Exploring the role of immune pathways in the risk and development of depression in adolescence: Research protocol of the IDEA-FLAME study

Extensive research suggests a role for the innate immune system in the pathogenesis of depression, but most of the studies are conducted in adult populations, in high-income countries and mainly focus on the study of inflammatory proteins alone, which provides only a limited understanding of the imm...

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Autores principales:	Valeria Mondelli, Annamaria Cattaneo, Naghmeh Nikkheslat, Laila Souza, Annabel Walsh, Zuzanna Zajkowska, Valentina Zonca, Moira Marizzoni, Helen L. Fisher, Brandon A. Kohrt, Christian Kieling, Paola Di Meglio
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Depression Adolescence Cytokines RNAseq Flow cytometry Immune cells Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/1246efb25ee045a0ac736a77cb7ea1f0
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spelling	oai:doaj.org-article:1246efb25ee045a0ac736a77cb7ea1f02021-12-04T04:36:00ZExploring the role of immune pathways in the risk and development of depression in adolescence: Research protocol of the IDEA-FLAME study2666-354610.1016/j.bbih.2021.100396https://doaj.org/article/1246efb25ee045a0ac736a77cb7ea1f02021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S266635462100199Xhttps://doaj.org/toc/2666-3546Extensive research suggests a role for the innate immune system in the pathogenesis of depression, but most of the studies are conducted in adult populations, in high-income countries and mainly focus on the study of inflammatory proteins alone, which provides only a limited understanding of the immune pathways involved in the development of depression. The IDEA-FLAME study aims to identify immune phenotypes underlying increased risk of developing depression in adolescence in a middle-income country. To this end, we will perform deep-immunophenotyping of peripheral blood mononuclear cells and RNA genome-wide gene expression analyses in a longitudinal cohort of Brazilian adolescents stratified for depression risk. The project will involve the 3-year follow-up of an already recruited cohort of 150 Brazilian adolescents selected for risk/presence of depression on the basis of a composite risk score we developed using sociodemographic characteristics (50 adolescents with low-risk and 50 with high-risk of developing depression, and 50 adolescents with a current major depressive disorder). We will 1) test whether the risk group classification at baseline is associated with differences in immune cell frequency, phenotype and functional status, 2) test whether baseline immune markers (cytokines and immune cell markers) are associated with severity of depression at 3-year follow-up, and 3) identify changes in gene expression of immune pathways over the 3-year follow-up in adolescents with increased risk and presence of depression. Because of the exploratory nature of the study, the findings would need to be replicated in a separate and larger sample. Ultimately, this research will contribute to elucidating key immune therapeutic targets and inform the development of interventions to prevent onset of depression among adolescents.Valeria MondelliAnnamaria CattaneoNaghmeh NikkheslatLaila SouzaAnnabel WalshZuzanna ZajkowskaValentina ZoncaMoira MarizzoniHelen L. FisherBrandon A. KohrtChristian KielingPaola Di MeglioElsevierarticleDepressionAdolescenceCytokinesRNAseqFlow cytometryImmune cellsNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENBrain, Behavior, & Immunity - Health, Vol 18, Iss , Pp 100396- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Depression Adolescence Cytokines RNAseq Flow cytometry Immune cells Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	Depression Adolescence Cytokines RNAseq Flow cytometry Immune cells Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Valeria Mondelli Annamaria Cattaneo Naghmeh Nikkheslat Laila Souza Annabel Walsh Zuzanna Zajkowska Valentina Zonca Moira Marizzoni Helen L. Fisher Brandon A. Kohrt Christian Kieling Paola Di Meglio Exploring the role of immune pathways in the risk and development of depression in adolescence: Research protocol of the IDEA-FLAME study
description	Extensive research suggests a role for the innate immune system in the pathogenesis of depression, but most of the studies are conducted in adult populations, in high-income countries and mainly focus on the study of inflammatory proteins alone, which provides only a limited understanding of the immune pathways involved in the development of depression. The IDEA-FLAME study aims to identify immune phenotypes underlying increased risk of developing depression in adolescence in a middle-income country. To this end, we will perform deep-immunophenotyping of peripheral blood mononuclear cells and RNA genome-wide gene expression analyses in a longitudinal cohort of Brazilian adolescents stratified for depression risk. The project will involve the 3-year follow-up of an already recruited cohort of 150 Brazilian adolescents selected for risk/presence of depression on the basis of a composite risk score we developed using sociodemographic characteristics (50 adolescents with low-risk and 50 with high-risk of developing depression, and 50 adolescents with a current major depressive disorder). We will 1) test whether the risk group classification at baseline is associated with differences in immune cell frequency, phenotype and functional status, 2) test whether baseline immune markers (cytokines and immune cell markers) are associated with severity of depression at 3-year follow-up, and 3) identify changes in gene expression of immune pathways over the 3-year follow-up in adolescents with increased risk and presence of depression. Because of the exploratory nature of the study, the findings would need to be replicated in a separate and larger sample. Ultimately, this research will contribute to elucidating key immune therapeutic targets and inform the development of interventions to prevent onset of depression among adolescents.
format	article
author	Valeria Mondelli Annamaria Cattaneo Naghmeh Nikkheslat Laila Souza Annabel Walsh Zuzanna Zajkowska Valentina Zonca Moira Marizzoni Helen L. Fisher Brandon A. Kohrt Christian Kieling Paola Di Meglio
author_facet	Valeria Mondelli Annamaria Cattaneo Naghmeh Nikkheslat Laila Souza Annabel Walsh Zuzanna Zajkowska Valentina Zonca Moira Marizzoni Helen L. Fisher Brandon A. Kohrt Christian Kieling Paola Di Meglio
author_sort	Valeria Mondelli
title	Exploring the role of immune pathways in the risk and development of depression in adolescence: Research protocol of the IDEA-FLAME study
title_short	Exploring the role of immune pathways in the risk and development of depression in adolescence: Research protocol of the IDEA-FLAME study
title_full	Exploring the role of immune pathways in the risk and development of depression in adolescence: Research protocol of the IDEA-FLAME study
title_fullStr	Exploring the role of immune pathways in the risk and development of depression in adolescence: Research protocol of the IDEA-FLAME study
title_full_unstemmed	Exploring the role of immune pathways in the risk and development of depression in adolescence: Research protocol of the IDEA-FLAME study
title_sort	exploring the role of immune pathways in the risk and development of depression in adolescence: research protocol of the idea-flame study
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/1246efb25ee045a0ac736a77cb7ea1f0
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Exploring the role of immune pathways in the risk and development of depression in adolescence: Research protocol of the IDEA-FLAME study

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