Independent somatic evolution underlies clustered neuroendocrine tumors in the human small intestine

Small intestine neuroendocrine tumors (SI-NETs) are frequently multifocal and metastatic, but their tumourigenesis is still poorly understood. Here, the authors analyse multifocal SI-NET tumours with whole-genome sequencing, revealing the landscape of genomic alterations and frequent polyclonal orig...

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Autores principales:	Erik Elias, Arman Ardalan, Markus Lindberg, Susanne E. Reinsbach, Andreas Muth, Ola Nilsson, Yvonne Arvidsson, Erik Larsson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/123fb58011ff4c5299d20a2fa8383e2b
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spelling	oai:doaj.org-article:123fb58011ff4c5299d20a2fa8383e2b2021-11-08T11:05:29ZIndependent somatic evolution underlies clustered neuroendocrine tumors in the human small intestine10.1038/s41467-021-26581-52041-1723https://doaj.org/article/123fb58011ff4c5299d20a2fa8383e2b2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26581-5https://doaj.org/toc/2041-1723Small intestine neuroendocrine tumors (SI-NETs) are frequently multifocal and metastatic, but their tumourigenesis is still poorly understood. Here, the authors analyse multifocal SI-NET tumours with whole-genome sequencing, revealing the landscape of genomic alterations and frequent polyclonal origins.Erik EliasArman ArdalanMarkus LindbergSusanne E. ReinsbachAndreas MuthOla NilssonYvonne ArvidssonErik LarssonNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Erik Elias Arman Ardalan Markus Lindberg Susanne E. Reinsbach Andreas Muth Ola Nilsson Yvonne Arvidsson Erik Larsson Independent somatic evolution underlies clustered neuroendocrine tumors in the human small intestine
description	Small intestine neuroendocrine tumors (SI-NETs) are frequently multifocal and metastatic, but their tumourigenesis is still poorly understood. Here, the authors analyse multifocal SI-NET tumours with whole-genome sequencing, revealing the landscape of genomic alterations and frequent polyclonal origins.
format	article
author	Erik Elias Arman Ardalan Markus Lindberg Susanne E. Reinsbach Andreas Muth Ola Nilsson Yvonne Arvidsson Erik Larsson
author_facet	Erik Elias Arman Ardalan Markus Lindberg Susanne E. Reinsbach Andreas Muth Ola Nilsson Yvonne Arvidsson Erik Larsson
author_sort	Erik Elias
title	Independent somatic evolution underlies clustered neuroendocrine tumors in the human small intestine
title_short	Independent somatic evolution underlies clustered neuroendocrine tumors in the human small intestine
title_full	Independent somatic evolution underlies clustered neuroendocrine tumors in the human small intestine
title_fullStr	Independent somatic evolution underlies clustered neuroendocrine tumors in the human small intestine
title_full_unstemmed	Independent somatic evolution underlies clustered neuroendocrine tumors in the human small intestine
title_sort	independent somatic evolution underlies clustered neuroendocrine tumors in the human small intestine
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/123fb58011ff4c5299d20a2fa8383e2b
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Independent somatic evolution underlies clustered neuroendocrine tumors in the human small intestine

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