Effect of Lactobacillus plantarum LS/07 on Intestinal Bacterial Enzyme Activities in the Prevention of Cancer, Atherosclerosis and Dysbiosis

The effect of the probiotic strain Lactobacillus plantarum LS/07 on intestinal bacterial enzyme activities – β-glucuronidase (β-GLUCUR), β-galactosidase (β-GAL), and β-glucosidase (β-GLU) in the prevention of cancer, atherosclerosis and dysbiosis was investigated. Male Sprague-Dawley rats were rando...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Hijová Emília, Kuzma Jozef, Strojný Ladislav, Bomba Alojz, Bertková Izabela, Chmelárová Anna, Hertelyová Zdena, Kuliková Lucia, Štofilová Jana, Ambro Ľuboš
Formato:	article
Lenguaje:	EN
Publicado:	Sciendo 2016
Materias:	sprague-dawley rats bacterial enzyme cancer atherosclerosis dysbiosis Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/127c484320f1498290bcddaf67c07d5b
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:127c484320f1498290bcddaf67c07d5b
record_format	dspace
spelling	oai:doaj.org-article:127c484320f1498290bcddaf67c07d5b2021-11-17T21:27:51ZEffect of Lactobacillus plantarum LS/07 on Intestinal Bacterial Enzyme Activities in the Prevention of Cancer, Atherosclerosis and Dysbiosis1820-744810.1515/acve-2016-0026https://doaj.org/article/127c484320f1498290bcddaf67c07d5b2016-09-01T00:00:00Zhttps://doi.org/10.1515/acve-2016-0026https://doaj.org/toc/1820-7448The effect of the probiotic strain Lactobacillus plantarum LS/07 on intestinal bacterial enzyme activities – β-glucuronidase (β-GLUCUR), β-galactosidase (β-GAL), and β-glucosidase (β-GLU) in the prevention of cancer, atherosclerosis and dysbiosis was investigated. Male Sprague-Dawley rats were randomly divided into 12 experimental groups: C (control group), AT (atherosclerotic group), CC (carcinogenic group), and then each group in combination with antibiotics and probiotics individually and each group in double combination on antibiotic and probiotic. In the control group the β-glucuronidase activity did not change throughout the experiment. High fat diet in the atherosclerotic group significantly increased the activity of β-glucuronidase (p<0.001) and β-glucosidase (p<0.01). Azoxymethane application in the carcinogenic group significantly increased β-glucuronidase (p<0.01), but reduced β-glucosidase (p<0.01). Daily application of probiotics individually and in double combination with antibiotics increased the activity of β-galactosidase, and β-glucosidase, and positively decreased the level of β-glucuronidase. In the control antibiotic group β-glucuronidase was significantly increased (p<0.05), and β-glucosidase decreased (p<0.01) which can be caused by a change of microflora in favor of coliform bacteria. These finding indicate the positive effects of probiotic Lactobacillus plantarum LS/07 which allows its use in disease prevention in human and veterinary medicine.Hijová EmíliaKuzma JozefStrojný LadislavBomba AlojzBertková IzabelaChmelárová AnnaHertelyová ZdenaKuliková LuciaŠtofilová JanaAmbro ĽubošSciendoarticlesprague-dawley ratsbacterial enzymecanceratherosclerosisdysbiosisVeterinary medicineSF600-1100ENActa Veterinaria, Vol 66, Iss 3, Pp 294-303 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	sprague-dawley rats bacterial enzyme cancer atherosclerosis dysbiosis Veterinary medicine SF600-1100
spellingShingle	sprague-dawley rats bacterial enzyme cancer atherosclerosis dysbiosis Veterinary medicine SF600-1100 Hijová Emília Kuzma Jozef Strojný Ladislav Bomba Alojz Bertková Izabela Chmelárová Anna Hertelyová Zdena Kuliková Lucia Štofilová Jana Ambro Ľuboš Effect of Lactobacillus plantarum LS/07 on Intestinal Bacterial Enzyme Activities in the Prevention of Cancer, Atherosclerosis and Dysbiosis
description	The effect of the probiotic strain Lactobacillus plantarum LS/07 on intestinal bacterial enzyme activities – β-glucuronidase (β-GLUCUR), β-galactosidase (β-GAL), and β-glucosidase (β-GLU) in the prevention of cancer, atherosclerosis and dysbiosis was investigated. Male Sprague-Dawley rats were randomly divided into 12 experimental groups: C (control group), AT (atherosclerotic group), CC (carcinogenic group), and then each group in combination with antibiotics and probiotics individually and each group in double combination on antibiotic and probiotic. In the control group the β-glucuronidase activity did not change throughout the experiment. High fat diet in the atherosclerotic group significantly increased the activity of β-glucuronidase (p<0.001) and β-glucosidase (p<0.01). Azoxymethane application in the carcinogenic group significantly increased β-glucuronidase (p<0.01), but reduced β-glucosidase (p<0.01). Daily application of probiotics individually and in double combination with antibiotics increased the activity of β-galactosidase, and β-glucosidase, and positively decreased the level of β-glucuronidase. In the control antibiotic group β-glucuronidase was significantly increased (p<0.05), and β-glucosidase decreased (p<0.01) which can be caused by a change of microflora in favor of coliform bacteria. These finding indicate the positive effects of probiotic Lactobacillus plantarum LS/07 which allows its use in disease prevention in human and veterinary medicine.
format	article
author	Hijová Emília Kuzma Jozef Strojný Ladislav Bomba Alojz Bertková Izabela Chmelárová Anna Hertelyová Zdena Kuliková Lucia Štofilová Jana Ambro Ľuboš
author_facet	Hijová Emília Kuzma Jozef Strojný Ladislav Bomba Alojz Bertková Izabela Chmelárová Anna Hertelyová Zdena Kuliková Lucia Štofilová Jana Ambro Ľuboš
author_sort	Hijová Emília
title	Effect of Lactobacillus plantarum LS/07 on Intestinal Bacterial Enzyme Activities in the Prevention of Cancer, Atherosclerosis and Dysbiosis
title_short	Effect of Lactobacillus plantarum LS/07 on Intestinal Bacterial Enzyme Activities in the Prevention of Cancer, Atherosclerosis and Dysbiosis
title_full	Effect of Lactobacillus plantarum LS/07 on Intestinal Bacterial Enzyme Activities in the Prevention of Cancer, Atherosclerosis and Dysbiosis
title_fullStr	Effect of Lactobacillus plantarum LS/07 on Intestinal Bacterial Enzyme Activities in the Prevention of Cancer, Atherosclerosis and Dysbiosis
title_full_unstemmed	Effect of Lactobacillus plantarum LS/07 on Intestinal Bacterial Enzyme Activities in the Prevention of Cancer, Atherosclerosis and Dysbiosis
title_sort	effect of lactobacillus plantarum ls/07 on intestinal bacterial enzyme activities in the prevention of cancer, atherosclerosis and dysbiosis
publisher	Sciendo
publishDate	2016
url	https://doaj.org/article/127c484320f1498290bcddaf67c07d5b
work_keys_str_mv	AT hijovaemilia effectoflactobacillusplantarumls07onintestinalbacterialenzymeactivitiesinthepreventionofcanceratherosclerosisanddysbiosis AT kuzmajozef effectoflactobacillusplantarumls07onintestinalbacterialenzymeactivitiesinthepreventionofcanceratherosclerosisanddysbiosis AT strojnyladislav effectoflactobacillusplantarumls07onintestinalbacterialenzymeactivitiesinthepreventionofcanceratherosclerosisanddysbiosis AT bombaalojz effectoflactobacillusplantarumls07onintestinalbacterialenzymeactivitiesinthepreventionofcanceratherosclerosisanddysbiosis AT bertkovaizabela effectoflactobacillusplantarumls07onintestinalbacterialenzymeactivitiesinthepreventionofcanceratherosclerosisanddysbiosis AT chmelarovaanna effectoflactobacillusplantarumls07onintestinalbacterialenzymeactivitiesinthepreventionofcanceratherosclerosisanddysbiosis AT hertelyovazdena effectoflactobacillusplantarumls07onintestinalbacterialenzymeactivitiesinthepreventionofcanceratherosclerosisanddysbiosis AT kulikovalucia effectoflactobacillusplantarumls07onintestinalbacterialenzymeactivitiesinthepreventionofcanceratherosclerosisanddysbiosis AT stofilovajana effectoflactobacillusplantarumls07onintestinalbacterialenzymeactivitiesinthepreventionofcanceratherosclerosisanddysbiosis AT ambrolubos effectoflactobacillusplantarumls07onintestinalbacterialenzymeactivitiesinthepreventionofcanceratherosclerosisanddysbiosis
_version_	1718425335537598464

Effect of Lactobacillus plantarum LS/07 on Intestinal Bacterial Enzyme Activities in the Prevention of Cancer, Atherosclerosis and Dysbiosis

Ejemplares similares