The Effect of Bioactive Polyphenols from <i>Anacardium occidentale</i> Linn. Leaves on α-Amylase and Dipeptidyl Peptidase IV Activities

Anacardium occidentale Linn. (A. occidentale L.) leaves possess bioactive polyphenols which are associated with antidiabetic potency for the management of type 2 diabetes mellitus (T2DM). In this study, free, soluble ester, and insoluble-bound phenolic fractions from young and mature leaves of A. oc...

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Autores principales:	Nur Imanina Abdullah Thaidi, Hanapi Mat Jusoh, Ahmad Badruddin Ghazali, Deny Susanti, Normah Haron
Formato:	article
Lenguaje:	EN
Publicado:	Department of Chemistry, Universitas Gadjah Mada 2020
Materias:	anarcadium occidentale linn dipeptidyl peptidase iv α-amylase inhibitor Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/129677c3ca7043049009bdefe60faa25
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spelling	oai:doaj.org-article:129677c3ca7043049009bdefe60faa252021-12-02T12:06:18ZThe Effect of Bioactive Polyphenols from <i>Anacardium occidentale</i> Linn. Leaves on α-Amylase and Dipeptidyl Peptidase IV Activities1411-94202460-157810.22146/ijc.44807https://doaj.org/article/129677c3ca7043049009bdefe60faa252020-07-01T00:00:00Zhttps://jurnal.ugm.ac.id/ijc/article/view/44807https://doaj.org/toc/1411-9420https://doaj.org/toc/2460-1578Anacardium occidentale Linn. (A. occidentale L.) leaves possess bioactive polyphenols which are associated with antidiabetic potency for the management of type 2 diabetes mellitus (T2DM). In this study, free, soluble ester, and insoluble-bound phenolic fractions from young and mature leaves of A. occidentale L. were extracted. Subsequently, all fractions were investigated for their inhibitory effect on α-amylase and dipeptidyl peptidase IV (DPPIV) activities. Both free (72.45 ± 3.6%) and soluble ester (83.40 ± 4.7%) phenolic fractions in the mature leaves extracts had significantly demonstrated greater α-amylase inhibitors than the young leaves. Likewise, soluble ester (4.09 ± 0.34 µg/mL) and insoluble-bound (4.87 ± 0.32 µg/mL) phenolic fractions in the mature leaves extracts were significantly more effective in inhibiting DPPIV than the young leaves. As for fractions comparison, insoluble-bound derived from the young leaves extract was a more potent α-amylase inhibitor than free and soluble ester phenolic fractions (p < 0.0001). Besides, soluble ester and insoluble-bound phenolic fractions showed a stronger inhibitor of DPPIV than the free phenolic (p < 0.001), irrespective of the maturity of the leaves. In conclusion, this study showed that A. occidentale L. extracts possessed antidiabetic properties, which may potentially be used as an alternative treatment for T2DM management.Nur Imanina Abdullah ThaidiHanapi Mat JusohAhmad Badruddin GhazaliDeny SusantiNormah HaronDepartment of Chemistry, Universitas Gadjah Madaarticleanarcadium occidentale linndipeptidyl peptidase ivα-amylaseinhibitorChemistryQD1-999ENIndonesian Journal of Chemistry, Vol 20, Iss 5, Pp 1010-1017 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	anarcadium occidentale linn dipeptidyl peptidase iv α-amylase inhibitor Chemistry QD1-999
spellingShingle	anarcadium occidentale linn dipeptidyl peptidase iv α-amylase inhibitor Chemistry QD1-999 Nur Imanina Abdullah Thaidi Hanapi Mat Jusoh Ahmad Badruddin Ghazali Deny Susanti Normah Haron The Effect of Bioactive Polyphenols from <i>Anacardium occidentale</i> Linn. Leaves on α-Amylase and Dipeptidyl Peptidase IV Activities
description	Anacardium occidentale Linn. (A. occidentale L.) leaves possess bioactive polyphenols which are associated with antidiabetic potency for the management of type 2 diabetes mellitus (T2DM). In this study, free, soluble ester, and insoluble-bound phenolic fractions from young and mature leaves of A. occidentale L. were extracted. Subsequently, all fractions were investigated for their inhibitory effect on α-amylase and dipeptidyl peptidase IV (DPPIV) activities. Both free (72.45 ± 3.6%) and soluble ester (83.40 ± 4.7%) phenolic fractions in the mature leaves extracts had significantly demonstrated greater α-amylase inhibitors than the young leaves. Likewise, soluble ester (4.09 ± 0.34 µg/mL) and insoluble-bound (4.87 ± 0.32 µg/mL) phenolic fractions in the mature leaves extracts were significantly more effective in inhibiting DPPIV than the young leaves. As for fractions comparison, insoluble-bound derived from the young leaves extract was a more potent α-amylase inhibitor than free and soluble ester phenolic fractions (p < 0.0001). Besides, soluble ester and insoluble-bound phenolic fractions showed a stronger inhibitor of DPPIV than the free phenolic (p < 0.001), irrespective of the maturity of the leaves. In conclusion, this study showed that A. occidentale L. extracts possessed antidiabetic properties, which may potentially be used as an alternative treatment for T2DM management.
format	article
author	Nur Imanina Abdullah Thaidi Hanapi Mat Jusoh Ahmad Badruddin Ghazali Deny Susanti Normah Haron
author_facet	Nur Imanina Abdullah Thaidi Hanapi Mat Jusoh Ahmad Badruddin Ghazali Deny Susanti Normah Haron
author_sort	Nur Imanina Abdullah Thaidi
title	The Effect of Bioactive Polyphenols from <i>Anacardium occidentale</i> Linn. Leaves on α-Amylase and Dipeptidyl Peptidase IV Activities
title_short	The Effect of Bioactive Polyphenols from <i>Anacardium occidentale</i> Linn. Leaves on α-Amylase and Dipeptidyl Peptidase IV Activities
title_full	The Effect of Bioactive Polyphenols from <i>Anacardium occidentale</i> Linn. Leaves on α-Amylase and Dipeptidyl Peptidase IV Activities
title_fullStr	The Effect of Bioactive Polyphenols from <i>Anacardium occidentale</i> Linn. Leaves on α-Amylase and Dipeptidyl Peptidase IV Activities
title_full_unstemmed	The Effect of Bioactive Polyphenols from <i>Anacardium occidentale</i> Linn. Leaves on α-Amylase and Dipeptidyl Peptidase IV Activities
title_sort	effect of bioactive polyphenols from <i>anacardium occidentale</i> linn. leaves on α-amylase and dipeptidyl peptidase iv activities
publisher	Department of Chemistry, Universitas Gadjah Mada
publishDate	2020
url	https://doaj.org/article/129677c3ca7043049009bdefe60faa25
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The Effect of Bioactive Polyphenols from <i>Anacardium occidentale</i> Linn. Leaves on α-Amylase and Dipeptidyl Peptidase IV Activities

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