Targeting chondrocytes for arresting bony fusion in ankylosing spondylitis

Current treatments cannot significantly alleviate the radiographic progression in ankylosing spondylitis (AS), which results in joints stiffness and bony fusion of AS. Smo inhibitor sonidegib retards the pathological new bone formation in AS through targeting dysfunctional chondrogenesis.

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Autores principales:	Fenli Shao, Qianqian Liu, Yuyu Zhu, Zhidan Fan, Wenjun Chen, Shijia Liu, Xiaohui Li, Wenjie Guo, Gen-Sheng Feng, Haiguo Yu, Qiang Xu, Yang Sun
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/12886a3b76044df8b6656dcdbe796a6e
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spelling	oai:doaj.org-article:12886a3b76044df8b6656dcdbe796a6e2021-11-14T12:34:30ZTargeting chondrocytes for arresting bony fusion in ankylosing spondylitis10.1038/s41467-021-26750-62041-1723https://doaj.org/article/12886a3b76044df8b6656dcdbe796a6e2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26750-6https://doaj.org/toc/2041-1723Current treatments cannot significantly alleviate the radiographic progression in ankylosing spondylitis (AS), which results in joints stiffness and bony fusion of AS. Smo inhibitor sonidegib retards the pathological new bone formation in AS through targeting dysfunctional chondrogenesis.Fenli ShaoQianqian LiuYuyu ZhuZhidan FanWenjun ChenShijia LiuXiaohui LiWenjie GuoGen-Sheng FengHaiguo YuQiang XuYang SunNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Fenli Shao Qianqian Liu Yuyu Zhu Zhidan Fan Wenjun Chen Shijia Liu Xiaohui Li Wenjie Guo Gen-Sheng Feng Haiguo Yu Qiang Xu Yang Sun Targeting chondrocytes for arresting bony fusion in ankylosing spondylitis
description	Current treatments cannot significantly alleviate the radiographic progression in ankylosing spondylitis (AS), which results in joints stiffness and bony fusion of AS. Smo inhibitor sonidegib retards the pathological new bone formation in AS through targeting dysfunctional chondrogenesis.
format	article
author	Fenli Shao Qianqian Liu Yuyu Zhu Zhidan Fan Wenjun Chen Shijia Liu Xiaohui Li Wenjie Guo Gen-Sheng Feng Haiguo Yu Qiang Xu Yang Sun
author_facet	Fenli Shao Qianqian Liu Yuyu Zhu Zhidan Fan Wenjun Chen Shijia Liu Xiaohui Li Wenjie Guo Gen-Sheng Feng Haiguo Yu Qiang Xu Yang Sun
author_sort	Fenli Shao
title	Targeting chondrocytes for arresting bony fusion in ankylosing spondylitis
title_short	Targeting chondrocytes for arresting bony fusion in ankylosing spondylitis
title_full	Targeting chondrocytes for arresting bony fusion in ankylosing spondylitis
title_fullStr	Targeting chondrocytes for arresting bony fusion in ankylosing spondylitis
title_full_unstemmed	Targeting chondrocytes for arresting bony fusion in ankylosing spondylitis
title_sort	targeting chondrocytes for arresting bony fusion in ankylosing spondylitis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/12886a3b76044df8b6656dcdbe796a6e
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Targeting chondrocytes for arresting bony fusion in ankylosing spondylitis

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