Mitochondrial bioenergetic, oxidative stress and burrowing responses in earthworm exposed to roxarsone in soil

The eco-risk of roxarsone (ROX) was evaluated using multiple responses of earthworm biomarkers under different ROX concentrations for 28 d. With the increasing total arsenic accumulation (TAs-E), biological responses in earthworm generally showed a two-stage changes of homeostasis dysregulation and...

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Autores principales:	Songge Deng, Hao Tang, Hanqi Duan, Yizhao Wu, Jiangping Qiu, Yinsheng Li
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Eisenia fetida Biomarkers Mitochondrial effects Antioxidant regulation Behavioral toxicity Environmental pollution TD172-193.5 Environmental sciences GE1-350
Acceso en línea:	https://doaj.org/article/12684ff9d5a84153b919f75297c99d55
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spelling	oai:doaj.org-article:12684ff9d5a84153b919f75297c99d552021-11-20T04:55:39ZMitochondrial bioenergetic, oxidative stress and burrowing responses in earthworm exposed to roxarsone in soil0147-651310.1016/j.ecoenv.2021.113003https://doaj.org/article/12684ff9d5a84153b919f75297c99d552021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S0147651321011155https://doaj.org/toc/0147-6513The eco-risk of roxarsone (ROX) was evaluated using multiple responses of earthworm biomarkers under different ROX concentrations for 28 d. With the increasing total arsenic accumulation (TAs-E), biological responses in earthworm generally showed a two-stage changes of homeostasis dysregulation and dose-dependent alterations. At the early periods, ROX stress increased the reactive oxygen species (ROS) and lipid peroxidation (LPO) in a similar manner, and apparently disrupted mitochondrial calcium ([Ca2+]m). But earthworms regulated their mitochondrial and redox homeostasis through stable mitochondrial membrane potential (MMP) and increase of ATP level, superoxide dismutase (SOD) and catalase (CAT). After 14 d, the positively correlated mitochondrial effects of ROS, [Ca2+]m, MMP and ATP were related to the behavioral inhibition of burrow length, depth and reuse rate as well as antioxidant up-regulation of Nrf2, HO-1, sod1 and cat. These results contributed possible biomarkers from the dose-dependent relationship between mitochondrial, antioxidant and behavioral responses. Multiple biological detection in earthworms can better reflect the sub-chronic ecotoxicity of phenylarsenic pollutants in soil.Songge DengHao TangHanqi DuanYizhao WuJiangping QiuYinsheng LiElsevierarticleEisenia fetidaBiomarkersMitochondrial effectsAntioxidant regulationBehavioral toxicityEnvironmental pollutionTD172-193.5Environmental sciencesGE1-350ENEcotoxicology and Environmental Safety, Vol 228, Iss , Pp 113003- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Eisenia fetida Biomarkers Mitochondrial effects Antioxidant regulation Behavioral toxicity Environmental pollution TD172-193.5 Environmental sciences GE1-350
spellingShingle	Eisenia fetida Biomarkers Mitochondrial effects Antioxidant regulation Behavioral toxicity Environmental pollution TD172-193.5 Environmental sciences GE1-350 Songge Deng Hao Tang Hanqi Duan Yizhao Wu Jiangping Qiu Yinsheng Li Mitochondrial bioenergetic, oxidative stress and burrowing responses in earthworm exposed to roxarsone in soil
description	The eco-risk of roxarsone (ROX) was evaluated using multiple responses of earthworm biomarkers under different ROX concentrations for 28 d. With the increasing total arsenic accumulation (TAs-E), biological responses in earthworm generally showed a two-stage changes of homeostasis dysregulation and dose-dependent alterations. At the early periods, ROX stress increased the reactive oxygen species (ROS) and lipid peroxidation (LPO) in a similar manner, and apparently disrupted mitochondrial calcium ([Ca2+]m). But earthworms regulated their mitochondrial and redox homeostasis through stable mitochondrial membrane potential (MMP) and increase of ATP level, superoxide dismutase (SOD) and catalase (CAT). After 14 d, the positively correlated mitochondrial effects of ROS, [Ca2+]m, MMP and ATP were related to the behavioral inhibition of burrow length, depth and reuse rate as well as antioxidant up-regulation of Nrf2, HO-1, sod1 and cat. These results contributed possible biomarkers from the dose-dependent relationship between mitochondrial, antioxidant and behavioral responses. Multiple biological detection in earthworms can better reflect the sub-chronic ecotoxicity of phenylarsenic pollutants in soil.
format	article
author	Songge Deng Hao Tang Hanqi Duan Yizhao Wu Jiangping Qiu Yinsheng Li
author_facet	Songge Deng Hao Tang Hanqi Duan Yizhao Wu Jiangping Qiu Yinsheng Li
author_sort	Songge Deng
title	Mitochondrial bioenergetic, oxidative stress and burrowing responses in earthworm exposed to roxarsone in soil
title_short	Mitochondrial bioenergetic, oxidative stress and burrowing responses in earthworm exposed to roxarsone in soil
title_full	Mitochondrial bioenergetic, oxidative stress and burrowing responses in earthworm exposed to roxarsone in soil
title_fullStr	Mitochondrial bioenergetic, oxidative stress and burrowing responses in earthworm exposed to roxarsone in soil
title_full_unstemmed	Mitochondrial bioenergetic, oxidative stress and burrowing responses in earthworm exposed to roxarsone in soil
title_sort	mitochondrial bioenergetic, oxidative stress and burrowing responses in earthworm exposed to roxarsone in soil
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/12684ff9d5a84153b919f75297c99d55
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Mitochondrial bioenergetic, oxidative stress and burrowing responses in earthworm exposed to roxarsone in soil

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