Clinical characteristics of patients with benign nonlesional temporal lobe epilepsy

Jiyeon Kim,1 Seong Hoon Kim,2 Sung Chul Lim,2 Woojun Kim,2 Young-Min Shon3 1Department of Neurology, Korea University Ansan Hospital, College of Medicine, Korea University, Ansan, 2Department of Neurology, Catholic Neuroscience Institute, College of Medicine, The Catholic University of Korea, Seoch...

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Autores principales:	Kim J, Kim SH, Lim SC, Kim W, Shon YM
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	Epilepsy nonlesional temporal lobe epilepsy benign TLE prognostic factor Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/1290399bcd4145e0bbebc88aad2af3d3
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spelling	oai:doaj.org-article:1290399bcd4145e0bbebc88aad2af3d32021-12-02T07:09:54ZClinical characteristics of patients with benign nonlesional temporal lobe epilepsy1178-2021https://doaj.org/article/1290399bcd4145e0bbebc88aad2af3d32016-07-01T00:00:00Zhttps://www.dovepress.com/clinical-characteristics-of-patients-with-benign-nonlesional-temporal--peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Jiyeon Kim,1 Seong Hoon Kim,2 Sung Chul Lim,2 Woojun Kim,2 Young-Min Shon3 1Department of Neurology, Korea University Ansan Hospital, College of Medicine, Korea University, Ansan, 2Department of Neurology, Catholic Neuroscience Institute, College of Medicine, The Catholic University of Korea, Seocho-gu, 3Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea Purpose: To evaluate the evolution of nonlesional temporal lobe epilepsy (TLE-NL) in patients treated exclusively with antiepileptic drugs and to elucidate clinical phenotypes related to the prognosis of these patients.Methods: Clinical, radiological, and electroencephalographic (EEG) findings in 84 patients with TLE-NL were reviewed. A good response group (GRG) and a poor response group (PRG) were defined if the duration of their seizure-free period was >1 year, or <1 year, respectively.Results: There were 46 (54.8%) patients in the GRG and 38 (45.2%) patients in the PRG. The number of antiepileptic drugs administered was significantly lower in the GRG than that in the PRG (1.3±0.8 vs 2.8±1.0, respectively; P<0.05). The GRG had a significantly older age of onset than the PRG and a lower occurrence of initial precipitating events, such as febrile seizures, central nervous system infection, and head trauma (P<0.05). The prevalence of EEG abnormality, presence of aura, generalized seizures, and automatism was less frequently observed in the GRG (P<0.05). Multivariate analysis showed that the presence of automatism and initial precipitating events were significantly associated with a poor prognosis (P<0.05).Conclusion: In contrast to the commonly assumed intractability of TLE, we found that more than 54% of patients with TLE-NL achieved a long seizure-free period. Older age at onset of TLE-NL was associated with a better prognosis. However, the presence of automatism and initial precipitating events were related to a poor prognosis. Future prospective studies with a much larger population are warranted. Keywords: epilepsy, benign temporal lobe epilepsy, nonlesional temporal lobe epilepsyKim JKim SHLim SCKim WShon YMDove Medical PressarticleEpilepsynonlesional temporal lobe epilepsybenign TLEprognostic factorNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2016, Iss Issue 1, Pp 1887-1891 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Epilepsy nonlesional temporal lobe epilepsy benign TLE prognostic factor Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Epilepsy nonlesional temporal lobe epilepsy benign TLE prognostic factor Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Kim J Kim SH Lim SC Kim W Shon YM Clinical characteristics of patients with benign nonlesional temporal lobe epilepsy
description	Jiyeon Kim,1 Seong Hoon Kim,2 Sung Chul Lim,2 Woojun Kim,2 Young-Min Shon3 1Department of Neurology, Korea University Ansan Hospital, College of Medicine, Korea University, Ansan, 2Department of Neurology, Catholic Neuroscience Institute, College of Medicine, The Catholic University of Korea, Seocho-gu, 3Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea Purpose: To evaluate the evolution of nonlesional temporal lobe epilepsy (TLE-NL) in patients treated exclusively with antiepileptic drugs and to elucidate clinical phenotypes related to the prognosis of these patients.Methods: Clinical, radiological, and electroencephalographic (EEG) findings in 84 patients with TLE-NL were reviewed. A good response group (GRG) and a poor response group (PRG) were defined if the duration of their seizure-free period was >1 year, or <1 year, respectively.Results: There were 46 (54.8%) patients in the GRG and 38 (45.2%) patients in the PRG. The number of antiepileptic drugs administered was significantly lower in the GRG than that in the PRG (1.3±0.8 vs 2.8±1.0, respectively; P<0.05). The GRG had a significantly older age of onset than the PRG and a lower occurrence of initial precipitating events, such as febrile seizures, central nervous system infection, and head trauma (P<0.05). The prevalence of EEG abnormality, presence of aura, generalized seizures, and automatism was less frequently observed in the GRG (P<0.05). Multivariate analysis showed that the presence of automatism and initial precipitating events were significantly associated with a poor prognosis (P<0.05).Conclusion: In contrast to the commonly assumed intractability of TLE, we found that more than 54% of patients with TLE-NL achieved a long seizure-free period. Older age at onset of TLE-NL was associated with a better prognosis. However, the presence of automatism and initial precipitating events were related to a poor prognosis. Future prospective studies with a much larger population are warranted. Keywords: epilepsy, benign temporal lobe epilepsy, nonlesional temporal lobe epilepsy
format	article
author	Kim J Kim SH Lim SC Kim W Shon YM
author_facet	Kim J Kim SH Lim SC Kim W Shon YM
author_sort	Kim J
title	Clinical characteristics of patients with benign nonlesional temporal lobe epilepsy
title_short	Clinical characteristics of patients with benign nonlesional temporal lobe epilepsy
title_full	Clinical characteristics of patients with benign nonlesional temporal lobe epilepsy
title_fullStr	Clinical characteristics of patients with benign nonlesional temporal lobe epilepsy
title_full_unstemmed	Clinical characteristics of patients with benign nonlesional temporal lobe epilepsy
title_sort	clinical characteristics of patients with benign nonlesional temporal lobe epilepsy
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/1290399bcd4145e0bbebc88aad2af3d3
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_version_	1718399557221482496

Clinical characteristics of patients with benign nonlesional temporal lobe epilepsy

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