Staphylococcus aureus produces pain through pore-forming toxins and neuronal TRPV1 that is silenced by QX-314

Bacterial infection can cause pain but the underlying mechanism is unclear. This study shows pain induced in mice by methicillin-resistant Staphylococcus aureus infection is mediated by bacterial pore-forming toxins, and a sodium channel blocker QX-314 can alleviate infection-associated pain.

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Autores principales:	Kimbria J. Blake, Pankaj Baral, Tiphaine Voisin, Ashira Lubkin, Felipe Almeida Pinho-Ribeiro, Kelsey L. Adams, David P. Roberson, Yuxin C. Ma, Michael Otto, Clifford J. Woolf, Victor J. Torres, Isaac M. Chiu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/12940086f7914bb98b02fd6144e957e5
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:12940086f7914bb98b02fd6144e957e52021-12-02T16:49:21ZStaphylococcus aureus produces pain through pore-forming toxins and neuronal TRPV1 that is silenced by QX-31410.1038/s41467-017-02448-62041-1723https://doaj.org/article/12940086f7914bb98b02fd6144e957e52018-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02448-6https://doaj.org/toc/2041-1723Bacterial infection can cause pain but the underlying mechanism is unclear. This study shows pain induced in mice by methicillin-resistant Staphylococcus aureus infection is mediated by bacterial pore-forming toxins, and a sodium channel blocker QX-314 can alleviate infection-associated pain.Kimbria J. BlakePankaj BaralTiphaine VoisinAshira LubkinFelipe Almeida Pinho-RibeiroKelsey L. AdamsDavid P. RobersonYuxin C. MaMichael OttoClifford J. WoolfVictor J. TorresIsaac M. ChiuNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kimbria J. Blake Pankaj Baral Tiphaine Voisin Ashira Lubkin Felipe Almeida Pinho-Ribeiro Kelsey L. Adams David P. Roberson Yuxin C. Ma Michael Otto Clifford J. Woolf Victor J. Torres Isaac M. Chiu Staphylococcus aureus produces pain through pore-forming toxins and neuronal TRPV1 that is silenced by QX-314
description	Bacterial infection can cause pain but the underlying mechanism is unclear. This study shows pain induced in mice by methicillin-resistant Staphylococcus aureus infection is mediated by bacterial pore-forming toxins, and a sodium channel blocker QX-314 can alleviate infection-associated pain.
format	article
author	Kimbria J. Blake Pankaj Baral Tiphaine Voisin Ashira Lubkin Felipe Almeida Pinho-Ribeiro Kelsey L. Adams David P. Roberson Yuxin C. Ma Michael Otto Clifford J. Woolf Victor J. Torres Isaac M. Chiu
author_facet	Kimbria J. Blake Pankaj Baral Tiphaine Voisin Ashira Lubkin Felipe Almeida Pinho-Ribeiro Kelsey L. Adams David P. Roberson Yuxin C. Ma Michael Otto Clifford J. Woolf Victor J. Torres Isaac M. Chiu
author_sort	Kimbria J. Blake
title	Staphylococcus aureus produces pain through pore-forming toxins and neuronal TRPV1 that is silenced by QX-314
title_short	Staphylococcus aureus produces pain through pore-forming toxins and neuronal TRPV1 that is silenced by QX-314
title_full	Staphylococcus aureus produces pain through pore-forming toxins and neuronal TRPV1 that is silenced by QX-314
title_fullStr	Staphylococcus aureus produces pain through pore-forming toxins and neuronal TRPV1 that is silenced by QX-314
title_full_unstemmed	Staphylococcus aureus produces pain through pore-forming toxins and neuronal TRPV1 that is silenced by QX-314
title_sort	staphylococcus aureus produces pain through pore-forming toxins and neuronal trpv1 that is silenced by qx-314
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/12940086f7914bb98b02fd6144e957e5
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Staphylococcus aureus produces pain through pore-forming toxins and neuronal TRPV1 that is silenced by QX-314

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