Endocrine lineage biases arise in temporally distinct endocrine progenitors during pancreatic morphogenesis

Endocrine progenitors form early in pancreatic development but the diversity of this cell population is unclear. Here, the authors use single cell RNA sequencing of the mouse pancreas at e14.5 and e16.5 to show that endocrine progenitors are temporally distinct and those formed later are more likely...

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Autores principales:	Marissa A. Scavuzzo, Matthew C. Hill, Jolanta Chmielowiec, Diane Yang, Jessica Teaw, Kuanwei Sheng, Yuelin Kong, Maria Bettini, Chenghang Zong, James F. Martin, Malgorzata Borowiak
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/128732b885f1499aabecf3b2fb56b522
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spelling	oai:doaj.org-article:128732b885f1499aabecf3b2fb56b5222021-12-02T15:33:47ZEndocrine lineage biases arise in temporally distinct endocrine progenitors during pancreatic morphogenesis10.1038/s41467-018-05740-12041-1723https://doaj.org/article/128732b885f1499aabecf3b2fb56b5222018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05740-1https://doaj.org/toc/2041-1723Endocrine progenitors form early in pancreatic development but the diversity of this cell population is unclear. Here, the authors use single cell RNA sequencing of the mouse pancreas at e14.5 and e16.5 to show that endocrine progenitors are temporally distinct and those formed later are more likely to become beta cellsMarissa A. ScavuzzoMatthew C. HillJolanta ChmielowiecDiane YangJessica TeawKuanwei ShengYuelin KongMaria BettiniChenghang ZongJames F. MartinMalgorzata BorowiakNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-21 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Marissa A. Scavuzzo Matthew C. Hill Jolanta Chmielowiec Diane Yang Jessica Teaw Kuanwei Sheng Yuelin Kong Maria Bettini Chenghang Zong James F. Martin Malgorzata Borowiak Endocrine lineage biases arise in temporally distinct endocrine progenitors during pancreatic morphogenesis
description	Endocrine progenitors form early in pancreatic development but the diversity of this cell population is unclear. Here, the authors use single cell RNA sequencing of the mouse pancreas at e14.5 and e16.5 to show that endocrine progenitors are temporally distinct and those formed later are more likely to become beta cells
format	article
author	Marissa A. Scavuzzo Matthew C. Hill Jolanta Chmielowiec Diane Yang Jessica Teaw Kuanwei Sheng Yuelin Kong Maria Bettini Chenghang Zong James F. Martin Malgorzata Borowiak
author_facet	Marissa A. Scavuzzo Matthew C. Hill Jolanta Chmielowiec Diane Yang Jessica Teaw Kuanwei Sheng Yuelin Kong Maria Bettini Chenghang Zong James F. Martin Malgorzata Borowiak
author_sort	Marissa A. Scavuzzo
title	Endocrine lineage biases arise in temporally distinct endocrine progenitors during pancreatic morphogenesis
title_short	Endocrine lineage biases arise in temporally distinct endocrine progenitors during pancreatic morphogenesis
title_full	Endocrine lineage biases arise in temporally distinct endocrine progenitors during pancreatic morphogenesis
title_fullStr	Endocrine lineage biases arise in temporally distinct endocrine progenitors during pancreatic morphogenesis
title_full_unstemmed	Endocrine lineage biases arise in temporally distinct endocrine progenitors during pancreatic morphogenesis
title_sort	endocrine lineage biases arise in temporally distinct endocrine progenitors during pancreatic morphogenesis
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/128732b885f1499aabecf3b2fb56b522
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Endocrine lineage biases arise in temporally distinct endocrine progenitors during pancreatic morphogenesis

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