S-nitrosylated and non-nitrosylated COX2 have differential expression and distinct subcellular localization in normal and breast cancer tissue

S-nitrosylated and non-nitrosylated COX2 have differential expression and distinct subcellular localization in normal and breast cancer tissue

Abstract Immunohistochemical (IHC) staining in breast cancer shows both gain and loss of COX2 expression with disease risk and progression. We investigated four common COX2 antibody clones and found high specificity for purified human COX2 for three clones; however, recognition of COX2 in cell lysat...

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Autores principales: Sonali Jindal, Nathan D. Pennock, Alex Klug, Jayasri Narasimhan, Andrea Calhoun, Michelle R. Roberts, Rulla M. Tamimi, A. Heather Eliassen, Sheila Weinmann, Virginia F. Borges, Pepper Schedin
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
Materias:
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
RC254-282
Acceso en línea:https://doaj.org/article/129419c4a8544d358cac1ef1e1e746bd
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