A clinically applicable and scalable method to regenerate T-cells from iPSCs for off-the-shelf T-cell immunotherapy

T-cell immunotherapies, such as CAR-T immunotherapy, are being developed against a wide variety of diseases. Here the authors report the feeder-free, scalable differentiation of human induced pluripotent cells (iPSCs) to T-cells with T-cell receptor dependent anti-tumour function in vitro and in viv...

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Autores principales:	Shoichi Iriguchi, Yutaka Yasui, Yohei Kawai, Suguru Arima, Mihoko Kunitomo, Takayuki Sato, Tatsuki Ueda, Atsutaka Minagawa, Yuta Mishima, Nariaki Yanagawa, Yuji Baba, Yasuyuki Miyake, Kazuhide Nakayama, Maiko Takiguchi, Tokuyuki Shinohara, Tetsuya Nakatsura, Masaki Yasukawa, Yoshiaki Kassai, Akira Hayashi, Shin Kaneko
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/12a17ede1fbe4df1bb06b871dd8b9d04
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spelling	oai:doaj.org-article:12a17ede1fbe4df1bb06b871dd8b9d042021-12-02T13:51:03ZA clinically applicable and scalable method to regenerate T-cells from iPSCs for off-the-shelf T-cell immunotherapy10.1038/s41467-020-20658-32041-1723https://doaj.org/article/12a17ede1fbe4df1bb06b871dd8b9d042021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20658-3https://doaj.org/toc/2041-1723T-cell immunotherapies, such as CAR-T immunotherapy, are being developed against a wide variety of diseases. Here the authors report the feeder-free, scalable differentiation of human induced pluripotent cells (iPSCs) to T-cells with T-cell receptor dependent anti-tumour function in vitro and in vivo.Shoichi IriguchiYutaka YasuiYohei KawaiSuguru ArimaMihoko KunitomoTakayuki SatoTatsuki UedaAtsutaka MinagawaYuta MishimaNariaki YanagawaYuji BabaYasuyuki MiyakeKazuhide NakayamaMaiko TakiguchiTokuyuki ShinoharaTetsuya NakatsuraMasaki YasukawaYoshiaki KassaiAkira HayashiShin KanekoNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Shoichi Iriguchi Yutaka Yasui Yohei Kawai Suguru Arima Mihoko Kunitomo Takayuki Sato Tatsuki Ueda Atsutaka Minagawa Yuta Mishima Nariaki Yanagawa Yuji Baba Yasuyuki Miyake Kazuhide Nakayama Maiko Takiguchi Tokuyuki Shinohara Tetsuya Nakatsura Masaki Yasukawa Yoshiaki Kassai Akira Hayashi Shin Kaneko A clinically applicable and scalable method to regenerate T-cells from iPSCs for off-the-shelf T-cell immunotherapy
description	T-cell immunotherapies, such as CAR-T immunotherapy, are being developed against a wide variety of diseases. Here the authors report the feeder-free, scalable differentiation of human induced pluripotent cells (iPSCs) to T-cells with T-cell receptor dependent anti-tumour function in vitro and in vivo.
format	article
author	Shoichi Iriguchi Yutaka Yasui Yohei Kawai Suguru Arima Mihoko Kunitomo Takayuki Sato Tatsuki Ueda Atsutaka Minagawa Yuta Mishima Nariaki Yanagawa Yuji Baba Yasuyuki Miyake Kazuhide Nakayama Maiko Takiguchi Tokuyuki Shinohara Tetsuya Nakatsura Masaki Yasukawa Yoshiaki Kassai Akira Hayashi Shin Kaneko
author_facet	Shoichi Iriguchi Yutaka Yasui Yohei Kawai Suguru Arima Mihoko Kunitomo Takayuki Sato Tatsuki Ueda Atsutaka Minagawa Yuta Mishima Nariaki Yanagawa Yuji Baba Yasuyuki Miyake Kazuhide Nakayama Maiko Takiguchi Tokuyuki Shinohara Tetsuya Nakatsura Masaki Yasukawa Yoshiaki Kassai Akira Hayashi Shin Kaneko
author_sort	Shoichi Iriguchi
title	A clinically applicable and scalable method to regenerate T-cells from iPSCs for off-the-shelf T-cell immunotherapy
title_short	A clinically applicable and scalable method to regenerate T-cells from iPSCs for off-the-shelf T-cell immunotherapy
title_full	A clinically applicable and scalable method to regenerate T-cells from iPSCs for off-the-shelf T-cell immunotherapy
title_fullStr	A clinically applicable and scalable method to regenerate T-cells from iPSCs for off-the-shelf T-cell immunotherapy
title_full_unstemmed	A clinically applicable and scalable method to regenerate T-cells from iPSCs for off-the-shelf T-cell immunotherapy
title_sort	clinically applicable and scalable method to regenerate t-cells from ipscs for off-the-shelf t-cell immunotherapy
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/12a17ede1fbe4df1bb06b871dd8b9d04
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_version_	1718392421583159296

A clinically applicable and scalable method to regenerate T-cells from iPSCs for off-the-shelf T-cell immunotherapy

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