CYTOKINES GENETIC POLYMORPHISM: THE PAST AND THE FUTURE

The molecular genetics opens the new horizons in modern medicine, especially now when many diseases are given huge value in a type of their prevalence among various groups of population. Extremely high interleukin genes polymorphism degrees are studied well especially genetic polymorphism of tumor n...

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Autores principales:	L. V. Puzyryova, A. D. Safonov
Formato:	article
Lenguaje:	RU
Publicado:	Sankt-Peterburg : NIIÈM imeni Pastera 2016
Materias:	polymorphism of genes cytokine hiv infection anti-inflammatory cytokines pro-inflammatory cytokines tumor necrosis factor Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/123e579b74e048aca49b89064649a70a
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spelling	oai:doaj.org-article:123e579b74e048aca49b89064649a70a2021-11-22T07:09:47ZCYTOKINES GENETIC POLYMORPHISM: THE PAST AND THE FUTURE2220-76192313-739810.15789/2220-7619-2016-2-103-108https://doaj.org/article/123e579b74e048aca49b89064649a70a2016-06-01T00:00:00Zhttps://www.iimmun.ru/iimm/article/view/395https://doaj.org/toc/2220-7619https://doaj.org/toc/2313-7398The molecular genetics opens the new horizons in modern medicine, especially now when many diseases are given huge value in a type of their prevalence among various groups of population. Extremely high interleukin genes polymorphism degrees are studied well especially genetic polymorphism of tumor necrosis factor. Patients with HIV infection in the territory of Russia cause now the highest degree of mortality that is the most actual and socially significant problem of healthcare. This problems studying attracts many researchers. Works in respect of genetic immunity to a virus and influence of cytokines production on the disease forecast are especially interesting. One of the HIV replication influencing factors are cytokines, some of which, including the tumor necrosis factor and interleukin-6 can promote replication of HIV, raising an expression of virus regulatory genes. During disease progress in parallel of anti-inflammatory cytokines level increase (causing in this case rather ineffective antibodies level increase) there is an T-helpers suppression stimulating a strong cellular component. Cytokine network functioning during HIV infection depends on many reasons which the individual variation in cytokine production caused by a number of genetic features, as well as an existence of opportunistic infection. Cytokines polymorphism determination in HIV infected patients is necessary in clinical practice for disease progression forecast to adverse fast transition to AIDS that it is important to consider in a choice of tactics of the supporting therapy of HIV-positive patients. Considering insufficient efficiency of modern methods of treatment, restoration and modulation of cytokines balance will increase anti-virus activity of immune system, influencing the factors blocking replication of a HIV.L. V. PuzyryovaA. D. SafonovSankt-Peterburg : NIIÈM imeni Pasteraarticlepolymorphism of genescytokinehiv infectionanti-inflammatory cytokinespro-inflammatory cytokinestumor necrosis factorInfectious and parasitic diseasesRC109-216RUInfekciâ i Immunitet, Vol 6, Iss 2, Pp 103-108 (2016)
institution	DOAJ
collection	DOAJ
language	RU
topic	polymorphism of genes cytokine hiv infection anti-inflammatory cytokines pro-inflammatory cytokines tumor necrosis factor Infectious and parasitic diseases RC109-216
spellingShingle	polymorphism of genes cytokine hiv infection anti-inflammatory cytokines pro-inflammatory cytokines tumor necrosis factor Infectious and parasitic diseases RC109-216 L. V. Puzyryova A. D. Safonov CYTOKINES GENETIC POLYMORPHISM: THE PAST AND THE FUTURE
description	The molecular genetics opens the new horizons in modern medicine, especially now when many diseases are given huge value in a type of their prevalence among various groups of population. Extremely high interleukin genes polymorphism degrees are studied well especially genetic polymorphism of tumor necrosis factor. Patients with HIV infection in the territory of Russia cause now the highest degree of mortality that is the most actual and socially significant problem of healthcare. This problems studying attracts many researchers. Works in respect of genetic immunity to a virus and influence of cytokines production on the disease forecast are especially interesting. One of the HIV replication influencing factors are cytokines, some of which, including the tumor necrosis factor and interleukin-6 can promote replication of HIV, raising an expression of virus regulatory genes. During disease progress in parallel of anti-inflammatory cytokines level increase (causing in this case rather ineffective antibodies level increase) there is an T-helpers suppression stimulating a strong cellular component. Cytokine network functioning during HIV infection depends on many reasons which the individual variation in cytokine production caused by a number of genetic features, as well as an existence of opportunistic infection. Cytokines polymorphism determination in HIV infected patients is necessary in clinical practice for disease progression forecast to adverse fast transition to AIDS that it is important to consider in a choice of tactics of the supporting therapy of HIV-positive patients. Considering insufficient efficiency of modern methods of treatment, restoration and modulation of cytokines balance will increase anti-virus activity of immune system, influencing the factors blocking replication of a HIV.
format	article
author	L. V. Puzyryova A. D. Safonov
author_facet	L. V. Puzyryova A. D. Safonov
author_sort	L. V. Puzyryova
title	CYTOKINES GENETIC POLYMORPHISM: THE PAST AND THE FUTURE
title_short	CYTOKINES GENETIC POLYMORPHISM: THE PAST AND THE FUTURE
title_full	CYTOKINES GENETIC POLYMORPHISM: THE PAST AND THE FUTURE
title_fullStr	CYTOKINES GENETIC POLYMORPHISM: THE PAST AND THE FUTURE
title_full_unstemmed	CYTOKINES GENETIC POLYMORPHISM: THE PAST AND THE FUTURE
title_sort	cytokines genetic polymorphism: the past and the future
publisher	Sankt-Peterburg : NIIÈM imeni Pastera
publishDate	2016
url	https://doaj.org/article/123e579b74e048aca49b89064649a70a
work_keys_str_mv	AT lvpuzyryova cytokinesgeneticpolymorphismthepastandthefuture AT adsafonov cytokinesgeneticpolymorphismthepastandthefuture
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CYTOKINES GENETIC POLYMORPHISM: THE PAST AND THE FUTURE

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