The Effect of Cerium Oxide on Lung Tissue in Lower Extremity Ischemia Reperfusion Injury in Sevoflurane Administered Rats

Aydin Tuncay,1 Volkan Sivgin,2 Aycan Ozdemirkan,2 Saban Cem Sezen,3 Hakan Boyunaga,4 Aysegul Kucuk,5 Isin Gunes,6 Mustafa Arslan2 1Faculty of Medicine, Department of Cardiovascular Surgery, Erciyes University, Kayseri, Turkey; 2Faculty of Medicine, Department of Anesthesiology and Reamination, Gazi...

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Autores principales:	Tuncay A, Sivgin V, Ozdemirkan A, Sezen SC, Boyunaga H, Kucuk A, Gunes I, Arslan M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	cerium oxide sevoflurane ischemia reperfusion biochemical analysis histopathological analysis Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/12a06e91a72a453ba58e999b65801f13
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spelling	oai:doaj.org-article:12a06e91a72a453ba58e999b65801f132021-12-02T10:35:11ZThe Effect of Cerium Oxide on Lung Tissue in Lower Extremity Ischemia Reperfusion Injury in Sevoflurane Administered Rats1178-2013https://doaj.org/article/12a06e91a72a453ba58e999b65801f132020-10-01T00:00:00Zhttps://www.dovepress.com/the-effect-of-cerium-oxide-on-lung-tissue-in-lower-extremity-ischemia--peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Aydin Tuncay,1 Volkan Sivgin,2 Aycan Ozdemirkan,2 Saban Cem Sezen,3 Hakan Boyunaga,4 Aysegul Kucuk,5 Isin Gunes,6 Mustafa Arslan2 1Faculty of Medicine, Department of Cardiovascular Surgery, Erciyes University, Kayseri, Turkey; 2Faculty of Medicine, Department of Anesthesiology and Reamination, Gazi University, Ankara, Turkey; 3Faculty of Medicine, Department of Histology and Embryology, Kırıkkale University, Kırıkkale, Turkey; 4Faculty of Medicine, Department of Medical Biochemistry, Kırıkkale University, Kırıkkale, Turkey; 5Faculty of Medicine, Department of Physiology, Kütahya Health Science University, Kütahya, Turkey; 6Faculty of Medicine, Department of Anesthesiology and Reamination, Erciyes University, Kayseri, TurkeyCorrespondence: Mustafa Arslan Gazi University, Faculty of MedicineDepartment of Anesthesiology and Reanimation, Ankara 06510, TurkeyTel +90 533 422 85 77Email mustarslan@gmail.comIntroduction: We aimed to investigate the effects of cerium oxide, applied before the sevoflurane anesthesia, on lung tissue in rats with lower extremity ischemia-reperfusion (IR).Materials and Methods: A total of 30 rats were randomly divided into five groups as; control (C), IR, cerium oxide-IR (CO-IR), IR-sevoflurane (IRS), and cerium oxide-IR-sevoflurane (CO-IRS). In the CO-IR group, 30 minutes after the injection of cerium oxide (0.5 mg/kg, intraperitoneal (i.p)), an atraumatic microvascular clamp was placed on the infrarenal abdominal aorta for 120 minutes. Then, the clamp was removed and reperfused for 120 minutes. Sevoflurane was applied in 100% oxygen at a rate of 2.3% at 4 L/min during IR. The blood samples were taken for biochemical analysis and the lung tissue samples were taken for histological analysis.Results: Neutrophil infiltration/aggregation was significantly higher in the IR group than in the C and CO-IRS groups. The alveolar wall thickness and total lung injury scores were significantly higher in the IR group than in the C, IRS, CO-IR and CO-IRS groups.Discussion: We determined that the administration of 0.5 mg/kg dose of cerium oxide with sevoflurane reduces the oxidative stress and corrects IR-related damage in lung tissue. Our results show that the administration of cerium oxide before IR and the administration of sevoflurane during IR have a protective effect in rats.Keywords: cerium oxide, sevoflurane, ischemia reperfusion, biochemical analysis, histopathological analysisTuncay ASivgin VOzdemirkan ASezen SCBoyunaga HKucuk AGunes IArslan MDove Medical Pressarticlecerium oxidesevofluraneischemia reperfusionbiochemical analysishistopathological analysisMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 15, Pp 7481-7489 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	cerium oxide sevoflurane ischemia reperfusion biochemical analysis histopathological analysis Medicine (General) R5-920
spellingShingle	cerium oxide sevoflurane ischemia reperfusion biochemical analysis histopathological analysis Medicine (General) R5-920 Tuncay A Sivgin V Ozdemirkan A Sezen SC Boyunaga H Kucuk A Gunes I Arslan M The Effect of Cerium Oxide on Lung Tissue in Lower Extremity Ischemia Reperfusion Injury in Sevoflurane Administered Rats
description	Aydin Tuncay,1 Volkan Sivgin,2 Aycan Ozdemirkan,2 Saban Cem Sezen,3 Hakan Boyunaga,4 Aysegul Kucuk,5 Isin Gunes,6 Mustafa Arslan2 1Faculty of Medicine, Department of Cardiovascular Surgery, Erciyes University, Kayseri, Turkey; 2Faculty of Medicine, Department of Anesthesiology and Reamination, Gazi University, Ankara, Turkey; 3Faculty of Medicine, Department of Histology and Embryology, Kırıkkale University, Kırıkkale, Turkey; 4Faculty of Medicine, Department of Medical Biochemistry, Kırıkkale University, Kırıkkale, Turkey; 5Faculty of Medicine, Department of Physiology, Kütahya Health Science University, Kütahya, Turkey; 6Faculty of Medicine, Department of Anesthesiology and Reamination, Erciyes University, Kayseri, TurkeyCorrespondence: Mustafa Arslan Gazi University, Faculty of MedicineDepartment of Anesthesiology and Reanimation, Ankara 06510, TurkeyTel +90 533 422 85 77Email mustarslan@gmail.comIntroduction: We aimed to investigate the effects of cerium oxide, applied before the sevoflurane anesthesia, on lung tissue in rats with lower extremity ischemia-reperfusion (IR).Materials and Methods: A total of 30 rats were randomly divided into five groups as; control (C), IR, cerium oxide-IR (CO-IR), IR-sevoflurane (IRS), and cerium oxide-IR-sevoflurane (CO-IRS). In the CO-IR group, 30 minutes after the injection of cerium oxide (0.5 mg/kg, intraperitoneal (i.p)), an atraumatic microvascular clamp was placed on the infrarenal abdominal aorta for 120 minutes. Then, the clamp was removed and reperfused for 120 minutes. Sevoflurane was applied in 100% oxygen at a rate of 2.3% at 4 L/min during IR. The blood samples were taken for biochemical analysis and the lung tissue samples were taken for histological analysis.Results: Neutrophil infiltration/aggregation was significantly higher in the IR group than in the C and CO-IRS groups. The alveolar wall thickness and total lung injury scores were significantly higher in the IR group than in the C, IRS, CO-IR and CO-IRS groups.Discussion: We determined that the administration of 0.5 mg/kg dose of cerium oxide with sevoflurane reduces the oxidative stress and corrects IR-related damage in lung tissue. Our results show that the administration of cerium oxide before IR and the administration of sevoflurane during IR have a protective effect in rats.Keywords: cerium oxide, sevoflurane, ischemia reperfusion, biochemical analysis, histopathological analysis
format	article
author	Tuncay A Sivgin V Ozdemirkan A Sezen SC Boyunaga H Kucuk A Gunes I Arslan M
author_facet	Tuncay A Sivgin V Ozdemirkan A Sezen SC Boyunaga H Kucuk A Gunes I Arslan M
author_sort	Tuncay A
title	The Effect of Cerium Oxide on Lung Tissue in Lower Extremity Ischemia Reperfusion Injury in Sevoflurane Administered Rats
title_short	The Effect of Cerium Oxide on Lung Tissue in Lower Extremity Ischemia Reperfusion Injury in Sevoflurane Administered Rats
title_full	The Effect of Cerium Oxide on Lung Tissue in Lower Extremity Ischemia Reperfusion Injury in Sevoflurane Administered Rats
title_fullStr	The Effect of Cerium Oxide on Lung Tissue in Lower Extremity Ischemia Reperfusion Injury in Sevoflurane Administered Rats
title_full_unstemmed	The Effect of Cerium Oxide on Lung Tissue in Lower Extremity Ischemia Reperfusion Injury in Sevoflurane Administered Rats
title_sort	effect of cerium oxide on lung tissue in lower extremity ischemia reperfusion injury in sevoflurane administered rats
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/12a06e91a72a453ba58e999b65801f13
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The Effect of Cerium Oxide on Lung Tissue in Lower Extremity Ischemia Reperfusion Injury in Sevoflurane Administered Rats

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