Maternal DNMT3A-dependent de novo methylation of the paternal genome inhibits gene expression in the early embryo
The paternal genome in mice undergoes widespread DNA methylation loss post-fertilization. Here, the authors apply allele-specific analysis of WGBS data to show that a number of genomic regions are simultaneously de novo methylated on the paternal genome dependent on maternal DNMT3A activity, which i...
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Nature Portfolio
2020
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oai:doaj.org-article:128797e6956e467bae7bb0618d815a9b2021-12-02T14:42:28ZMaternal DNMT3A-dependent de novo methylation of the paternal genome inhibits gene expression in the early embryo10.1038/s41467-020-19279-72041-1723https://doaj.org/article/128797e6956e467bae7bb0618d815a9b2020-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19279-7https://doaj.org/toc/2041-1723The paternal genome in mice undergoes widespread DNA methylation loss post-fertilization. Here, the authors apply allele-specific analysis of WGBS data to show that a number of genomic regions are simultaneously de novo methylated on the paternal genome dependent on maternal DNMT3A activity, which induces transcriptional silencing of this allele in the early embryo.Julien Richard AlbertWan Kin Au YeungKeisuke ToriyamaHisato KobayashiRyutaro HirasawaJulie Brind’AmourAaron BogutzHiroyuki SasakiMatthew LorinczNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020) |
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Science Q Julien Richard Albert Wan Kin Au Yeung Keisuke Toriyama Hisato Kobayashi Ryutaro Hirasawa Julie Brind’Amour Aaron Bogutz Hiroyuki Sasaki Matthew Lorincz Maternal DNMT3A-dependent de novo methylation of the paternal genome inhibits gene expression in the early embryo |
description |
The paternal genome in mice undergoes widespread DNA methylation loss post-fertilization. Here, the authors apply allele-specific analysis of WGBS data to show that a number of genomic regions are simultaneously de novo methylated on the paternal genome dependent on maternal DNMT3A activity, which induces transcriptional silencing of this allele in the early embryo. |
format |
article |
author |
Julien Richard Albert Wan Kin Au Yeung Keisuke Toriyama Hisato Kobayashi Ryutaro Hirasawa Julie Brind’Amour Aaron Bogutz Hiroyuki Sasaki Matthew Lorincz |
author_facet |
Julien Richard Albert Wan Kin Au Yeung Keisuke Toriyama Hisato Kobayashi Ryutaro Hirasawa Julie Brind’Amour Aaron Bogutz Hiroyuki Sasaki Matthew Lorincz |
author_sort |
Julien Richard Albert |
title |
Maternal DNMT3A-dependent de novo methylation of the paternal genome inhibits gene expression in the early embryo |
title_short |
Maternal DNMT3A-dependent de novo methylation of the paternal genome inhibits gene expression in the early embryo |
title_full |
Maternal DNMT3A-dependent de novo methylation of the paternal genome inhibits gene expression in the early embryo |
title_fullStr |
Maternal DNMT3A-dependent de novo methylation of the paternal genome inhibits gene expression in the early embryo |
title_full_unstemmed |
Maternal DNMT3A-dependent de novo methylation of the paternal genome inhibits gene expression in the early embryo |
title_sort |
maternal dnmt3a-dependent de novo methylation of the paternal genome inhibits gene expression in the early embryo |
publisher |
Nature Portfolio |
publishDate |
2020 |
url |
https://doaj.org/article/128797e6956e467bae7bb0618d815a9b |
work_keys_str_mv |
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1718389673390243840 |