Regulation of TRIF-mediated innate immune response by K27-linked polyubiquitination and deubiquitination

Regulation of TRIF-mediated innate immune response by K27-linked polyubiquitination and deubiquitination

TRIF is an important adaptor protein for mediating Toll-like receptor (TLR) 3 and TLR4 signaling. Here the authors show that the deubiquitinating enzymes USP19, as well as the E3 ubiquitin ligase complex Cullin-3-Rbx1-KCTD10, modulates TRIF K523 ubiquitination and thereby TRIF recruitment to TLR3/4...

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Autores principales: Xin Wu, Caoqi Lei, Tian Xia, Xuan Zhong, Qing Yang, Hong-Bing Shu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/12696a5c84fc4384b0e426fdaa8451f9
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spelling oai:doaj.org-article:12696a5c84fc4384b0e426fdaa8451f92021-12-02T14:39:40ZRegulation of TRIF-mediated innate immune response by K27-linked polyubiquitination and deubiquitination10.1038/s41467-019-12145-12041-1723https://doaj.org/article/12696a5c84fc4384b0e426fdaa8451f92019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12145-1https://doaj.org/toc/2041-1723TRIF is an important adaptor protein for mediating Toll-like receptor (TLR) 3 and TLR4 signaling. Here the authors show that the deubiquitinating enzymes USP19, as well as the E3 ubiquitin ligase complex Cullin-3-Rbx1-KCTD10, modulates TRIF K523 ubiquitination and thereby TRIF recruitment to TLR3/4 to control innate immunity.Xin WuCaoqi LeiTian XiaXuan ZhongQing YangHong-Bing ShuNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Xin Wu
Caoqi Lei
Tian Xia
Xuan Zhong
Qing Yang
Hong-Bing Shu
Regulation of TRIF-mediated innate immune response by K27-linked polyubiquitination and deubiquitination
description TRIF is an important adaptor protein for mediating Toll-like receptor (TLR) 3 and TLR4 signaling. Here the authors show that the deubiquitinating enzymes USP19, as well as the E3 ubiquitin ligase complex Cullin-3-Rbx1-KCTD10, modulates TRIF K523 ubiquitination and thereby TRIF recruitment to TLR3/4 to control innate immunity.
format article
author Xin Wu
Caoqi Lei
Tian Xia
Xuan Zhong
Qing Yang
Hong-Bing Shu
author_facet Xin Wu
Caoqi Lei
Tian Xia
Xuan Zhong
Qing Yang
Hong-Bing Shu
author_sort Xin Wu
title Regulation of TRIF-mediated innate immune response by K27-linked polyubiquitination and deubiquitination
title_short Regulation of TRIF-mediated innate immune response by K27-linked polyubiquitination and deubiquitination
title_full Regulation of TRIF-mediated innate immune response by K27-linked polyubiquitination and deubiquitination
title_fullStr Regulation of TRIF-mediated innate immune response by K27-linked polyubiquitination and deubiquitination
title_full_unstemmed Regulation of TRIF-mediated innate immune response by K27-linked polyubiquitination and deubiquitination
title_sort regulation of trif-mediated innate immune response by k27-linked polyubiquitination and deubiquitination
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/12696a5c84fc4384b0e426fdaa8451f9
work_keys_str_mv AT xinwu regulationoftrifmediatedinnateimmuneresponsebyk27linkedpolyubiquitinationanddeubiquitination
AT caoqilei regulationoftrifmediatedinnateimmuneresponsebyk27linkedpolyubiquitinationanddeubiquitination
AT tianxia regulationoftrifmediatedinnateimmuneresponsebyk27linkedpolyubiquitinationanddeubiquitination
AT xuanzhong regulationoftrifmediatedinnateimmuneresponsebyk27linkedpolyubiquitinationanddeubiquitination
AT qingyang regulationoftrifmediatedinnateimmuneresponsebyk27linkedpolyubiquitinationanddeubiquitination
AT hongbingshu regulationoftrifmediatedinnateimmuneresponsebyk27linkedpolyubiquitinationanddeubiquitination
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