ROLE OF IL-6 IN EXPERIMENTAL ARTHRITIS CAUSED BY TRANSFER OF ARTHRITOGENIC ANTIBODIES

Interleukin-6 (IL-6) exerts important functions on immune regulation. In case of high expression, IL-6 may promote autoimmune disorders, e.g., arthritis. Systemic IL-6 blockers based on monoclonal antibodies against IL-6, or its specific receptor subunit, are already used in clinical settings, addin...

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Autores principales:	M. S. Drutskaya, E. A. Gorshkova, A. S. Zhdanova, K.-S. Atretkhany, V. S. Gogoleva, R. V. Zvartsev, A. A. Kruglov, S. A. Nedospasov
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2016
Materias:	interleukin-6 experimental arthritis anti-collagen antibodies transfer neutralizing antibodies tnf Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/12943e1321844d0c821fce0d89537cbd
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spelling	oai:doaj.org-article:12943e1321844d0c821fce0d89537cbd2021-11-18T08:03:45ZROLE OF IL-6 IN EXPERIMENTAL ARTHRITIS CAUSED BY TRANSFER OF ARTHRITOGENIC ANTIBODIES1563-06252313-741X10.15789/1563-0625-2016-6-569-574https://doaj.org/article/12943e1321844d0c821fce0d89537cbd2016-12-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/1139https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XInterleukin-6 (IL-6) exerts important functions on immune regulation. In case of high expression, IL-6 may promote autoimmune disorders, e.g., arthritis. Systemic IL-6 blockers based on monoclonal antibodies against IL-6, or its specific receptor subunit, are already used in clinical settings, adding to a range of known biological drugs, such as, TNF blockers. Rheumatic disorders and their experimental therapy are reproducible in mice. This study revealed systemically increased levels of IL-6 in developing arthritis caused by transfer of pathogenic antibodies, as well as the effects of IL-6 neutralization by monoclonal antibodies against murine IL-6. Our results suggest a pathogenic role of the two cytokines, TNF and IL-6, in experimental arthritis induced by passive transfer of anti-collagen antibodies.M. S. DrutskayaE. A. GorshkovaA. S. ZhdanovaK.-S. AtretkhanyV. S. GogolevaR. V. ZvartsevA. A. KruglovS. A. NedospasovSPb RAACIarticleinterleukin-6experimental arthritisanti-collagen antibodies transferneutralizing antibodiestnfImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 18, Iss 6, Pp 569-574 (2016)
institution	DOAJ
collection	DOAJ
language	RU
topic	interleukin-6 experimental arthritis anti-collagen antibodies transfer neutralizing antibodies tnf Immunologic diseases. Allergy RC581-607
spellingShingle	interleukin-6 experimental arthritis anti-collagen antibodies transfer neutralizing antibodies tnf Immunologic diseases. Allergy RC581-607 M. S. Drutskaya E. A. Gorshkova A. S. Zhdanova K.-S. Atretkhany V. S. Gogoleva R. V. Zvartsev A. A. Kruglov S. A. Nedospasov ROLE OF IL-6 IN EXPERIMENTAL ARTHRITIS CAUSED BY TRANSFER OF ARTHRITOGENIC ANTIBODIES
description	Interleukin-6 (IL-6) exerts important functions on immune regulation. In case of high expression, IL-6 may promote autoimmune disorders, e.g., arthritis. Systemic IL-6 blockers based on monoclonal antibodies against IL-6, or its specific receptor subunit, are already used in clinical settings, adding to a range of known biological drugs, such as, TNF blockers. Rheumatic disorders and their experimental therapy are reproducible in mice. This study revealed systemically increased levels of IL-6 in developing arthritis caused by transfer of pathogenic antibodies, as well as the effects of IL-6 neutralization by monoclonal antibodies against murine IL-6. Our results suggest a pathogenic role of the two cytokines, TNF and IL-6, in experimental arthritis induced by passive transfer of anti-collagen antibodies.
format	article
author	M. S. Drutskaya E. A. Gorshkova A. S. Zhdanova K.-S. Atretkhany V. S. Gogoleva R. V. Zvartsev A. A. Kruglov S. A. Nedospasov
author_facet	M. S. Drutskaya E. A. Gorshkova A. S. Zhdanova K.-S. Atretkhany V. S. Gogoleva R. V. Zvartsev A. A. Kruglov S. A. Nedospasov
author_sort	M. S. Drutskaya
title	ROLE OF IL-6 IN EXPERIMENTAL ARTHRITIS CAUSED BY TRANSFER OF ARTHRITOGENIC ANTIBODIES
title_short	ROLE OF IL-6 IN EXPERIMENTAL ARTHRITIS CAUSED BY TRANSFER OF ARTHRITOGENIC ANTIBODIES
title_full	ROLE OF IL-6 IN EXPERIMENTAL ARTHRITIS CAUSED BY TRANSFER OF ARTHRITOGENIC ANTIBODIES
title_fullStr	ROLE OF IL-6 IN EXPERIMENTAL ARTHRITIS CAUSED BY TRANSFER OF ARTHRITOGENIC ANTIBODIES
title_full_unstemmed	ROLE OF IL-6 IN EXPERIMENTAL ARTHRITIS CAUSED BY TRANSFER OF ARTHRITOGENIC ANTIBODIES
title_sort	role of il-6 in experimental arthritis caused by transfer of arthritogenic antibodies
publisher	SPb RAACI
publishDate	2016
url	https://doaj.org/article/12943e1321844d0c821fce0d89537cbd
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ROLE OF IL-6 IN EXPERIMENTAL ARTHRITIS CAUSED BY TRANSFER OF ARTHRITOGENIC ANTIBODIES

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