Matrix metalloproteinases regulate the formation of dendritic spine head protrusions during chemically induced long-term potentiation.

Dendritic spines are are small membranous protrusions that extend from neuronal dendrites and harbor the majority of excitatory synapses. Increasing evidence has shown that matrix metalloproteinases (MMPs), a family of extracellularly acting and Zn(2+)-dependent endopeptidases, are able to rapidly m...

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Autores principales:	Zsuzsanna Szepesi, Monika Bijata, Blazej Ruszczycki, Leszek Kaczmarek, Jakub Wlodarczyk
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/124584fff00445a1ae018bddc5e4e3f3
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spelling	oai:doaj.org-article:124584fff00445a1ae018bddc5e4e3f32021-11-18T07:45:31ZMatrix metalloproteinases regulate the formation of dendritic spine head protrusions during chemically induced long-term potentiation.1932-620310.1371/journal.pone.0063314https://doaj.org/article/124584fff00445a1ae018bddc5e4e3f32013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23696812/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203Dendritic spines are are small membranous protrusions that extend from neuronal dendrites and harbor the majority of excitatory synapses. Increasing evidence has shown that matrix metalloproteinases (MMPs), a family of extracellularly acting and Zn(2+)-dependent endopeptidases, are able to rapidly modulate dendritic spine morphology. Spine head protrusions (SHPs) are filopodia-like processes that extend from the dendritic spine head, representing a form of postsynaptic structural remodeling in response to altered neuronal activity. Herein, we show that chemically induced long-term potentiation (cLTP) in dissociated hippocampal cultures upregulates MMP-9 activity that controls the formation of SHPs. Blocking of MMPs activity or microtubule dynamics abolishes the emergence of SHPs. In addition, autoactive recombinant MMP-9, promotes the formation of SHPs in organotypic hippocampal slices. Furthermore, spines with SHPs gained postsynaptic α-amino-3-hydroxyl-5-methyl-4-isoxazole propionic acid (AMPA) receptors upon cLTP and the synaptic delivery of AMPA receptors was controlled by MMPs. The present results strongly imply that MMP-9 is functionally involved in the formation of SHPs and the control of postsynaptic receptor distribution upon cLTP.Zsuzsanna SzepesiMonika BijataBlazej RuszczyckiLeszek KaczmarekJakub WlodarczykPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 5, p e63314 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Zsuzsanna Szepesi Monika Bijata Blazej Ruszczycki Leszek Kaczmarek Jakub Wlodarczyk Matrix metalloproteinases regulate the formation of dendritic spine head protrusions during chemically induced long-term potentiation.
description	Dendritic spines are are small membranous protrusions that extend from neuronal dendrites and harbor the majority of excitatory synapses. Increasing evidence has shown that matrix metalloproteinases (MMPs), a family of extracellularly acting and Zn(2+)-dependent endopeptidases, are able to rapidly modulate dendritic spine morphology. Spine head protrusions (SHPs) are filopodia-like processes that extend from the dendritic spine head, representing a form of postsynaptic structural remodeling in response to altered neuronal activity. Herein, we show that chemically induced long-term potentiation (cLTP) in dissociated hippocampal cultures upregulates MMP-9 activity that controls the formation of SHPs. Blocking of MMPs activity or microtubule dynamics abolishes the emergence of SHPs. In addition, autoactive recombinant MMP-9, promotes the formation of SHPs in organotypic hippocampal slices. Furthermore, spines with SHPs gained postsynaptic α-amino-3-hydroxyl-5-methyl-4-isoxazole propionic acid (AMPA) receptors upon cLTP and the synaptic delivery of AMPA receptors was controlled by MMPs. The present results strongly imply that MMP-9 is functionally involved in the formation of SHPs and the control of postsynaptic receptor distribution upon cLTP.
format	article
author	Zsuzsanna Szepesi Monika Bijata Blazej Ruszczycki Leszek Kaczmarek Jakub Wlodarczyk
author_facet	Zsuzsanna Szepesi Monika Bijata Blazej Ruszczycki Leszek Kaczmarek Jakub Wlodarczyk
author_sort	Zsuzsanna Szepesi
title	Matrix metalloproteinases regulate the formation of dendritic spine head protrusions during chemically induced long-term potentiation.
title_short	Matrix metalloproteinases regulate the formation of dendritic spine head protrusions during chemically induced long-term potentiation.
title_full	Matrix metalloproteinases regulate the formation of dendritic spine head protrusions during chemically induced long-term potentiation.
title_fullStr	Matrix metalloproteinases regulate the formation of dendritic spine head protrusions during chemically induced long-term potentiation.
title_full_unstemmed	Matrix metalloproteinases regulate the formation of dendritic spine head protrusions during chemically induced long-term potentiation.
title_sort	matrix metalloproteinases regulate the formation of dendritic spine head protrusions during chemically induced long-term potentiation.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/124584fff00445a1ae018bddc5e4e3f3
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Matrix metalloproteinases regulate the formation of dendritic spine head protrusions during chemically induced long-term potentiation.

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