Cognitive deficits are associated with frontal and temporal lobe white matter lesions in middle-aged adults living in the community.

<h4>Background</h4>The association between brain white matter lesions and cognitive impairment in old age is well established. However, little is known about this association in midlife. As this information will inform policy for early preventative healthcare initiatives, we investigated...

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Autores principales:	David Bunce, Kaarin J Anstey, Nicolas Cherbuin, Richard Burns, Helen Christensen, Wei Wen, Perminder S Sachdev
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2010
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/126153398116495dbbfc406a923964b8
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spelling	oai:doaj.org-article:126153398116495dbbfc406a923964b82021-11-18T07:03:00ZCognitive deficits are associated with frontal and temporal lobe white matter lesions in middle-aged adults living in the community.1932-620310.1371/journal.pone.0013567https://doaj.org/article/126153398116495dbbfc406a923964b82010-10-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21042415/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>The association between brain white matter lesions and cognitive impairment in old age is well established. However, little is known about this association in midlife. As this information will inform policy for early preventative healthcare initiatives, we investigated non-periventricular frontal, temporal, parietal and occipital lobe white matter hyperintensities (WMH) in relation to cognitive function in 428 (232 women) community-dwelling adults aged 44 to 48 years.<h4>Results</h4>Frontal white matter lesions were significantly associated with greater intraindividual RT variability in women, while temporal WMH were associated with face recognition deficits in men. Parietal and occipital lobe lesions were unrelated to cognitive performance. These findings did not differ when education and a range of health variables, including vascular risk factors, were taken into account.<h4>Conclusion</h4>Gender differences in WMH-cognition associations are discussed, and we conclude that small vessel disease is present in midlife and has functional consequences which are generally not recognized. Preventative strategies should, therefore, begin early in life.David BunceKaarin J AnsteyNicolas CherbuinRichard BurnsHelen ChristensenWei WenPerminder S SachdevPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 5, Iss 10, p e13567 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q David Bunce Kaarin J Anstey Nicolas Cherbuin Richard Burns Helen Christensen Wei Wen Perminder S Sachdev Cognitive deficits are associated with frontal and temporal lobe white matter lesions in middle-aged adults living in the community.
description	<h4>Background</h4>The association between brain white matter lesions and cognitive impairment in old age is well established. However, little is known about this association in midlife. As this information will inform policy for early preventative healthcare initiatives, we investigated non-periventricular frontal, temporal, parietal and occipital lobe white matter hyperintensities (WMH) in relation to cognitive function in 428 (232 women) community-dwelling adults aged 44 to 48 years.<h4>Results</h4>Frontal white matter lesions were significantly associated with greater intraindividual RT variability in women, while temporal WMH were associated with face recognition deficits in men. Parietal and occipital lobe lesions were unrelated to cognitive performance. These findings did not differ when education and a range of health variables, including vascular risk factors, were taken into account.<h4>Conclusion</h4>Gender differences in WMH-cognition associations are discussed, and we conclude that small vessel disease is present in midlife and has functional consequences which are generally not recognized. Preventative strategies should, therefore, begin early in life.
format	article
author	David Bunce Kaarin J Anstey Nicolas Cherbuin Richard Burns Helen Christensen Wei Wen Perminder S Sachdev
author_facet	David Bunce Kaarin J Anstey Nicolas Cherbuin Richard Burns Helen Christensen Wei Wen Perminder S Sachdev
author_sort	David Bunce
title	Cognitive deficits are associated with frontal and temporal lobe white matter lesions in middle-aged adults living in the community.
title_short	Cognitive deficits are associated with frontal and temporal lobe white matter lesions in middle-aged adults living in the community.
title_full	Cognitive deficits are associated with frontal and temporal lobe white matter lesions in middle-aged adults living in the community.
title_fullStr	Cognitive deficits are associated with frontal and temporal lobe white matter lesions in middle-aged adults living in the community.
title_full_unstemmed	Cognitive deficits are associated with frontal and temporal lobe white matter lesions in middle-aged adults living in the community.
title_sort	cognitive deficits are associated with frontal and temporal lobe white matter lesions in middle-aged adults living in the community.
publisher	Public Library of Science (PLoS)
publishDate	2010
url	https://doaj.org/article/126153398116495dbbfc406a923964b8
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Cognitive deficits are associated with frontal and temporal lobe white matter lesions in middle-aged adults living in the community.

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