Working memory-related functional brain patterns in never medicated children with ADHD.

Attention Deficit/Hyperactivity Disorder (ADHD) is a pervasive neurodevelopmental disorder characterized by 3 clusters of age-inappropriate cardinal symptoms: inattention, hyperactivity and impulsivity. These clinical/behavioural symptoms are assumed to result from disturbances within brain systems...

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Autores principales:	Isabelle Massat, Hichem Slama, Martin Kavec, Sylvie Linotte, Alison Mary, Daniele Baleriaux, Thierry Metens, Julien Mendlewicz, Philippe Peigneux
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/126a64a451714a58b1772286364ed4b9
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spelling	oai:doaj.org-article:126a64a451714a58b1772286364ed4b92021-11-18T08:08:44ZWorking memory-related functional brain patterns in never medicated children with ADHD.1932-620310.1371/journal.pone.0049392https://doaj.org/article/126a64a451714a58b1772286364ed4b92012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23166657/?tool=EBIhttps://doaj.org/toc/1932-6203Attention Deficit/Hyperactivity Disorder (ADHD) is a pervasive neurodevelopmental disorder characterized by 3 clusters of age-inappropriate cardinal symptoms: inattention, hyperactivity and impulsivity. These clinical/behavioural symptoms are assumed to result from disturbances within brain systems supporting executive functions including working memory (WM), which refers to the ability to transiently store and flexibly manipulate task-relevant information. Ongoing or past medications, co-morbidity and differences in task performance are potential, independent confounds in assessing the integrity of cerebral patterns in ADHD. In the present study, we recorded WM-related cerebral activity during a memory updating N-back task using functional Magnetic Resonance Imaging (fMRI) in control children and never medicated, prepubescent children with ADHD but without comorbid symptoms. Despite similar updating performance than controls, children with ADHD exhibited decreased, below baseline WM-related activation levels in a widespread cortico-subcortical network encompassing bilateral occipital and inferior parietal areas, caudate nucleus, cerebellum and functionally connected brainstem nuclei. Distinctive functional connectivity patterns were also found in the ADHD in these regions, with a tighter coupling in the updating than in the control condition with a distributed WM-related cerebral network. Especially, cerebellum showed tighter coupling with activity in an area compatible with the brainstem red nucleus. These results in children with clinical core symptoms of ADHD but without comorbid affections and never treated with medication yield evidence for a core functional neuroanatomical network subtending WM-related processes in ADHD, which may participate to the pathophysiology and expression of clinical symptoms.Isabelle MassatHichem SlamaMartin KavecSylvie LinotteAlison MaryDaniele BaleriauxThierry MetensJulien MendlewiczPhilippe PeigneuxPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 11, p e49392 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Isabelle Massat Hichem Slama Martin Kavec Sylvie Linotte Alison Mary Daniele Baleriaux Thierry Metens Julien Mendlewicz Philippe Peigneux Working memory-related functional brain patterns in never medicated children with ADHD.
description	Attention Deficit/Hyperactivity Disorder (ADHD) is a pervasive neurodevelopmental disorder characterized by 3 clusters of age-inappropriate cardinal symptoms: inattention, hyperactivity and impulsivity. These clinical/behavioural symptoms are assumed to result from disturbances within brain systems supporting executive functions including working memory (WM), which refers to the ability to transiently store and flexibly manipulate task-relevant information. Ongoing or past medications, co-morbidity and differences in task performance are potential, independent confounds in assessing the integrity of cerebral patterns in ADHD. In the present study, we recorded WM-related cerebral activity during a memory updating N-back task using functional Magnetic Resonance Imaging (fMRI) in control children and never medicated, prepubescent children with ADHD but without comorbid symptoms. Despite similar updating performance than controls, children with ADHD exhibited decreased, below baseline WM-related activation levels in a widespread cortico-subcortical network encompassing bilateral occipital and inferior parietal areas, caudate nucleus, cerebellum and functionally connected brainstem nuclei. Distinctive functional connectivity patterns were also found in the ADHD in these regions, with a tighter coupling in the updating than in the control condition with a distributed WM-related cerebral network. Especially, cerebellum showed tighter coupling with activity in an area compatible with the brainstem red nucleus. These results in children with clinical core symptoms of ADHD but without comorbid affections and never treated with medication yield evidence for a core functional neuroanatomical network subtending WM-related processes in ADHD, which may participate to the pathophysiology and expression of clinical symptoms.
format	article
author	Isabelle Massat Hichem Slama Martin Kavec Sylvie Linotte Alison Mary Daniele Baleriaux Thierry Metens Julien Mendlewicz Philippe Peigneux
author_facet	Isabelle Massat Hichem Slama Martin Kavec Sylvie Linotte Alison Mary Daniele Baleriaux Thierry Metens Julien Mendlewicz Philippe Peigneux
author_sort	Isabelle Massat
title	Working memory-related functional brain patterns in never medicated children with ADHD.
title_short	Working memory-related functional brain patterns in never medicated children with ADHD.
title_full	Working memory-related functional brain patterns in never medicated children with ADHD.
title_fullStr	Working memory-related functional brain patterns in never medicated children with ADHD.
title_full_unstemmed	Working memory-related functional brain patterns in never medicated children with ADHD.
title_sort	working memory-related functional brain patterns in never medicated children with adhd.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/126a64a451714a58b1772286364ed4b9
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Working memory-related functional brain patterns in never medicated children with ADHD.

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