Psoriasis and smoking: links and risks

Luigi Naldi1,2 1Department of Dermatology, Azienda Ospedaliera Papa Giovanni XXIII, Bergamo, Italy; 2Study Centre of the Italian Group for Epidemiologic Research in Dermatology (GISED), Bergamo, Italy Abstract: Smoking is a complex environmental exposure influenced by genetic, environmental, and soc...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autor principal:	Naldi L
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	smoking nicotine dependence risk psoriasis onset prognosis co-morbidities Dermatology RL1-803
Acceso en línea:	https://doaj.org/article/1298604327ab4c00beaaf727e22b61c9
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:1298604327ab4c00beaaf727e22b61c9
record_format	dspace
spelling	oai:doaj.org-article:1298604327ab4c00beaaf727e22b61c92021-12-02T00:55:48ZPsoriasis and smoking: links and risks2230-326Xhttps://doaj.org/article/1298604327ab4c00beaaf727e22b61c92016-05-01T00:00:00Zhttps://www.dovepress.com/psoriasis-and-smoking-links-and-risks-peer-reviewed-article-PTThttps://doaj.org/toc/2230-326XLuigi Naldi1,2 1Department of Dermatology, Azienda Ospedaliera Papa Giovanni XXIII, Bergamo, Italy; 2Study Centre of the Italian Group for Epidemiologic Research in Dermatology (GISED), Bergamo, Italy Abstract: Smoking is a complex environmental exposure influenced by genetic, environmental, and social factors. Nicotine is the principal alkaloid in tobacco that mediates the addicting effects of tobacco products. Tobacco is a mixture of more than 7,000 chemicals, and smoking is recognized as a risk factor for many diseases in humans, including cardiovascular and pulmonary disease and several cancers, and is the single most preventable cause of mortality worldwide. A number of inflammatory immune-related conditions have been associated with smoking, including psoriasis. Smoking affects the onset of psoriasis. In a pooled analysis of 25 case–control studies, the odds ratio of psoriasis among smokers was 1.78 (95% confidence interval [CI]: 1.53–2.06). A dose–effect relationship is also documented. In a pooled analysis of three cohort studies, the risk of incident psoriasis was 1.81 (95% CI: 1.38–2.36) in those who smoked 1–14 cigarettes per day, and 2.29 (95% CI: 1.74–3.01) in those who smoked ≥25 cigarettes per day. Smoking also impacts on the clinical severity of psoriasis, its response to treatment, and explains some of the associated comorbidities, eg, cardiovascular disease, inflammatory bowel disease, and several cancers (especially those of the respiratory tract). Data on the role of smoking in psoriatic arthritis are less consistent compared with those concerning psoriasis. Several pathophysiological mechanisms may explain the association of psoriasis with smoking, including oxidative stress, interaction with signaling pathways active in psoriasis, and vascular influences. In conclusion, psoriasis is just one of the many diseases associated with smoking, but it is visible and disabling. Dermatologists could play a major role in reducing the health burden of smoking by influencing the patients to change their behavior. Keywords: smoking, nicotine dependence, risk, psoriasis, onset, prognosis, comorbiditiesNaldi LDove Medical Pressarticlesmokingnicotine dependenceriskpsoriasisonsetprognosisco-morbiditiesDermatologyRL1-803ENPsoriasis: Targets and Therapy, Vol 2016, Iss Issue 1, Pp 65-71 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	smoking nicotine dependence risk psoriasis onset prognosis co-morbidities Dermatology RL1-803
spellingShingle	smoking nicotine dependence risk psoriasis onset prognosis co-morbidities Dermatology RL1-803 Naldi L Psoriasis and smoking: links and risks
description	Luigi Naldi1,2 1Department of Dermatology, Azienda Ospedaliera Papa Giovanni XXIII, Bergamo, Italy; 2Study Centre of the Italian Group for Epidemiologic Research in Dermatology (GISED), Bergamo, Italy Abstract: Smoking is a complex environmental exposure influenced by genetic, environmental, and social factors. Nicotine is the principal alkaloid in tobacco that mediates the addicting effects of tobacco products. Tobacco is a mixture of more than 7,000 chemicals, and smoking is recognized as a risk factor for many diseases in humans, including cardiovascular and pulmonary disease and several cancers, and is the single most preventable cause of mortality worldwide. A number of inflammatory immune-related conditions have been associated with smoking, including psoriasis. Smoking affects the onset of psoriasis. In a pooled analysis of 25 case–control studies, the odds ratio of psoriasis among smokers was 1.78 (95% confidence interval [CI]: 1.53–2.06). A dose–effect relationship is also documented. In a pooled analysis of three cohort studies, the risk of incident psoriasis was 1.81 (95% CI: 1.38–2.36) in those who smoked 1–14 cigarettes per day, and 2.29 (95% CI: 1.74–3.01) in those who smoked ≥25 cigarettes per day. Smoking also impacts on the clinical severity of psoriasis, its response to treatment, and explains some of the associated comorbidities, eg, cardiovascular disease, inflammatory bowel disease, and several cancers (especially those of the respiratory tract). Data on the role of smoking in psoriatic arthritis are less consistent compared with those concerning psoriasis. Several pathophysiological mechanisms may explain the association of psoriasis with smoking, including oxidative stress, interaction with signaling pathways active in psoriasis, and vascular influences. In conclusion, psoriasis is just one of the many diseases associated with smoking, but it is visible and disabling. Dermatologists could play a major role in reducing the health burden of smoking by influencing the patients to change their behavior. Keywords: smoking, nicotine dependence, risk, psoriasis, onset, prognosis, comorbidities
format	article
author	Naldi L
author_facet	Naldi L
author_sort	Naldi L
title	Psoriasis and smoking: links and risks
title_short	Psoriasis and smoking: links and risks
title_full	Psoriasis and smoking: links and risks
title_fullStr	Psoriasis and smoking: links and risks
title_full_unstemmed	Psoriasis and smoking: links and risks
title_sort	psoriasis and smoking: links and risks
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/1298604327ab4c00beaaf727e22b61c9
work_keys_str_mv	AT naldil psoriasisandsmokinglinksandrisks
_version_	1718403363015491584

Psoriasis and smoking: links and risks

Ejemplares similares