Memory and relatedness of transcriptional activity in mammalian cell lineages

Phenotypically identical mammalian cells often display considerable variability in transcript levels of individual genes. Here the authors document how different genes propagate their expression levels in cell lineages and suggest a potential role of transcriptional memory for generating spatial pat...

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Autores principales:	Nicholas E. Phillips, Aleksandra Mandic, Saeed Omidi, Felix Naef, David M. Suter
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/129c79e594114d3db8f9415be1533700
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spelling	oai:doaj.org-article:129c79e594114d3db8f9415be15337002021-12-02T15:35:27ZMemory and relatedness of transcriptional activity in mammalian cell lineages10.1038/s41467-019-09189-82041-1723https://doaj.org/article/129c79e594114d3db8f9415be15337002019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09189-8https://doaj.org/toc/2041-1723Phenotypically identical mammalian cells often display considerable variability in transcript levels of individual genes. Here the authors document how different genes propagate their expression levels in cell lineages and suggest a potential role of transcriptional memory for generating spatial patterns of gene expression.Nicholas E. PhillipsAleksandra MandicSaeed OmidiFelix NaefDavid M. SuterNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Nicholas E. Phillips Aleksandra Mandic Saeed Omidi Felix Naef David M. Suter Memory and relatedness of transcriptional activity in mammalian cell lineages
description	Phenotypically identical mammalian cells often display considerable variability in transcript levels of individual genes. Here the authors document how different genes propagate their expression levels in cell lineages and suggest a potential role of transcriptional memory for generating spatial patterns of gene expression.
format	article
author	Nicholas E. Phillips Aleksandra Mandic Saeed Omidi Felix Naef David M. Suter
author_facet	Nicholas E. Phillips Aleksandra Mandic Saeed Omidi Felix Naef David M. Suter
author_sort	Nicholas E. Phillips
title	Memory and relatedness of transcriptional activity in mammalian cell lineages
title_short	Memory and relatedness of transcriptional activity in mammalian cell lineages
title_full	Memory and relatedness of transcriptional activity in mammalian cell lineages
title_fullStr	Memory and relatedness of transcriptional activity in mammalian cell lineages
title_full_unstemmed	Memory and relatedness of transcriptional activity in mammalian cell lineages
title_sort	memory and relatedness of transcriptional activity in mammalian cell lineages
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/129c79e594114d3db8f9415be1533700
work_keys_str_mv	AT nicholasephillips memoryandrelatednessoftranscriptionalactivityinmammaliancelllineages AT aleksandramandic memoryandrelatednessoftranscriptionalactivityinmammaliancelllineages AT saeedomidi memoryandrelatednessoftranscriptionalactivityinmammaliancelllineages AT felixnaef memoryandrelatednessoftranscriptionalactivityinmammaliancelllineages AT davidmsuter memoryandrelatednessoftranscriptionalactivityinmammaliancelllineages
_version_	1718386516672118784

Memory and relatedness of transcriptional activity in mammalian cell lineages

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