Identification of Autophagy-Related Prognostic Signature and Analysis of Immune Cell Infiltration in Low-Grade Gliomas

Autophagy plays an important role in cancer. Many studies have demonstrated that autophagy-related genes (ARGs) can act as a prognostic signature for some cancers, but little has been known in low-grade gliomas (LGG). In our study, we aimed to establish a prognostical model based on ARGs and find pr...

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Autores principales:	Qingli Quan, Xinxin Xiong, Shanyun Wu, Meixing Yu
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Medicine R
Acceso en línea:	https://doaj.org/article/12969df8b2fa4a01aced26772a92010d
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spelling	oai:doaj.org-article:12969df8b2fa4a01aced26772a92010d2021-11-22T01:09:29ZIdentification of Autophagy-Related Prognostic Signature and Analysis of Immune Cell Infiltration in Low-Grade Gliomas2314-614110.1155/2021/7918693https://doaj.org/article/12969df8b2fa4a01aced26772a92010d2021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/7918693https://doaj.org/toc/2314-6141Autophagy plays an important role in cancer. Many studies have demonstrated that autophagy-related genes (ARGs) can act as a prognostic signature for some cancers, but little has been known in low-grade gliomas (LGG). In our study, we aimed to establish a prognostical model based on ARGs and find prognostic risk-related key genes in LGG. In the present study, a prognostic signature was constructed based on a total of 8 ARGs (MAPK8IP1, EEF2, GRID2, BIRC5, DLC1, NAMPT, GRID1, and TP73). It was revealed that the higher the risk score, the worse was the prognosis. Time-dependent ROC analysis showed that the risk score could precisely predict the prognosis of LGG patients. Additionally, four key genes (TGFβ2, SERPING1, SERPINE1, and TIMP1) were identified and found significantly associated with OS of LGG patients. Besides, they were also discovered to be strongly related to six types of immune cells which infiltrated in LGG tumor. Taken together, the present study demonstrated the promising potential of the ARG risk score formula as an independent factor for LGG prediction. It also provided the autophagy-related signature of prognosis and potential therapeutic targets for the treatment of LGG.Qingli QuanXinxin XiongShanyun WuMeixing YuHindawi LimitedarticleMedicineRENBioMed Research International, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R
spellingShingle	Medicine R Qingli Quan Xinxin Xiong Shanyun Wu Meixing Yu Identification of Autophagy-Related Prognostic Signature and Analysis of Immune Cell Infiltration in Low-Grade Gliomas
description	Autophagy plays an important role in cancer. Many studies have demonstrated that autophagy-related genes (ARGs) can act as a prognostic signature for some cancers, but little has been known in low-grade gliomas (LGG). In our study, we aimed to establish a prognostical model based on ARGs and find prognostic risk-related key genes in LGG. In the present study, a prognostic signature was constructed based on a total of 8 ARGs (MAPK8IP1, EEF2, GRID2, BIRC5, DLC1, NAMPT, GRID1, and TP73). It was revealed that the higher the risk score, the worse was the prognosis. Time-dependent ROC analysis showed that the risk score could precisely predict the prognosis of LGG patients. Additionally, four key genes (TGFβ2, SERPING1, SERPINE1, and TIMP1) were identified and found significantly associated with OS of LGG patients. Besides, they were also discovered to be strongly related to six types of immune cells which infiltrated in LGG tumor. Taken together, the present study demonstrated the promising potential of the ARG risk score formula as an independent factor for LGG prediction. It also provided the autophagy-related signature of prognosis and potential therapeutic targets for the treatment of LGG.
format	article
author	Qingli Quan Xinxin Xiong Shanyun Wu Meixing Yu
author_facet	Qingli Quan Xinxin Xiong Shanyun Wu Meixing Yu
author_sort	Qingli Quan
title	Identification of Autophagy-Related Prognostic Signature and Analysis of Immune Cell Infiltration in Low-Grade Gliomas
title_short	Identification of Autophagy-Related Prognostic Signature and Analysis of Immune Cell Infiltration in Low-Grade Gliomas
title_full	Identification of Autophagy-Related Prognostic Signature and Analysis of Immune Cell Infiltration in Low-Grade Gliomas
title_fullStr	Identification of Autophagy-Related Prognostic Signature and Analysis of Immune Cell Infiltration in Low-Grade Gliomas
title_full_unstemmed	Identification of Autophagy-Related Prognostic Signature and Analysis of Immune Cell Infiltration in Low-Grade Gliomas
title_sort	identification of autophagy-related prognostic signature and analysis of immune cell infiltration in low-grade gliomas
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/12969df8b2fa4a01aced26772a92010d
work_keys_str_mv	AT qingliquan identificationofautophagyrelatedprognosticsignatureandanalysisofimmunecellinfiltrationinlowgradegliomas AT xinxinxiong identificationofautophagyrelatedprognosticsignatureandanalysisofimmunecellinfiltrationinlowgradegliomas AT shanyunwu identificationofautophagyrelatedprognosticsignatureandanalysisofimmunecellinfiltrationinlowgradegliomas AT meixingyu identificationofautophagyrelatedprognosticsignatureandanalysisofimmunecellinfiltrationinlowgradegliomas
_version_	1718418383157854208

Identification of Autophagy-Related Prognostic Signature and Analysis of Immune Cell Infiltration in Low-Grade Gliomas

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