In Vitro Assembly and Stabilization of Dengue and Zika Virus Envelope Protein Homo-Dimers

In Vitro Assembly and Stabilization of Dengue and Zika Virus Envelope Protein Homo-Dimers

Abstract Zika virus (ZIKV) and the 4 dengue virus (DENV) serotypes are mosquito-borne Flaviviruses that are associated with severe neuronal and hemorrhagic syndromes. The mature flavivirus infectious virion has 90 envelope (E) protein homo-dimers that pack tightly to form a smooth protein coat with...

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Bibliographic Details
Main Authors: Stefan W. Metz, Emily N. Gallichotte, Alex Brackbill, Lakshmanane Premkumar, Michael J. Miley, Ralph Baric, Aravinda M. de Silva
Format: article
Language:EN
Published: Nature Portfolio 2017
Subjects:
Medicine
R
Science
Q
Online Access:https://doaj.org/article/124462baa03a44d88e19b793bcc298bf
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