Crystal structure of human Mediator subunit MED23

Crystal structure of human Mediator subunit MED23

Mediator is a large multi-subunits complex essential to the regulation of transcription by RNA pol II. Here the authors report the crystal structure of MED23—one of the largest subunits of the complex together with MED1 and MED14—revealing a complex architecture and filling an important gap in the s...

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Autores principales: Didier Monté, Bernard Clantin, Frédérique Dewitte, Zoé Lens, Prakash Rucktooa, Els Pardon, Jan Steyaert, Alexis Verger, Vincent Villeret
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/128fb504de7f40d08b3482fbcb664f49
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spelling oai:doaj.org-article:128fb504de7f40d08b3482fbcb664f492021-12-02T14:40:02ZCrystal structure of human Mediator subunit MED2310.1038/s41467-018-05967-y2041-1723https://doaj.org/article/128fb504de7f40d08b3482fbcb664f492018-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05967-yhttps://doaj.org/toc/2041-1723Mediator is a large multi-subunits complex essential to the regulation of transcription by RNA pol II. Here the authors report the crystal structure of MED23—one of the largest subunits of the complex together with MED1 and MED14—revealing a complex architecture and filling an important gap in the structural characterization of Mediator.Didier MontéBernard ClantinFrédérique DewitteZoé LensPrakash RucktooaEls PardonJan SteyaertAlexis VergerVincent VilleretNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-7 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Didier Monté
Bernard Clantin
Frédérique Dewitte
Zoé Lens
Prakash Rucktooa
Els Pardon
Jan Steyaert
Alexis Verger
Vincent Villeret
Crystal structure of human Mediator subunit MED23
description Mediator is a large multi-subunits complex essential to the regulation of transcription by RNA pol II. Here the authors report the crystal structure of MED23—one of the largest subunits of the complex together with MED1 and MED14—revealing a complex architecture and filling an important gap in the structural characterization of Mediator.
format article
author Didier Monté
Bernard Clantin
Frédérique Dewitte
Zoé Lens
Prakash Rucktooa
Els Pardon
Jan Steyaert
Alexis Verger
Vincent Villeret
author_facet Didier Monté
Bernard Clantin
Frédérique Dewitte
Zoé Lens
Prakash Rucktooa
Els Pardon
Jan Steyaert
Alexis Verger
Vincent Villeret
author_sort Didier Monté
title Crystal structure of human Mediator subunit MED23
title_short Crystal structure of human Mediator subunit MED23
title_full Crystal structure of human Mediator subunit MED23
title_fullStr Crystal structure of human Mediator subunit MED23
title_full_unstemmed Crystal structure of human Mediator subunit MED23
title_sort crystal structure of human mediator subunit med23
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/128fb504de7f40d08b3482fbcb664f49
work_keys_str_mv AT didiermonte crystalstructureofhumanmediatorsubunitmed23
AT bernardclantin crystalstructureofhumanmediatorsubunitmed23
AT frederiquedewitte crystalstructureofhumanmediatorsubunitmed23
AT zoelens crystalstructureofhumanmediatorsubunitmed23
AT prakashrucktooa crystalstructureofhumanmediatorsubunitmed23
AT elspardon crystalstructureofhumanmediatorsubunitmed23
AT jansteyaert crystalstructureofhumanmediatorsubunitmed23
AT alexisverger crystalstructureofhumanmediatorsubunitmed23
AT vincentvilleret crystalstructureofhumanmediatorsubunitmed23
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