Sestrins are evolutionarily conserved mediators of exercise benefits

Exercise improves metabolic health and physical condition, particularly important for health in aged individuals. Here, the authors identify that Sestrins, proteins induced by exercise, are key mediators of the metabolic adaptation to exercise and increase endurance through the AKT and PGC1a axes.

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Autores principales:	Myungjin Kim, Alyson Sujkowski, Sim Namkoong, Bondong Gu, Tyler Cobb, Boyoung Kim, Allison H. Kowalsky, Chun-Seok Cho, Ian Semple, Seung-Hyun Ro, Carol Davis, Susan V. Brooks, Michael Karin, Robert J. Wessells, Jun Hee Lee
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/126b3fa1af5449268749287ab60d04c0
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spelling	oai:doaj.org-article:126b3fa1af5449268749287ab60d04c02021-12-02T15:34:35ZSestrins are evolutionarily conserved mediators of exercise benefits10.1038/s41467-019-13442-52041-1723https://doaj.org/article/126b3fa1af5449268749287ab60d04c02020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13442-5https://doaj.org/toc/2041-1723Exercise improves metabolic health and physical condition, particularly important for health in aged individuals. Here, the authors identify that Sestrins, proteins induced by exercise, are key mediators of the metabolic adaptation to exercise and increase endurance through the AKT and PGC1a axes.Myungjin KimAlyson SujkowskiSim NamkoongBondong GuTyler CobbBoyoung KimAllison H. KowalskyChun-Seok ChoIan SempleSeung-Hyun RoCarol DavisSusan V. BrooksMichael KarinRobert J. WessellsJun Hee LeeNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Myungjin Kim Alyson Sujkowski Sim Namkoong Bondong Gu Tyler Cobb Boyoung Kim Allison H. Kowalsky Chun-Seok Cho Ian Semple Seung-Hyun Ro Carol Davis Susan V. Brooks Michael Karin Robert J. Wessells Jun Hee Lee Sestrins are evolutionarily conserved mediators of exercise benefits
description	Exercise improves metabolic health and physical condition, particularly important for health in aged individuals. Here, the authors identify that Sestrins, proteins induced by exercise, are key mediators of the metabolic adaptation to exercise and increase endurance through the AKT and PGC1a axes.
format	article
author	Myungjin Kim Alyson Sujkowski Sim Namkoong Bondong Gu Tyler Cobb Boyoung Kim Allison H. Kowalsky Chun-Seok Cho Ian Semple Seung-Hyun Ro Carol Davis Susan V. Brooks Michael Karin Robert J. Wessells Jun Hee Lee
author_facet	Myungjin Kim Alyson Sujkowski Sim Namkoong Bondong Gu Tyler Cobb Boyoung Kim Allison H. Kowalsky Chun-Seok Cho Ian Semple Seung-Hyun Ro Carol Davis Susan V. Brooks Michael Karin Robert J. Wessells Jun Hee Lee
author_sort	Myungjin Kim
title	Sestrins are evolutionarily conserved mediators of exercise benefits
title_short	Sestrins are evolutionarily conserved mediators of exercise benefits
title_full	Sestrins are evolutionarily conserved mediators of exercise benefits
title_fullStr	Sestrins are evolutionarily conserved mediators of exercise benefits
title_full_unstemmed	Sestrins are evolutionarily conserved mediators of exercise benefits
title_sort	sestrins are evolutionarily conserved mediators of exercise benefits
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/126b3fa1af5449268749287ab60d04c0
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Sestrins are evolutionarily conserved mediators of exercise benefits

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