Maternal DNMT3A-dependent de novo methylation of the paternal genome inhibits gene expression in the early embryo

The paternal genome in mice undergoes widespread DNA methylation loss post-fertilization. Here, the authors apply allele-specific analysis of WGBS data to show that a number of genomic regions are simultaneously de novo methylated on the paternal genome dependent on maternal DNMT3A activity, which i...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Julien Richard Albert, Wan Kin Au Yeung, Keisuke Toriyama, Hisato Kobayashi, Ryutaro Hirasawa, Julie Brind’Amour, Aaron Bogutz, Hiroyuki Sasaki, Matthew Lorincz
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
Materias:
Q
Acceso en línea:https://doaj.org/article/128797e6956e467bae7bb0618d815a9b
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:128797e6956e467bae7bb0618d815a9b
record_format dspace
spelling oai:doaj.org-article:128797e6956e467bae7bb0618d815a9b2021-12-02T14:42:28ZMaternal DNMT3A-dependent de novo methylation of the paternal genome inhibits gene expression in the early embryo10.1038/s41467-020-19279-72041-1723https://doaj.org/article/128797e6956e467bae7bb0618d815a9b2020-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19279-7https://doaj.org/toc/2041-1723The paternal genome in mice undergoes widespread DNA methylation loss post-fertilization. Here, the authors apply allele-specific analysis of WGBS data to show that a number of genomic regions are simultaneously de novo methylated on the paternal genome dependent on maternal DNMT3A activity, which induces transcriptional silencing of this allele in the early embryo.Julien Richard AlbertWan Kin Au YeungKeisuke ToriyamaHisato KobayashiRyutaro HirasawaJulie Brind’AmourAaron BogutzHiroyuki SasakiMatthew LorinczNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Julien Richard Albert
Wan Kin Au Yeung
Keisuke Toriyama
Hisato Kobayashi
Ryutaro Hirasawa
Julie Brind’Amour
Aaron Bogutz
Hiroyuki Sasaki
Matthew Lorincz
Maternal DNMT3A-dependent de novo methylation of the paternal genome inhibits gene expression in the early embryo
description The paternal genome in mice undergoes widespread DNA methylation loss post-fertilization. Here, the authors apply allele-specific analysis of WGBS data to show that a number of genomic regions are simultaneously de novo methylated on the paternal genome dependent on maternal DNMT3A activity, which induces transcriptional silencing of this allele in the early embryo.
format article
author Julien Richard Albert
Wan Kin Au Yeung
Keisuke Toriyama
Hisato Kobayashi
Ryutaro Hirasawa
Julie Brind’Amour
Aaron Bogutz
Hiroyuki Sasaki
Matthew Lorincz
author_facet Julien Richard Albert
Wan Kin Au Yeung
Keisuke Toriyama
Hisato Kobayashi
Ryutaro Hirasawa
Julie Brind’Amour
Aaron Bogutz
Hiroyuki Sasaki
Matthew Lorincz
author_sort Julien Richard Albert
title Maternal DNMT3A-dependent de novo methylation of the paternal genome inhibits gene expression in the early embryo
title_short Maternal DNMT3A-dependent de novo methylation of the paternal genome inhibits gene expression in the early embryo
title_full Maternal DNMT3A-dependent de novo methylation of the paternal genome inhibits gene expression in the early embryo
title_fullStr Maternal DNMT3A-dependent de novo methylation of the paternal genome inhibits gene expression in the early embryo
title_full_unstemmed Maternal DNMT3A-dependent de novo methylation of the paternal genome inhibits gene expression in the early embryo
title_sort maternal dnmt3a-dependent de novo methylation of the paternal genome inhibits gene expression in the early embryo
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/128797e6956e467bae7bb0618d815a9b
work_keys_str_mv AT julienrichardalbert maternaldnmt3adependentdenovomethylationofthepaternalgenomeinhibitsgeneexpressionintheearlyembryo
AT wankinauyeung maternaldnmt3adependentdenovomethylationofthepaternalgenomeinhibitsgeneexpressionintheearlyembryo
AT keisuketoriyama maternaldnmt3adependentdenovomethylationofthepaternalgenomeinhibitsgeneexpressionintheearlyembryo
AT hisatokobayashi maternaldnmt3adependentdenovomethylationofthepaternalgenomeinhibitsgeneexpressionintheearlyembryo
AT ryutarohirasawa maternaldnmt3adependentdenovomethylationofthepaternalgenomeinhibitsgeneexpressionintheearlyembryo
AT juliebrindamour maternaldnmt3adependentdenovomethylationofthepaternalgenomeinhibitsgeneexpressionintheearlyembryo
AT aaronbogutz maternaldnmt3adependentdenovomethylationofthepaternalgenomeinhibitsgeneexpressionintheearlyembryo
AT hiroyukisasaki maternaldnmt3adependentdenovomethylationofthepaternalgenomeinhibitsgeneexpressionintheearlyembryo
AT matthewlorincz maternaldnmt3adependentdenovomethylationofthepaternalgenomeinhibitsgeneexpressionintheearlyembryo
_version_ 1718389673390243840