Low muscle strength and increased arterial stiffness go hand in hand

Abstract Low handgrip strength and increased arterial stiffness are both associated with poor health outcomes, but evidence on the relationship between handgrip strength and arterial stiffness is limited. In this cross-sectional analysis of combined baseline datasets from the LipidCardio and Berlin...

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Autores principales:	Maximilian König, Nikolaus Buchmann, Ute Seeland, Dominik Spira, Elisabeth Steinhagen-Thiessen, Ilja Demuth
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/128a240ab93b4173a781fc94f1279241
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spelling	oai:doaj.org-article:128a240ab93b4173a781fc94f12792412021-12-02T10:44:09ZLow muscle strength and increased arterial stiffness go hand in hand10.1038/s41598-021-81084-z2045-2322https://doaj.org/article/128a240ab93b4173a781fc94f12792412021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-81084-zhttps://doaj.org/toc/2045-2322Abstract Low handgrip strength and increased arterial stiffness are both associated with poor health outcomes, but evidence on the relationship between handgrip strength and arterial stiffness is limited. In this cross-sectional analysis of combined baseline datasets from the LipidCardio and Berlin Aging Study II cohorts we aimed to examine whether handgrip strength (HGS) is associated with arterial stiffness. 1511 participants with a median age of 68.56 (IQR 63.13–73.08) years were included. Arterial stiffness was assessed by aortal pulse wave velocity (PWV) with the Mobil-O-Graph device. Handgrip strength was assessed with a handheld dynamometer. The mean HGS was 39.05 ± 9.07 kg in men and 26.20 ± 7.47 kg in women. According to multivariable linear regression analysis per 5 kg decrease in handgrip strength there was a mean increase in PWV of 0.08 m/s after adjustment for the confounders age, sex, coronary artery disease, systolic blood pressure, body mass index, cohort, and smoking. Thus, there was evidence that low handgrip strength and increased arterial stiffness go hand in hand. Arterial stiffness can possibly create the missing link between low handgrip strength and increased cardiovascular morbidity and mortality. Causality and direction of causality remain to be determined.Maximilian KönigNikolaus BuchmannUte SeelandDominik SpiraElisabeth Steinhagen-ThiessenIlja DemuthNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Maximilian König Nikolaus Buchmann Ute Seeland Dominik Spira Elisabeth Steinhagen-Thiessen Ilja Demuth Low muscle strength and increased arterial stiffness go hand in hand
description	Abstract Low handgrip strength and increased arterial stiffness are both associated with poor health outcomes, but evidence on the relationship between handgrip strength and arterial stiffness is limited. In this cross-sectional analysis of combined baseline datasets from the LipidCardio and Berlin Aging Study II cohorts we aimed to examine whether handgrip strength (HGS) is associated with arterial stiffness. 1511 participants with a median age of 68.56 (IQR 63.13–73.08) years were included. Arterial stiffness was assessed by aortal pulse wave velocity (PWV) with the Mobil-O-Graph device. Handgrip strength was assessed with a handheld dynamometer. The mean HGS was 39.05 ± 9.07 kg in men and 26.20 ± 7.47 kg in women. According to multivariable linear regression analysis per 5 kg decrease in handgrip strength there was a mean increase in PWV of 0.08 m/s after adjustment for the confounders age, sex, coronary artery disease, systolic blood pressure, body mass index, cohort, and smoking. Thus, there was evidence that low handgrip strength and increased arterial stiffness go hand in hand. Arterial stiffness can possibly create the missing link between low handgrip strength and increased cardiovascular morbidity and mortality. Causality and direction of causality remain to be determined.
format	article
author	Maximilian König Nikolaus Buchmann Ute Seeland Dominik Spira Elisabeth Steinhagen-Thiessen Ilja Demuth
author_facet	Maximilian König Nikolaus Buchmann Ute Seeland Dominik Spira Elisabeth Steinhagen-Thiessen Ilja Demuth
author_sort	Maximilian König
title	Low muscle strength and increased arterial stiffness go hand in hand
title_short	Low muscle strength and increased arterial stiffness go hand in hand
title_full	Low muscle strength and increased arterial stiffness go hand in hand
title_fullStr	Low muscle strength and increased arterial stiffness go hand in hand
title_full_unstemmed	Low muscle strength and increased arterial stiffness go hand in hand
title_sort	low muscle strength and increased arterial stiffness go hand in hand
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/128a240ab93b4173a781fc94f1279241
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Low muscle strength and increased arterial stiffness go hand in hand

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