Single-molecule sequencing detection of N6-methyladenine in microbial reference materials

N6-methyladenine is involved in many biological pathways for microbial survival and host interaction. Here the authors train a neural network for improved m6A detection in nanopore sequencing data and validate methylomes for a microbial reference community.

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Autores principales:	Alexa B. R. McIntyre, Noah Alexander, Kirill Grigorev, Daniela Bezdan, Heike Sichtig, Charles Y. Chiu, Christopher E. Mason
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1230778b6f7c4c39bf87c3285ae9672e
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spelling	oai:doaj.org-article:1230778b6f7c4c39bf87c3285ae9672e2021-12-02T17:01:47ZSingle-molecule sequencing detection of N6-methyladenine in microbial reference materials10.1038/s41467-019-08289-92041-1723https://doaj.org/article/1230778b6f7c4c39bf87c3285ae9672e2019-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08289-9https://doaj.org/toc/2041-1723N6-methyladenine is involved in many biological pathways for microbial survival and host interaction. Here the authors train a neural network for improved m6A detection in nanopore sequencing data and validate methylomes for a microbial reference community.Alexa B. R. McIntyreNoah AlexanderKirill GrigorevDaniela BezdanHeike SichtigCharles Y. ChiuChristopher E. MasonNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Alexa B. R. McIntyre Noah Alexander Kirill Grigorev Daniela Bezdan Heike Sichtig Charles Y. Chiu Christopher E. Mason Single-molecule sequencing detection of N6-methyladenine in microbial reference materials
description	N6-methyladenine is involved in many biological pathways for microbial survival and host interaction. Here the authors train a neural network for improved m6A detection in nanopore sequencing data and validate methylomes for a microbial reference community.
format	article
author	Alexa B. R. McIntyre Noah Alexander Kirill Grigorev Daniela Bezdan Heike Sichtig Charles Y. Chiu Christopher E. Mason
author_facet	Alexa B. R. McIntyre Noah Alexander Kirill Grigorev Daniela Bezdan Heike Sichtig Charles Y. Chiu Christopher E. Mason
author_sort	Alexa B. R. McIntyre
title	Single-molecule sequencing detection of N6-methyladenine in microbial reference materials
title_short	Single-molecule sequencing detection of N6-methyladenine in microbial reference materials
title_full	Single-molecule sequencing detection of N6-methyladenine in microbial reference materials
title_fullStr	Single-molecule sequencing detection of N6-methyladenine in microbial reference materials
title_full_unstemmed	Single-molecule sequencing detection of N6-methyladenine in microbial reference materials
title_sort	single-molecule sequencing detection of n6-methyladenine in microbial reference materials
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/1230778b6f7c4c39bf87c3285ae9672e
work_keys_str_mv	AT alexabrmcintyre singlemoleculesequencingdetectionofn6methyladenineinmicrobialreferencematerials AT noahalexander singlemoleculesequencingdetectionofn6methyladenineinmicrobialreferencematerials AT kirillgrigorev singlemoleculesequencingdetectionofn6methyladenineinmicrobialreferencematerials AT danielabezdan singlemoleculesequencingdetectionofn6methyladenineinmicrobialreferencematerials AT heikesichtig singlemoleculesequencingdetectionofn6methyladenineinmicrobialreferencematerials AT charlesychiu singlemoleculesequencingdetectionofn6methyladenineinmicrobialreferencematerials AT christopheremason singlemoleculesequencingdetectionofn6methyladenineinmicrobialreferencematerials
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Single-molecule sequencing detection of N6-methyladenine in microbial reference materials

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