Structural basis for inhibition of the AAA-ATPase Drg1 by diazaborine

The AAA-ATPase Drg1 is a key factor in eukaryotic ribosome biogenesis that initiates cytoplasmic maturation of the large subunit. Here the authors report the structure of Drg1 in complex with its specific inhibitor diazaborine and provide insight into the mechanism of inhibition and specificity of t...

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Autores principales:	Michael Prattes, Irina Grishkovskaya, Victor-Valentin Hodirnau, Ingrid Rössler, Isabella Klein, Christina Hetzmannseder, Gertrude Zisser, Christian C. Gruber, Karl Gruber, David Haselbach, Helmut Bergler
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/122ec46f55d14062aec5a3b3ed2f1dd3
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spelling	oai:doaj.org-article:122ec46f55d14062aec5a3b3ed2f1dd32021-12-02T17:34:39ZStructural basis for inhibition of the AAA-ATPase Drg1 by diazaborine10.1038/s41467-021-23854-x2041-1723https://doaj.org/article/122ec46f55d14062aec5a3b3ed2f1dd32021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23854-xhttps://doaj.org/toc/2041-1723The AAA-ATPase Drg1 is a key factor in eukaryotic ribosome biogenesis that initiates cytoplasmic maturation of the large subunit. Here the authors report the structure of Drg1 in complex with its specific inhibitor diazaborine and provide insight into the mechanism of inhibition and specificity of this class of inhibitors.Michael PrattesIrina GrishkovskayaVictor-Valentin HodirnauIngrid RösslerIsabella KleinChristina HetzmannsederGertrude ZisserChristian C. GruberKarl GruberDavid HaselbachHelmut BerglerNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Michael Prattes Irina Grishkovskaya Victor-Valentin Hodirnau Ingrid Rössler Isabella Klein Christina Hetzmannseder Gertrude Zisser Christian C. Gruber Karl Gruber David Haselbach Helmut Bergler Structural basis for inhibition of the AAA-ATPase Drg1 by diazaborine
description	The AAA-ATPase Drg1 is a key factor in eukaryotic ribosome biogenesis that initiates cytoplasmic maturation of the large subunit. Here the authors report the structure of Drg1 in complex with its specific inhibitor diazaborine and provide insight into the mechanism of inhibition and specificity of this class of inhibitors.
format	article
author	Michael Prattes Irina Grishkovskaya Victor-Valentin Hodirnau Ingrid Rössler Isabella Klein Christina Hetzmannseder Gertrude Zisser Christian C. Gruber Karl Gruber David Haselbach Helmut Bergler
author_facet	Michael Prattes Irina Grishkovskaya Victor-Valentin Hodirnau Ingrid Rössler Isabella Klein Christina Hetzmannseder Gertrude Zisser Christian C. Gruber Karl Gruber David Haselbach Helmut Bergler
author_sort	Michael Prattes
title	Structural basis for inhibition of the AAA-ATPase Drg1 by diazaborine
title_short	Structural basis for inhibition of the AAA-ATPase Drg1 by diazaborine
title_full	Structural basis for inhibition of the AAA-ATPase Drg1 by diazaborine
title_fullStr	Structural basis for inhibition of the AAA-ATPase Drg1 by diazaborine
title_full_unstemmed	Structural basis for inhibition of the AAA-ATPase Drg1 by diazaborine
title_sort	structural basis for inhibition of the aaa-atpase drg1 by diazaborine
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/122ec46f55d14062aec5a3b3ed2f1dd3
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Structural basis for inhibition of the AAA-ATPase Drg1 by diazaborine

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