Ventromedial medulla inhibitory neuron inactivation induces REM sleep without atonia and REM sleep behavior disorder

Ventromedial medulla inhibitory neuron inactivation induces REM sleep without atonia and REM sleep behavior disorder

Loss of muscle tone is a distinguishing feature of paradoxical or REM sleep (PS) and is disrupted in REM sleep behavior disorder. Here the authors report that GABA/glycine inhibitory neurons in the ventromedial medulla are essential for producing PS muscle atonia without affecting PS quantity.

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Autores principales: Sara Valencia Garcia, Frédéric Brischoux, Olivier Clément, Paul-Antoine Libourel, Sébastien Arthaud, Michael Lazarus, Pierre-Hervé Luppi, Patrice Fort
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/124c4eb15dea4030a49569b5688a42e4
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spelling oai:doaj.org-article:124c4eb15dea4030a49569b5688a42e42021-12-02T16:56:56ZVentromedial medulla inhibitory neuron inactivation induces REM sleep without atonia and REM sleep behavior disorder10.1038/s41467-017-02761-02041-1723https://doaj.org/article/124c4eb15dea4030a49569b5688a42e42018-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02761-0https://doaj.org/toc/2041-1723Loss of muscle tone is a distinguishing feature of paradoxical or REM sleep (PS) and is disrupted in REM sleep behavior disorder. Here the authors report that GABA/glycine inhibitory neurons in the ventromedial medulla are essential for producing PS muscle atonia without affecting PS quantity.Sara Valencia GarciaFrédéric BrischouxOlivier ClémentPaul-Antoine LibourelSébastien ArthaudMichael LazarusPierre-Hervé LuppiPatrice FortNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Sara Valencia Garcia
Frédéric Brischoux
Olivier Clément
Paul-Antoine Libourel
Sébastien Arthaud
Michael Lazarus
Pierre-Hervé Luppi
Patrice Fort
Ventromedial medulla inhibitory neuron inactivation induces REM sleep without atonia and REM sleep behavior disorder
description Loss of muscle tone is a distinguishing feature of paradoxical or REM sleep (PS) and is disrupted in REM sleep behavior disorder. Here the authors report that GABA/glycine inhibitory neurons in the ventromedial medulla are essential for producing PS muscle atonia without affecting PS quantity.
format article
author Sara Valencia Garcia
Frédéric Brischoux
Olivier Clément
Paul-Antoine Libourel
Sébastien Arthaud
Michael Lazarus
Pierre-Hervé Luppi
Patrice Fort
author_facet Sara Valencia Garcia
Frédéric Brischoux
Olivier Clément
Paul-Antoine Libourel
Sébastien Arthaud
Michael Lazarus
Pierre-Hervé Luppi
Patrice Fort
author_sort Sara Valencia Garcia
title Ventromedial medulla inhibitory neuron inactivation induces REM sleep without atonia and REM sleep behavior disorder
title_short Ventromedial medulla inhibitory neuron inactivation induces REM sleep without atonia and REM sleep behavior disorder
title_full Ventromedial medulla inhibitory neuron inactivation induces REM sleep without atonia and REM sleep behavior disorder
title_fullStr Ventromedial medulla inhibitory neuron inactivation induces REM sleep without atonia and REM sleep behavior disorder
title_full_unstemmed Ventromedial medulla inhibitory neuron inactivation induces REM sleep without atonia and REM sleep behavior disorder
title_sort ventromedial medulla inhibitory neuron inactivation induces rem sleep without atonia and rem sleep behavior disorder
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/124c4eb15dea4030a49569b5688a42e4
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