Large cell morphology, CMYC+ tumour cells, and PD-1+ tumour cell/intense PD-L1+ cell reactions are important prognostic factors in nodal peripheral T-cell lymphomas with T follicular helper markers

Abstract Background The clinicopathological characteristics and prognostic factors in nodal peripheral T-cell lymphomas (PTCLs) with two or more T follicular helper markers (TFH+) are not adequately investigated. Methods Immunohistologically, we selected 22 patients with TFH+ lymphoma (PTCL-TFH) in...

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Autores principales:	Yasuhito Mihashi, Shoichi Kimura, Hiromi Iwasaki, Yumi Oshiro, Yasushi Takamatsu, Shigeto Kawauchi, Shohei Shimajiri, Kenji Ishizuka, Morishige Takeshita
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	AITL CMYC PD-1 PD-L1 Peripheral T-cell lymphoma T follicular helper cell Pathology RB1-214
Acceso en línea:	https://doaj.org/article/125b8136aa08439e9210053c714ac3ac
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spelling	oai:doaj.org-article:125b8136aa08439e9210053c714ac3ac2021-11-08T11:13:46ZLarge cell morphology, CMYC+ tumour cells, and PD-1+ tumour cell/intense PD-L1+ cell reactions are important prognostic factors in nodal peripheral T-cell lymphomas with T follicular helper markers10.1186/s13000-021-01163-71746-1596https://doaj.org/article/125b8136aa08439e9210053c714ac3ac2021-11-01T00:00:00Zhttps://doi.org/10.1186/s13000-021-01163-7https://doaj.org/toc/1746-1596Abstract Background The clinicopathological characteristics and prognostic factors in nodal peripheral T-cell lymphomas (PTCLs) with two or more T follicular helper markers (TFH+) are not adequately investigated. Methods Immunohistologically, we selected 22 patients with TFH+ lymphoma (PTCL-TFH) in 47 of PTCL-not otherwise specified (NOS), and subclassified into large and small cell groups. We compared the two groups with 39 angioimmunoblastic T-cell lymphoma (AITL) and seven follicular T-cell lymphoma (F-TCL) patients. Prognostic factors were analysed by overall survival in patients with three types of TFH+ PTCLs. Results Thirteen large cell and nine small cell PTCL-TFH patients had more than two TFH markers including programmed cell death-1 (PD-1). Large cell PTCL-TFH showed frequent CMYC expression in 10 patients (77%), and four of 11 large cell group (36%) had somatic RHOA G17V gene mutation by Sanger sequencing. Large cell PTCL-TFH patients showed significantly worse prognosis than those of the small cell group, AITL, and F-TCL (p < 0.05). In TFH+ PTCLs, CMYC+ tumour cells, and combined PD-1 ligand 1 (PD-L1) + tumour cells and intense reaction of PD-L1+ non-neoplastic cells (high PD-L1+ cell group) were significantly poor prognostic factors (p < 0.05). Combinations of CMYC+ or PD-1+ tumour cells and high PD-L1+ cell group indicated significantly poor prognosis (p < 0.01). Conclusion Large cell PTCL-TFH indicated poor prognosis in TFH+ PTCLs. These data suggested that CMYC+ tumour cells and intense PD-L1+ cell reaction influenced tumour cell progression in TFH+ PTCLs, and PD-1+ tumour cell/intense PD-L1+ cell reactions may play a role in immune evasion.Yasuhito MihashiShoichi KimuraHiromi IwasakiYumi OshiroYasushi TakamatsuShigeto KawauchiShohei ShimajiriKenji IshizukaMorishige TakeshitaBMCarticleAITLCMYCPD-1PD-L1Peripheral T-cell lymphomaT follicular helper cellPathologyRB1-214ENDiagnostic Pathology, Vol 16, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	AITL CMYC PD-1 PD-L1 Peripheral T-cell lymphoma T follicular helper cell Pathology RB1-214
spellingShingle	AITL CMYC PD-1 PD-L1 Peripheral T-cell lymphoma T follicular helper cell Pathology RB1-214 Yasuhito Mihashi Shoichi Kimura Hiromi Iwasaki Yumi Oshiro Yasushi Takamatsu Shigeto Kawauchi Shohei Shimajiri Kenji Ishizuka Morishige Takeshita Large cell morphology, CMYC+ tumour cells, and PD-1+ tumour cell/intense PD-L1+ cell reactions are important prognostic factors in nodal peripheral T-cell lymphomas with T follicular helper markers
description	Abstract Background The clinicopathological characteristics and prognostic factors in nodal peripheral T-cell lymphomas (PTCLs) with two or more T follicular helper markers (TFH+) are not adequately investigated. Methods Immunohistologically, we selected 22 patients with TFH+ lymphoma (PTCL-TFH) in 47 of PTCL-not otherwise specified (NOS), and subclassified into large and small cell groups. We compared the two groups with 39 angioimmunoblastic T-cell lymphoma (AITL) and seven follicular T-cell lymphoma (F-TCL) patients. Prognostic factors were analysed by overall survival in patients with three types of TFH+ PTCLs. Results Thirteen large cell and nine small cell PTCL-TFH patients had more than two TFH markers including programmed cell death-1 (PD-1). Large cell PTCL-TFH showed frequent CMYC expression in 10 patients (77%), and four of 11 large cell group (36%) had somatic RHOA G17V gene mutation by Sanger sequencing. Large cell PTCL-TFH patients showed significantly worse prognosis than those of the small cell group, AITL, and F-TCL (p < 0.05). In TFH+ PTCLs, CMYC+ tumour cells, and combined PD-1 ligand 1 (PD-L1) + tumour cells and intense reaction of PD-L1+ non-neoplastic cells (high PD-L1+ cell group) were significantly poor prognostic factors (p < 0.05). Combinations of CMYC+ or PD-1+ tumour cells and high PD-L1+ cell group indicated significantly poor prognosis (p < 0.01). Conclusion Large cell PTCL-TFH indicated poor prognosis in TFH+ PTCLs. These data suggested that CMYC+ tumour cells and intense PD-L1+ cell reaction influenced tumour cell progression in TFH+ PTCLs, and PD-1+ tumour cell/intense PD-L1+ cell reactions may play a role in immune evasion.
format	article
author	Yasuhito Mihashi Shoichi Kimura Hiromi Iwasaki Yumi Oshiro Yasushi Takamatsu Shigeto Kawauchi Shohei Shimajiri Kenji Ishizuka Morishige Takeshita
author_facet	Yasuhito Mihashi Shoichi Kimura Hiromi Iwasaki Yumi Oshiro Yasushi Takamatsu Shigeto Kawauchi Shohei Shimajiri Kenji Ishizuka Morishige Takeshita
author_sort	Yasuhito Mihashi
title	Large cell morphology, CMYC+ tumour cells, and PD-1+ tumour cell/intense PD-L1+ cell reactions are important prognostic factors in nodal peripheral T-cell lymphomas with T follicular helper markers
title_short	Large cell morphology, CMYC+ tumour cells, and PD-1+ tumour cell/intense PD-L1+ cell reactions are important prognostic factors in nodal peripheral T-cell lymphomas with T follicular helper markers
title_full	Large cell morphology, CMYC+ tumour cells, and PD-1+ tumour cell/intense PD-L1+ cell reactions are important prognostic factors in nodal peripheral T-cell lymphomas with T follicular helper markers
title_fullStr	Large cell morphology, CMYC+ tumour cells, and PD-1+ tumour cell/intense PD-L1+ cell reactions are important prognostic factors in nodal peripheral T-cell lymphomas with T follicular helper markers
title_full_unstemmed	Large cell morphology, CMYC+ tumour cells, and PD-1+ tumour cell/intense PD-L1+ cell reactions are important prognostic factors in nodal peripheral T-cell lymphomas with T follicular helper markers
title_sort	large cell morphology, cmyc+ tumour cells, and pd-1+ tumour cell/intense pd-l1+ cell reactions are important prognostic factors in nodal peripheral t-cell lymphomas with t follicular helper markers
publisher	BMC
publishDate	2021
url	https://doaj.org/article/125b8136aa08439e9210053c714ac3ac
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Large cell morphology, CMYC+ tumour cells, and PD-1+ tumour cell/intense PD-L1+ cell reactions are important prognostic factors in nodal peripheral T-cell lymphomas with T follicular helper markers

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