The invasive pathogen Yersinia pestis disrupts host blood vasculature to spread and provoke hemorrhages.

Yersinia pestis is a powerful pathogen with a rare invasive capacity. After a flea bite, the plague bacillus can reach the bloodstream in a matter of days giving way to invade the whole organism reaching all organs and provoking disseminated hemorrhages. However, the mechanisms used by this bacteriu...

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Autores principales:	Guillain Mikaty, Héloïse Coullon, Laurence Fiette, Javier Pizarro-Cerdá, Elisabeth Carniel
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270
Acceso en línea:	https://doaj.org/article/123b85de85004b59a08967a8c6e7f4dc
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spelling	oai:doaj.org-article:123b85de85004b59a08967a8c6e7f4dc2021-11-25T06:31:44ZThe invasive pathogen Yersinia pestis disrupts host blood vasculature to spread and provoke hemorrhages.1935-27271935-273510.1371/journal.pntd.0009832https://doaj.org/article/123b85de85004b59a08967a8c6e7f4dc2021-10-01T00:00:00Zhttps://doi.org/10.1371/journal.pntd.0009832https://doaj.org/toc/1935-2727https://doaj.org/toc/1935-2735Yersinia pestis is a powerful pathogen with a rare invasive capacity. After a flea bite, the plague bacillus can reach the bloodstream in a matter of days giving way to invade the whole organism reaching all organs and provoking disseminated hemorrhages. However, the mechanisms used by this bacterium to cross and disrupt the endothelial vascular barrier remain poorly understood. In this study, an innovative model of in vivo infection was used to focus on the interaction between Y. pestis and its host vascular system. In the draining lymph nodes and in secondary organs, bacteria provoked the porosity and disruption of blood vessels. An in vitro model of endothelial barrier showed a role in this phenotype for the pYV/pCD1 plasmid that carries a Type Three Secretion System. This work supports that the pYV/pCD1 plasmid is responsible for the powerful tissue invasiveness capacity of the plague bacillus and the hemorrhagic features of plague.Guillain MikatyHéloïse CoullonLaurence FietteJavier Pizarro-CerdáElisabeth CarnielPublic Library of Science (PLoS)articleArctic medicine. Tropical medicineRC955-962Public aspects of medicineRA1-1270ENPLoS Neglected Tropical Diseases, Vol 15, Iss 10, p e0009832 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270
spellingShingle	Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Guillain Mikaty Héloïse Coullon Laurence Fiette Javier Pizarro-Cerdá Elisabeth Carniel The invasive pathogen Yersinia pestis disrupts host blood vasculature to spread and provoke hemorrhages.
description	Yersinia pestis is a powerful pathogen with a rare invasive capacity. After a flea bite, the plague bacillus can reach the bloodstream in a matter of days giving way to invade the whole organism reaching all organs and provoking disseminated hemorrhages. However, the mechanisms used by this bacterium to cross and disrupt the endothelial vascular barrier remain poorly understood. In this study, an innovative model of in vivo infection was used to focus on the interaction between Y. pestis and its host vascular system. In the draining lymph nodes and in secondary organs, bacteria provoked the porosity and disruption of blood vessels. An in vitro model of endothelial barrier showed a role in this phenotype for the pYV/pCD1 plasmid that carries a Type Three Secretion System. This work supports that the pYV/pCD1 plasmid is responsible for the powerful tissue invasiveness capacity of the plague bacillus and the hemorrhagic features of plague.
format	article
author	Guillain Mikaty Héloïse Coullon Laurence Fiette Javier Pizarro-Cerdá Elisabeth Carniel
author_facet	Guillain Mikaty Héloïse Coullon Laurence Fiette Javier Pizarro-Cerdá Elisabeth Carniel
author_sort	Guillain Mikaty
title	The invasive pathogen Yersinia pestis disrupts host blood vasculature to spread and provoke hemorrhages.
title_short	The invasive pathogen Yersinia pestis disrupts host blood vasculature to spread and provoke hemorrhages.
title_full	The invasive pathogen Yersinia pestis disrupts host blood vasculature to spread and provoke hemorrhages.
title_fullStr	The invasive pathogen Yersinia pestis disrupts host blood vasculature to spread and provoke hemorrhages.
title_full_unstemmed	The invasive pathogen Yersinia pestis disrupts host blood vasculature to spread and provoke hemorrhages.
title_sort	invasive pathogen yersinia pestis disrupts host blood vasculature to spread and provoke hemorrhages.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/123b85de85004b59a08967a8c6e7f4dc
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The invasive pathogen Yersinia pestis disrupts host blood vasculature to spread and provoke hemorrhages.

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