Thalamic Bursts Down-regulate Cortical Theta and Nociceptive Behavior

Abstract We tested the relation between pain behavior, theta (4–8 Hz) oscillations in somatosensory cortex and burst firing in thalamic neurons in vivo. Optically-induced thalamic bursts attenuated cortical theta and mechanical allodynia. It is proposed that thalamic bursts are an adaptive response...

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Autores principales:	Brian W. LeBlanc, Brent Cross, Kelsey A. Smith, Catherine Roach, Jimmy Xia, Yu-Chieh Chao, Joshua Levitt, Suguru Koyama, Christopher I. Moore, Carl Y. Saab
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1294ec178cf74cba946d2b0729643c9a
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spelling	oai:doaj.org-article:1294ec178cf74cba946d2b0729643c9a2021-12-02T11:53:10ZThalamic Bursts Down-regulate Cortical Theta and Nociceptive Behavior10.1038/s41598-017-02753-62045-2322https://doaj.org/article/1294ec178cf74cba946d2b0729643c9a2017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-02753-6https://doaj.org/toc/2045-2322Abstract We tested the relation between pain behavior, theta (4–8 Hz) oscillations in somatosensory cortex and burst firing in thalamic neurons in vivo. Optically-induced thalamic bursts attenuated cortical theta and mechanical allodynia. It is proposed that thalamic bursts are an adaptive response to pain that de-synchronizes cortical theta and decreases sensory salience.Brian W. LeBlancBrent CrossKelsey A. SmithCatherine RoachJimmy XiaYu-Chieh ChaoJoshua LevittSuguru KoyamaChristopher I. MooreCarl Y. SaabNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Brian W. LeBlanc Brent Cross Kelsey A. Smith Catherine Roach Jimmy Xia Yu-Chieh Chao Joshua Levitt Suguru Koyama Christopher I. Moore Carl Y. Saab Thalamic Bursts Down-regulate Cortical Theta and Nociceptive Behavior
description	Abstract We tested the relation between pain behavior, theta (4–8 Hz) oscillations in somatosensory cortex and burst firing in thalamic neurons in vivo. Optically-induced thalamic bursts attenuated cortical theta and mechanical allodynia. It is proposed that thalamic bursts are an adaptive response to pain that de-synchronizes cortical theta and decreases sensory salience.
format	article
author	Brian W. LeBlanc Brent Cross Kelsey A. Smith Catherine Roach Jimmy Xia Yu-Chieh Chao Joshua Levitt Suguru Koyama Christopher I. Moore Carl Y. Saab
author_facet	Brian W. LeBlanc Brent Cross Kelsey A. Smith Catherine Roach Jimmy Xia Yu-Chieh Chao Joshua Levitt Suguru Koyama Christopher I. Moore Carl Y. Saab
author_sort	Brian W. LeBlanc
title	Thalamic Bursts Down-regulate Cortical Theta and Nociceptive Behavior
title_short	Thalamic Bursts Down-regulate Cortical Theta and Nociceptive Behavior
title_full	Thalamic Bursts Down-regulate Cortical Theta and Nociceptive Behavior
title_fullStr	Thalamic Bursts Down-regulate Cortical Theta and Nociceptive Behavior
title_full_unstemmed	Thalamic Bursts Down-regulate Cortical Theta and Nociceptive Behavior
title_sort	thalamic bursts down-regulate cortical theta and nociceptive behavior
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/1294ec178cf74cba946d2b0729643c9a
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Thalamic Bursts Down-regulate Cortical Theta and Nociceptive Behavior

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