Blood meal acquisition enhances arbovirus replication in mosquitoes through activation of the GABAergic system

Transmission of many human viruses depends on replication in their mosquito vectors. Here, Zhu et al. show that glutamic acid digested from the blood meal activates GABA signaling, resulting in suppression of antiviral innate immunity and increased virus replication in mosquitoes.

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Autores principales:	Yibin Zhu, Rudian Zhang, Bei Zhang, Tongyan Zhao, Penghua Wang, Guodong Liang, Gong Cheng
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/128f4612301e48169d93e54d0e4a065f
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spelling	oai:doaj.org-article:128f4612301e48169d93e54d0e4a065f2021-12-02T17:06:29ZBlood meal acquisition enhances arbovirus replication in mosquitoes through activation of the GABAergic system10.1038/s41467-017-01244-62041-1723https://doaj.org/article/128f4612301e48169d93e54d0e4a065f2017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01244-6https://doaj.org/toc/2041-1723Transmission of many human viruses depends on replication in their mosquito vectors. Here, Zhu et al. show that glutamic acid digested from the blood meal activates GABA signaling, resulting in suppression of antiviral innate immunity and increased virus replication in mosquitoes.Yibin ZhuRudian ZhangBei ZhangTongyan ZhaoPenghua WangGuodong LiangGong ChengNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yibin Zhu Rudian Zhang Bei Zhang Tongyan Zhao Penghua Wang Guodong Liang Gong Cheng Blood meal acquisition enhances arbovirus replication in mosquitoes through activation of the GABAergic system
description	Transmission of many human viruses depends on replication in their mosquito vectors. Here, Zhu et al. show that glutamic acid digested from the blood meal activates GABA signaling, resulting in suppression of antiviral innate immunity and increased virus replication in mosquitoes.
format	article
author	Yibin Zhu Rudian Zhang Bei Zhang Tongyan Zhao Penghua Wang Guodong Liang Gong Cheng
author_facet	Yibin Zhu Rudian Zhang Bei Zhang Tongyan Zhao Penghua Wang Guodong Liang Gong Cheng
author_sort	Yibin Zhu
title	Blood meal acquisition enhances arbovirus replication in mosquitoes through activation of the GABAergic system
title_short	Blood meal acquisition enhances arbovirus replication in mosquitoes through activation of the GABAergic system
title_full	Blood meal acquisition enhances arbovirus replication in mosquitoes through activation of the GABAergic system
title_fullStr	Blood meal acquisition enhances arbovirus replication in mosquitoes through activation of the GABAergic system
title_full_unstemmed	Blood meal acquisition enhances arbovirus replication in mosquitoes through activation of the GABAergic system
title_sort	blood meal acquisition enhances arbovirus replication in mosquitoes through activation of the gabaergic system
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/128f4612301e48169d93e54d0e4a065f
work_keys_str_mv	AT yibinzhu bloodmealacquisitionenhancesarbovirusreplicationinmosquitoesthroughactivationofthegabaergicsystem AT rudianzhang bloodmealacquisitionenhancesarbovirusreplicationinmosquitoesthroughactivationofthegabaergicsystem AT beizhang bloodmealacquisitionenhancesarbovirusreplicationinmosquitoesthroughactivationofthegabaergicsystem AT tongyanzhao bloodmealacquisitionenhancesarbovirusreplicationinmosquitoesthroughactivationofthegabaergicsystem AT penghuawang bloodmealacquisitionenhancesarbovirusreplicationinmosquitoesthroughactivationofthegabaergicsystem AT guodongliang bloodmealacquisitionenhancesarbovirusreplicationinmosquitoesthroughactivationofthegabaergicsystem AT gongcheng bloodmealacquisitionenhancesarbovirusreplicationinmosquitoesthroughactivationofthegabaergicsystem
_version_	1718381598741626880

Blood meal acquisition enhances arbovirus replication in mosquitoes through activation of the GABAergic system

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