FUT8-mediated aberrant N-glycosylation of B7H3 suppresses the immune response in triple-negative breast cancer
B7H3 is a transmembrane B7 family checkpoint molecule present on many cancer cells. Here the authors show that FUT8 mediates fucosylation of B7H3 to limit the immune response to triple-negative breast cancer as a potentially targeted mechanism of non-responsiveness to current checkpoint therapies.
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Nature Portfolio
2021
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| Acceso en línea: | https://doaj.org/article/1258b476d9c94dcb951013c2b2aa4bd4 |
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oai:doaj.org-article:1258b476d9c94dcb951013c2b2aa4bd42021-12-02T14:35:46ZFUT8-mediated aberrant N-glycosylation of B7H3 suppresses the immune response in triple-negative breast cancer10.1038/s41467-021-22618-x2041-1723https://doaj.org/article/1258b476d9c94dcb951013c2b2aa4bd42021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22618-xhttps://doaj.org/toc/2041-1723B7H3 is a transmembrane B7 family checkpoint molecule present on many cancer cells. Here the authors show that FUT8 mediates fucosylation of B7H3 to limit the immune response to triple-negative breast cancer as a potentially targeted mechanism of non-responsiveness to current checkpoint therapies.Yun HuangHai-Liang ZhangZhi-Ling LiTian DuYu-Hong ChenYan WangHuan-He NiKai-Ming ZhangJia MaiBing-Xin HuJun-Hao HuangLi-Huan ZhouDong YangXiao-Dan PengGong-Kan FengJun TangXiao-Feng ZhuRong DengNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-18 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Yun Huang Hai-Liang Zhang Zhi-Ling Li Tian Du Yu-Hong Chen Yan Wang Huan-He Ni Kai-Ming Zhang Jia Mai Bing-Xin Hu Jun-Hao Huang Li-Huan Zhou Dong Yang Xiao-Dan Peng Gong-Kan Feng Jun Tang Xiao-Feng Zhu Rong Deng FUT8-mediated aberrant N-glycosylation of B7H3 suppresses the immune response in triple-negative breast cancer |
| description |
B7H3 is a transmembrane B7 family checkpoint molecule present on many cancer cells. Here the authors show that FUT8 mediates fucosylation of B7H3 to limit the immune response to triple-negative breast cancer as a potentially targeted mechanism of non-responsiveness to current checkpoint therapies. |
| format |
article |
| author |
Yun Huang Hai-Liang Zhang Zhi-Ling Li Tian Du Yu-Hong Chen Yan Wang Huan-He Ni Kai-Ming Zhang Jia Mai Bing-Xin Hu Jun-Hao Huang Li-Huan Zhou Dong Yang Xiao-Dan Peng Gong-Kan Feng Jun Tang Xiao-Feng Zhu Rong Deng |
| author_facet |
Yun Huang Hai-Liang Zhang Zhi-Ling Li Tian Du Yu-Hong Chen Yan Wang Huan-He Ni Kai-Ming Zhang Jia Mai Bing-Xin Hu Jun-Hao Huang Li-Huan Zhou Dong Yang Xiao-Dan Peng Gong-Kan Feng Jun Tang Xiao-Feng Zhu Rong Deng |
| author_sort |
Yun Huang |
| title |
FUT8-mediated aberrant N-glycosylation of B7H3 suppresses the immune response in triple-negative breast cancer |
| title_short |
FUT8-mediated aberrant N-glycosylation of B7H3 suppresses the immune response in triple-negative breast cancer |
| title_full |
FUT8-mediated aberrant N-glycosylation of B7H3 suppresses the immune response in triple-negative breast cancer |
| title_fullStr |
FUT8-mediated aberrant N-glycosylation of B7H3 suppresses the immune response in triple-negative breast cancer |
| title_full_unstemmed |
FUT8-mediated aberrant N-glycosylation of B7H3 suppresses the immune response in triple-negative breast cancer |
| title_sort |
fut8-mediated aberrant n-glycosylation of b7h3 suppresses the immune response in triple-negative breast cancer |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/1258b476d9c94dcb951013c2b2aa4bd4 |
| work_keys_str_mv |
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| _version_ |
1718391055437529088 |