Bioactive Compounds and Nanodelivery Perspectives for Treatment of Cardiovascular Diseases

Bioactive compounds are comprised of small quantities of extra nutritional constituents providing both health benefits and enhanced nutritional value, based on their ability to modulate one or more metabolic processes. Plant-based diets are being thoroughly researched for their cardiovascular proper...

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Autores principales:	Rakesh K. Sindhu, Annima Goyal, Evren Algın Yapar, Simona Cavalu
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	bioactive compounds cardiovascular nanodelivery bioavailability Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/127dd05075cf439d859809af2055da91
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spelling	oai:doaj.org-article:127dd05075cf439d859809af2055da912021-11-25T16:43:07ZBioactive Compounds and Nanodelivery Perspectives for Treatment of Cardiovascular Diseases10.3390/app1122110312076-3417https://doaj.org/article/127dd05075cf439d859809af2055da912021-11-01T00:00:00Zhttps://www.mdpi.com/2076-3417/11/22/11031https://doaj.org/toc/2076-3417Bioactive compounds are comprised of small quantities of extra nutritional constituents providing both health benefits and enhanced nutritional value, based on their ability to modulate one or more metabolic processes. Plant-based diets are being thoroughly researched for their cardiovascular properties and effectiveness against cancer. Flavonoids, phytoestrogens, phenolic compounds, and carotenoids are some of the bioactive compounds that aim to work in prevention and treating the cardiovascular disease in a systemic manner, including hypertension, atherosclerosis, and heart failure. Their antioxidant and anti-inflammatory properties are the most important characteristics that make them favorable candidates for CVDs treatment. However, their low water solubility and stability results in low bioavailability, limited accessibility, and poor absorption. The oral delivery of bioactive compounds is constrained due to physiological barriers such as the pH, mucus layer, gastrointestinal enzymes, epithelium, etc. The present review aims to revise the main bioactive compounds with a significant role in CVDs in terms of preventive, diagnostic, and treatment measures. The advantages of nanoformulations and novel multifunctional nanomaterials development are described in order to overcome multiple obstacles, including the physiological ones, by summarizing the most recent preclinical data and clinical trials reported in the literature. Nanotechnologies will open a new window in the area of CVDs with the opportunity to achieve effective treatment, better prognosis, and less adverse effects on non-target tissues.Rakesh K. SindhuAnnima GoyalEvren Algın YaparSimona CavaluMDPI AGarticlebioactive compoundscardiovascularnanodeliverybioavailabilityTechnologyTEngineering (General). Civil engineering (General)TA1-2040Biology (General)QH301-705.5PhysicsQC1-999ChemistryQD1-999ENApplied Sciences, Vol 11, Iss 11031, p 11031 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	bioactive compounds cardiovascular nanodelivery bioavailability Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999
spellingShingle	bioactive compounds cardiovascular nanodelivery bioavailability Technology T Engineering (General). Civil engineering (General) TA1-2040 Biology (General) QH301-705.5 Physics QC1-999 Chemistry QD1-999 Rakesh K. Sindhu Annima Goyal Evren Algın Yapar Simona Cavalu Bioactive Compounds and Nanodelivery Perspectives for Treatment of Cardiovascular Diseases
description	Bioactive compounds are comprised of small quantities of extra nutritional constituents providing both health benefits and enhanced nutritional value, based on their ability to modulate one or more metabolic processes. Plant-based diets are being thoroughly researched for their cardiovascular properties and effectiveness against cancer. Flavonoids, phytoestrogens, phenolic compounds, and carotenoids are some of the bioactive compounds that aim to work in prevention and treating the cardiovascular disease in a systemic manner, including hypertension, atherosclerosis, and heart failure. Their antioxidant and anti-inflammatory properties are the most important characteristics that make them favorable candidates for CVDs treatment. However, their low water solubility and stability results in low bioavailability, limited accessibility, and poor absorption. The oral delivery of bioactive compounds is constrained due to physiological barriers such as the pH, mucus layer, gastrointestinal enzymes, epithelium, etc. The present review aims to revise the main bioactive compounds with a significant role in CVDs in terms of preventive, diagnostic, and treatment measures. The advantages of nanoformulations and novel multifunctional nanomaterials development are described in order to overcome multiple obstacles, including the physiological ones, by summarizing the most recent preclinical data and clinical trials reported in the literature. Nanotechnologies will open a new window in the area of CVDs with the opportunity to achieve effective treatment, better prognosis, and less adverse effects on non-target tissues.
format	article
author	Rakesh K. Sindhu Annima Goyal Evren Algın Yapar Simona Cavalu
author_facet	Rakesh K. Sindhu Annima Goyal Evren Algın Yapar Simona Cavalu
author_sort	Rakesh K. Sindhu
title	Bioactive Compounds and Nanodelivery Perspectives for Treatment of Cardiovascular Diseases
title_short	Bioactive Compounds and Nanodelivery Perspectives for Treatment of Cardiovascular Diseases
title_full	Bioactive Compounds and Nanodelivery Perspectives for Treatment of Cardiovascular Diseases
title_fullStr	Bioactive Compounds and Nanodelivery Perspectives for Treatment of Cardiovascular Diseases
title_full_unstemmed	Bioactive Compounds and Nanodelivery Perspectives for Treatment of Cardiovascular Diseases
title_sort	bioactive compounds and nanodelivery perspectives for treatment of cardiovascular diseases
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/127dd05075cf439d859809af2055da91
work_keys_str_mv	AT rakeshksindhu bioactivecompoundsandnanodeliveryperspectivesfortreatmentofcardiovasculardiseases AT annimagoyal bioactivecompoundsandnanodeliveryperspectivesfortreatmentofcardiovasculardiseases AT evrenalgınyapar bioactivecompoundsandnanodeliveryperspectivesfortreatmentofcardiovasculardiseases AT simonacavalu bioactivecompoundsandnanodeliveryperspectivesfortreatmentofcardiovasculardiseases
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Bioactive Compounds and Nanodelivery Perspectives for Treatment of Cardiovascular Diseases

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