lineage plasticity driving progression to neuroendocrine prostate cancer

MUC1-C is overexpressed in castration-resistant prostate cancer and neuroendocrine prostate cancer. Here, the authors show that MUC1-C drives lineage plasticity through MYC and BRN2, inducing neuroendocrine features and stemness in prostate cancer.

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Autores principales: Yota Yasumizu, Hasan Rajabi, Caining Jin, Tsuyoshi Hata, Sean Pitroda, Mark D. Long, Masayuki Hagiwara, Wei Li, Qiang Hu, Song Liu, Nami Yamashita, Atsushi Fushimi, Ling Kui, Mehmet Samur, Masaaki Yamamoto, Yan Zhang, Ning Zhang, Deli Hong, Takahiro Maeda, Takeo Kosaka, Kwok K. Wong, Mototsugu Oya, Donald Kufe
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/122d971bc14145f181528834a1ae353b
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spelling oai:doaj.org-article:122d971bc14145f181528834a1ae353b2021-12-02T14:40:29ZMUC1-C regulates lineage plasticity driving progression to neuroendocrine prostate cancer10.1038/s41467-019-14219-62041-1723https://doaj.org/article/122d971bc14145f181528834a1ae353b2020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-14219-6https://doaj.org/toc/2041-1723MUC1-C is overexpressed in castration-resistant prostate cancer and neuroendocrine prostate cancer. Here, the authors show that MUC1-C drives lineage plasticity through MYC and BRN2, inducing neuroendocrine features and stemness in prostate cancer.Yota YasumizuHasan RajabiCaining JinTsuyoshi HataSean PitrodaMark D. LongMasayuki HagiwaraWei LiQiang HuSong LiuNami YamashitaAtsushi FushimiLing KuiMehmet SamurMasaaki YamamotoYan ZhangNing ZhangDeli HongTakahiro MaedaTakeo KosakaKwok K. WongMototsugu OyaDonald KufeNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Yota Yasumizu
Hasan Rajabi
Caining Jin
Tsuyoshi Hata
Sean Pitroda
Mark D. Long
Masayuki Hagiwara
Wei Li
Qiang Hu
Song Liu
Nami Yamashita
Atsushi Fushimi
Ling Kui
Mehmet Samur
Masaaki Yamamoto
Yan Zhang
Ning Zhang
Deli Hong
Takahiro Maeda
Takeo Kosaka
Kwok K. Wong
Mototsugu Oya
Donald Kufe
MUC1-C regulates lineage plasticity driving progression to neuroendocrine prostate cancer
description MUC1-C is overexpressed in castration-resistant prostate cancer and neuroendocrine prostate cancer. Here, the authors show that MUC1-C drives lineage plasticity through MYC and BRN2, inducing neuroendocrine features and stemness in prostate cancer.
format article
author Yota Yasumizu
Hasan Rajabi
Caining Jin
Tsuyoshi Hata
Sean Pitroda
Mark D. Long
Masayuki Hagiwara
Wei Li
Qiang Hu
Song Liu
Nami Yamashita
Atsushi Fushimi
Ling Kui
Mehmet Samur
Masaaki Yamamoto
Yan Zhang
Ning Zhang
Deli Hong
Takahiro Maeda
Takeo Kosaka
Kwok K. Wong
Mototsugu Oya
Donald Kufe
author_facet Yota Yasumizu
Hasan Rajabi
Caining Jin
Tsuyoshi Hata
Sean Pitroda
Mark D. Long
Masayuki Hagiwara
Wei Li
Qiang Hu
Song Liu
Nami Yamashita
Atsushi Fushimi
Ling Kui
Mehmet Samur
Masaaki Yamamoto
Yan Zhang
Ning Zhang
Deli Hong
Takahiro Maeda
Takeo Kosaka
Kwok K. Wong
Mototsugu Oya
Donald Kufe
author_sort Yota Yasumizu
title MUC1-C regulates lineage plasticity driving progression to neuroendocrine prostate cancer
title_short MUC1-C regulates lineage plasticity driving progression to neuroendocrine prostate cancer
title_full MUC1-C regulates lineage plasticity driving progression to neuroendocrine prostate cancer
title_fullStr MUC1-C regulates lineage plasticity driving progression to neuroendocrine prostate cancer
title_full_unstemmed MUC1-C regulates lineage plasticity driving progression to neuroendocrine prostate cancer
title_sort muc1-c regulates lineage plasticity driving progression to neuroendocrine prostate cancer
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/122d971bc14145f181528834a1ae353b
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