Blockade of leukemia inhibitory factor as a therapeutic approach to KRAS driven pancreatic cancer

KRAS mutations are frequent in pancreatic ductal adenocarcinoma, leading to bad prognosis and resistance to targeted therapies. Here, the authors show that LIF expression is specifically induced by KRAS and constitutes a potential target to treat these KRAS-mutated cancers.

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Autores principales:	Man-Tzu Wang, Nicole Fer, Jacqueline Galeas, Eric A. Collisson, Sung Eun Kim, Jeremy Sharib, Frank McCormick
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/1264485d73e0466695383206f5054dba
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spelling	oai:doaj.org-article:1264485d73e0466695383206f5054dba2021-12-02T17:01:32ZBlockade of leukemia inhibitory factor as a therapeutic approach to KRAS driven pancreatic cancer10.1038/s41467-019-11044-92041-1723https://doaj.org/article/1264485d73e0466695383206f5054dba2019-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-11044-9https://doaj.org/toc/2041-1723KRAS mutations are frequent in pancreatic ductal adenocarcinoma, leading to bad prognosis and resistance to targeted therapies. Here, the authors show that LIF expression is specifically induced by KRAS and constitutes a potential target to treat these KRAS-mutated cancers.Man-Tzu WangNicole FerJacqueline GaleasEric A. CollissonSung Eun KimJeremy SharibFrank McCormickNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Man-Tzu Wang Nicole Fer Jacqueline Galeas Eric A. Collisson Sung Eun Kim Jeremy Sharib Frank McCormick Blockade of leukemia inhibitory factor as a therapeutic approach to KRAS driven pancreatic cancer
description	KRAS mutations are frequent in pancreatic ductal adenocarcinoma, leading to bad prognosis and resistance to targeted therapies. Here, the authors show that LIF expression is specifically induced by KRAS and constitutes a potential target to treat these KRAS-mutated cancers.
format	article
author	Man-Tzu Wang Nicole Fer Jacqueline Galeas Eric A. Collisson Sung Eun Kim Jeremy Sharib Frank McCormick
author_facet	Man-Tzu Wang Nicole Fer Jacqueline Galeas Eric A. Collisson Sung Eun Kim Jeremy Sharib Frank McCormick
author_sort	Man-Tzu Wang
title	Blockade of leukemia inhibitory factor as a therapeutic approach to KRAS driven pancreatic cancer
title_short	Blockade of leukemia inhibitory factor as a therapeutic approach to KRAS driven pancreatic cancer
title_full	Blockade of leukemia inhibitory factor as a therapeutic approach to KRAS driven pancreatic cancer
title_fullStr	Blockade of leukemia inhibitory factor as a therapeutic approach to KRAS driven pancreatic cancer
title_full_unstemmed	Blockade of leukemia inhibitory factor as a therapeutic approach to KRAS driven pancreatic cancer
title_sort	blockade of leukemia inhibitory factor as a therapeutic approach to kras driven pancreatic cancer
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/1264485d73e0466695383206f5054dba
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Blockade of leukemia inhibitory factor as a therapeutic approach to KRAS driven pancreatic cancer

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