Polyphenols-rich extracts from walnut green husk prevent non-alcoholic fatty liver disease, vascular endothelial dysfunction and colon tissue damage in rats induced by high-fat diet

This study is aims to evaluate the beneficial effects of polyphenols-rich extracts from walnut green husk (WGHP) on the prevention of obesity, nonalcoholic fatty liver disease (NAFLD), vascular endothelial dysfunction and colon tissue damage in rats fed high fat diet for 8 weeks. HPLC analysis showe...

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Autores principales:	Guoliang Wang, Qiqi Han, Xinpeng Yan, Luoluo Feng, Yani Zhang, Runguang Zhang, Youlin Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Walnut green husk Polyphenol Obesity Nonalcoholic fatty liver disease Gut microbiota Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/1294d70bf1a2474d9a626c8354581baa
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spelling	oai:doaj.org-article:1294d70bf1a2474d9a626c8354581baa2021-11-12T04:29:05ZPolyphenols-rich extracts from walnut green husk prevent non-alcoholic fatty liver disease, vascular endothelial dysfunction and colon tissue damage in rats induced by high-fat diet1756-464610.1016/j.jff.2021.104853https://doaj.org/article/1294d70bf1a2474d9a626c8354581baa2021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S1756464621005028https://doaj.org/toc/1756-4646This study is aims to evaluate the beneficial effects of polyphenols-rich extracts from walnut green husk (WGHP) on the prevention of obesity, nonalcoholic fatty liver disease (NAFLD), vascular endothelial dysfunction and colon tissue damage in rats fed high fat diet for 8 weeks. HPLC analysis showed that epicatechin, rutin and caffeic acid are the main components of WGHP. Administration of WGHP to HF-fed rats effectively prevented abnormal body weight gain, lipid metabolism disorder, oxidative stress and inflammation. Biochemical analysis and histopathological observation consistently confirmed the protective effects of WGHP on NAFLD, vascular endothelial dysfunction and colon tissue damage in rats caused by HF. In addition, 16S RNA sequencing results showed that WGHP reduced the Firmicutes/Bacteroidetes ratio in HF-fed rats and reversed the relative abundance of Ruminococcaceae-UCG-014 and Fusicatenibacter. These results suggest that WGHP may serve as a nutritional agent for protecting liver, cardiovascular and colon tissue in HF-fed rats.Guoliang WangQiqi HanXinpeng YanLuoluo FengYani ZhangRunguang ZhangYoulin ZhangElsevierarticleWalnut green huskPolyphenolObesityNonalcoholic fatty liver diseaseGut microbiotaNutrition. Foods and food supplyTX341-641ENJournal of Functional Foods, Vol 87, Iss , Pp 104853- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Walnut green husk Polyphenol Obesity Nonalcoholic fatty liver disease Gut microbiota Nutrition. Foods and food supply TX341-641
spellingShingle	Walnut green husk Polyphenol Obesity Nonalcoholic fatty liver disease Gut microbiota Nutrition. Foods and food supply TX341-641 Guoliang Wang Qiqi Han Xinpeng Yan Luoluo Feng Yani Zhang Runguang Zhang Youlin Zhang Polyphenols-rich extracts from walnut green husk prevent non-alcoholic fatty liver disease, vascular endothelial dysfunction and colon tissue damage in rats induced by high-fat diet
description	This study is aims to evaluate the beneficial effects of polyphenols-rich extracts from walnut green husk (WGHP) on the prevention of obesity, nonalcoholic fatty liver disease (NAFLD), vascular endothelial dysfunction and colon tissue damage in rats fed high fat diet for 8 weeks. HPLC analysis showed that epicatechin, rutin and caffeic acid are the main components of WGHP. Administration of WGHP to HF-fed rats effectively prevented abnormal body weight gain, lipid metabolism disorder, oxidative stress and inflammation. Biochemical analysis and histopathological observation consistently confirmed the protective effects of WGHP on NAFLD, vascular endothelial dysfunction and colon tissue damage in rats caused by HF. In addition, 16S RNA sequencing results showed that WGHP reduced the Firmicutes/Bacteroidetes ratio in HF-fed rats and reversed the relative abundance of Ruminococcaceae-UCG-014 and Fusicatenibacter. These results suggest that WGHP may serve as a nutritional agent for protecting liver, cardiovascular and colon tissue in HF-fed rats.
format	article
author	Guoliang Wang Qiqi Han Xinpeng Yan Luoluo Feng Yani Zhang Runguang Zhang Youlin Zhang
author_facet	Guoliang Wang Qiqi Han Xinpeng Yan Luoluo Feng Yani Zhang Runguang Zhang Youlin Zhang
author_sort	Guoliang Wang
title	Polyphenols-rich extracts from walnut green husk prevent non-alcoholic fatty liver disease, vascular endothelial dysfunction and colon tissue damage in rats induced by high-fat diet
title_short	Polyphenols-rich extracts from walnut green husk prevent non-alcoholic fatty liver disease, vascular endothelial dysfunction and colon tissue damage in rats induced by high-fat diet
title_full	Polyphenols-rich extracts from walnut green husk prevent non-alcoholic fatty liver disease, vascular endothelial dysfunction and colon tissue damage in rats induced by high-fat diet
title_fullStr	Polyphenols-rich extracts from walnut green husk prevent non-alcoholic fatty liver disease, vascular endothelial dysfunction and colon tissue damage in rats induced by high-fat diet
title_full_unstemmed	Polyphenols-rich extracts from walnut green husk prevent non-alcoholic fatty liver disease, vascular endothelial dysfunction and colon tissue damage in rats induced by high-fat diet
title_sort	polyphenols-rich extracts from walnut green husk prevent non-alcoholic fatty liver disease, vascular endothelial dysfunction and colon tissue damage in rats induced by high-fat diet
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/1294d70bf1a2474d9a626c8354581baa
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Polyphenols-rich extracts from walnut green husk prevent non-alcoholic fatty liver disease, vascular endothelial dysfunction and colon tissue damage in rats induced by high-fat diet

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