Biomarkers of cellular aging during a controlled human malaria infection

Abstract Cellular aging is difficult to study in individuals with natural infection, given the diversity of symptom duration and clinical presentation, and the high interference of aging-related processes with host and environmental factors. To address this challenge, we took advantage of the contro...

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Autores principales:	Aurelie Miglar, Isaie J. Reuling, Xi Zen Yap, Anna Färnert, Robert W. Sauerwein, Muhammad Asghar
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/12981144613e4e3598aab3482a2aa476
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spelling	oai:doaj.org-article:12981144613e4e3598aab3482a2aa4762021-12-02T17:26:49ZBiomarkers of cellular aging during a controlled human malaria infection10.1038/s41598-021-97985-y2045-2322https://doaj.org/article/12981144613e4e3598aab3482a2aa4762021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-97985-yhttps://doaj.org/toc/2045-2322Abstract Cellular aging is difficult to study in individuals with natural infection, given the diversity of symptom duration and clinical presentation, and the high interference of aging-related processes with host and environmental factors. To address this challenge, we took advantage of the controlled human malaria infection (CHMI) model. This approach allowed us to characterize the relationship among cellular aging markers prior, during and post malaria pathophysiology in humans, controlling for infection dose, individual heterogeneity, previous exposure and co-infections. We demonstrate that already low levels of Plasmodium falciparum impact cellular aging by inducing high levels of inflammation and redox-imbalance; and that cellular senescence reversed after treatment and parasite clearance. This study provides insights into the complex relationship of telomere length, cellular senescence, telomerase expression and aging-related processes during a single malaria infection.Aurelie MiglarIsaie J. ReulingXi Zen YapAnna FärnertRobert W. SauerweinMuhammad AsgharNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Aurelie Miglar Isaie J. Reuling Xi Zen Yap Anna Färnert Robert W. Sauerwein Muhammad Asghar Biomarkers of cellular aging during a controlled human malaria infection
description	Abstract Cellular aging is difficult to study in individuals with natural infection, given the diversity of symptom duration and clinical presentation, and the high interference of aging-related processes with host and environmental factors. To address this challenge, we took advantage of the controlled human malaria infection (CHMI) model. This approach allowed us to characterize the relationship among cellular aging markers prior, during and post malaria pathophysiology in humans, controlling for infection dose, individual heterogeneity, previous exposure and co-infections. We demonstrate that already low levels of Plasmodium falciparum impact cellular aging by inducing high levels of inflammation and redox-imbalance; and that cellular senescence reversed after treatment and parasite clearance. This study provides insights into the complex relationship of telomere length, cellular senescence, telomerase expression and aging-related processes during a single malaria infection.
format	article
author	Aurelie Miglar Isaie J. Reuling Xi Zen Yap Anna Färnert Robert W. Sauerwein Muhammad Asghar
author_facet	Aurelie Miglar Isaie J. Reuling Xi Zen Yap Anna Färnert Robert W. Sauerwein Muhammad Asghar
author_sort	Aurelie Miglar
title	Biomarkers of cellular aging during a controlled human malaria infection
title_short	Biomarkers of cellular aging during a controlled human malaria infection
title_full	Biomarkers of cellular aging during a controlled human malaria infection
title_fullStr	Biomarkers of cellular aging during a controlled human malaria infection
title_full_unstemmed	Biomarkers of cellular aging during a controlled human malaria infection
title_sort	biomarkers of cellular aging during a controlled human malaria infection
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/12981144613e4e3598aab3482a2aa476
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Biomarkers of cellular aging during a controlled human malaria infection

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