Everolimus: the first approved product for patients with advanced renal cell cancer after sunitinib and/or sorafenib

Chris CoppinMedical Oncology, BC Cancer Agency and University of British Columbia, Vancouver, CanadaAbstract: Everolimus (RAD001, Afinitor® Novartis) is the first oral inhibitor of mTOR (mammalian target of rapamycin) to reach the oncology clinic. Everolimus 10 mg daily achieves complete...

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Autor principal: Chris Coppin
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Publicado: Dove Medical Press 2010
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Acceso en línea:https://doaj.org/article/126440ea33894236b7530b0995a5c6eb
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spelling oai:doaj.org-article:126440ea33894236b7530b0995a5c6eb2021-12-02T09:47:05ZEverolimus: the first approved product for patients with advanced renal cell cancer after sunitinib and/or sorafenib1177-54751177-5491https://doaj.org/article/126440ea33894236b7530b0995a5c6eb2010-04-01T00:00:00Zhttp://www.dovepress.com/everolimus-the-first-approved-product-for-patients-with-advanced-renal-a4336https://doaj.org/toc/1177-5475https://doaj.org/toc/1177-5491Chris CoppinMedical Oncology, BC Cancer Agency and University of British Columbia, Vancouver, CanadaAbstract: Everolimus (RAD001, Afinitor® Novartis) is the first oral inhibitor of mTOR (mammalian target of rapamycin) to reach the oncology clinic. Everolimus 10 mg daily achieves complete inhibition of its target at below the maximum tolerable dose for most patients. A phase III randomized placebo-controlled trial has examined the impact of everolimus in patients with clear cell renal cancers and progressive disease on or within 6 months of the VEGFR tyrosine kinase inhibitors sunitinib and/or sorafenib. The primary endpoint of progression-free survival was increased from median 1.9 to 4.9 months (hazard ratio 0.33, P < 0.001) and 25% were still progression-free after 10 months of everolimus therapy. There was a delay in time to decline of performance status and trends to improvement in quality of life, disease-related symptoms, and overall survival despite crossover of the majority of patients assigned to placebo. In 2009, everolimus was approved in the US and Europe as the only validated option for this indication. Toxicities are usually mild to moderate and can be managed with dose reduction or interruption if necessary. Opportunistic infections and non-infectious pneumonitis are seen as a class effect. Management of common practical management issues are discussed. Clinical trials are in progress to examine additional roles for everolimus in renal cancer, alone and in combination with other agents.Keywords: everolimus, drug therapy, advanced renal cancer Chris CoppinDove Medical PressarticleMedicine (General)R5-920ENBiologics: Targets & Therapy, Vol 2010, Iss default, Pp 91-101 (2010)
institution DOAJ
collection DOAJ
language EN
topic Medicine (General)
R5-920
spellingShingle Medicine (General)
R5-920
Chris Coppin
Everolimus: the first approved product for patients with advanced renal cell cancer after sunitinib and/or sorafenib
description Chris CoppinMedical Oncology, BC Cancer Agency and University of British Columbia, Vancouver, CanadaAbstract: Everolimus (RAD001, Afinitor® Novartis) is the first oral inhibitor of mTOR (mammalian target of rapamycin) to reach the oncology clinic. Everolimus 10 mg daily achieves complete inhibition of its target at below the maximum tolerable dose for most patients. A phase III randomized placebo-controlled trial has examined the impact of everolimus in patients with clear cell renal cancers and progressive disease on or within 6 months of the VEGFR tyrosine kinase inhibitors sunitinib and/or sorafenib. The primary endpoint of progression-free survival was increased from median 1.9 to 4.9 months (hazard ratio 0.33, P < 0.001) and 25% were still progression-free after 10 months of everolimus therapy. There was a delay in time to decline of performance status and trends to improvement in quality of life, disease-related symptoms, and overall survival despite crossover of the majority of patients assigned to placebo. In 2009, everolimus was approved in the US and Europe as the only validated option for this indication. Toxicities are usually mild to moderate and can be managed with dose reduction or interruption if necessary. Opportunistic infections and non-infectious pneumonitis are seen as a class effect. Management of common practical management issues are discussed. Clinical trials are in progress to examine additional roles for everolimus in renal cancer, alone and in combination with other agents.Keywords: everolimus, drug therapy, advanced renal cancer
format article
author Chris Coppin
author_facet Chris Coppin
author_sort Chris Coppin
title Everolimus: the first approved product for patients with advanced renal cell cancer after sunitinib and/or sorafenib
title_short Everolimus: the first approved product for patients with advanced renal cell cancer after sunitinib and/or sorafenib
title_full Everolimus: the first approved product for patients with advanced renal cell cancer after sunitinib and/or sorafenib
title_fullStr Everolimus: the first approved product for patients with advanced renal cell cancer after sunitinib and/or sorafenib
title_full_unstemmed Everolimus: the first approved product for patients with advanced renal cell cancer after sunitinib and/or sorafenib
title_sort everolimus: the first approved product for patients with advanced renal cell cancer after sunitinib and/or sorafenib
publisher Dove Medical Press
publishDate 2010
url https://doaj.org/article/126440ea33894236b7530b0995a5c6eb
work_keys_str_mv AT chriscoppin everolimusthefirstapprovedproductforpatientswithadvancedrenalcellcanceraftersunitinibandorsorafenib
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