Role of Pretreatment Hemoglobin-to-Platelet Ratio in Predicting Survival Outcome of Locally Advanced Nasopharyngeal Carcinoma Patients

Background. The three-year survival rate of locally advanced nasopharyngeal carcinoma (NPC) patients in Indonesia is lower than in other Asian countries. Calculation of hemoglobin-to-platelet ratio (HPR) may become a more practical predictor than the ratios using leukocyte cell components. Yet, no s...

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Autores principales:	Cosphiadi Irawan, Andhika Rachman, Puji Rahman, Arif Mansjoer
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Medicine R
Acceso en línea:	https://doaj.org/article/12a243c074b34dcab75e50f784c268c7
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spelling	oai:doaj.org-article:12a243c074b34dcab75e50f784c268c72021-11-08T02:37:21ZRole of Pretreatment Hemoglobin-to-Platelet Ratio in Predicting Survival Outcome of Locally Advanced Nasopharyngeal Carcinoma Patients1687-856610.1155/2021/1103631https://doaj.org/article/12a243c074b34dcab75e50f784c268c72021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/1103631https://doaj.org/toc/1687-8566Background. The three-year survival rate of locally advanced nasopharyngeal carcinoma (NPC) patients in Indonesia is lower than in other Asian countries. Calculation of hemoglobin-to-platelet ratio (HPR) may become a more practical predictor than the ratios using leukocyte cell components. Yet, no study has been conducted to investigate the potential of HPR in predicting survival outcomes in locally advanced nasopharyngeal cancer patients. Objective. To determine the role of pretreatment hemoglobin-to-platelet ratio in predicting the three-year overall survival (OS) of locally advanced NPC. Method. A retrospective cohort study followed up on 289 locally advanced NPC patients who had undergone therapy at the Dr. Cipto Mangunkusumo National General Hospital between January 2012 and October 2016. HPR cut-off was determined using ROC. Subjects were classified into two groups according to the HPR value. Kaplan-Meier curve was utilized to illustrate patients’ three-year survival, and Cox regression test analyzed confounding variables to yield an adjusted hazard ratio (HR). Results. The optimal cut-off for HPR was 0.362 (AUC 0.6228, 95% CI: 0.56-0.69, sensitivity 61.27%, specificity 60.34%). Of the subjects, 48.44% had HPR≤0.362, and they had a higher three-year mortality rate than those with HPR>0.362 (50% vs. 31.54%). In bivariate analysis, HPR≤0.362 and age≥60 significantly showed a worse three-year OS (p value = 0.003 and 0.075, respectively). In multivariate analysis, we concluded that a pretreatment HPR≤0.362 was an independent negative predictor of three-year OS in locally advanced NPC patients (adjusted HR 1.82; 95% CI: 1.25–2.65). Conclusion. Pretreatment HPR≤0.362 was a negative predictor of three-year OS in locally advanced nasopharyngeal cancer patients.Cosphiadi IrawanAndhika RachmanPuji RahmanArif MansjoerHindawi LimitedarticleMedicineRENJournal of Cancer Epidemiology, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R
spellingShingle	Medicine R Cosphiadi Irawan Andhika Rachman Puji Rahman Arif Mansjoer Role of Pretreatment Hemoglobin-to-Platelet Ratio in Predicting Survival Outcome of Locally Advanced Nasopharyngeal Carcinoma Patients
description	Background. The three-year survival rate of locally advanced nasopharyngeal carcinoma (NPC) patients in Indonesia is lower than in other Asian countries. Calculation of hemoglobin-to-platelet ratio (HPR) may become a more practical predictor than the ratios using leukocyte cell components. Yet, no study has been conducted to investigate the potential of HPR in predicting survival outcomes in locally advanced nasopharyngeal cancer patients. Objective. To determine the role of pretreatment hemoglobin-to-platelet ratio in predicting the three-year overall survival (OS) of locally advanced NPC. Method. A retrospective cohort study followed up on 289 locally advanced NPC patients who had undergone therapy at the Dr. Cipto Mangunkusumo National General Hospital between January 2012 and October 2016. HPR cut-off was determined using ROC. Subjects were classified into two groups according to the HPR value. Kaplan-Meier curve was utilized to illustrate patients’ three-year survival, and Cox regression test analyzed confounding variables to yield an adjusted hazard ratio (HR). Results. The optimal cut-off for HPR was 0.362 (AUC 0.6228, 95% CI: 0.56-0.69, sensitivity 61.27%, specificity 60.34%). Of the subjects, 48.44% had HPR≤0.362, and they had a higher three-year mortality rate than those with HPR>0.362 (50% vs. 31.54%). In bivariate analysis, HPR≤0.362 and age≥60 significantly showed a worse three-year OS (p value = 0.003 and 0.075, respectively). In multivariate analysis, we concluded that a pretreatment HPR≤0.362 was an independent negative predictor of three-year OS in locally advanced NPC patients (adjusted HR 1.82; 95% CI: 1.25–2.65). Conclusion. Pretreatment HPR≤0.362 was a negative predictor of three-year OS in locally advanced nasopharyngeal cancer patients.
format	article
author	Cosphiadi Irawan Andhika Rachman Puji Rahman Arif Mansjoer
author_facet	Cosphiadi Irawan Andhika Rachman Puji Rahman Arif Mansjoer
author_sort	Cosphiadi Irawan
title	Role of Pretreatment Hemoglobin-to-Platelet Ratio in Predicting Survival Outcome of Locally Advanced Nasopharyngeal Carcinoma Patients
title_short	Role of Pretreatment Hemoglobin-to-Platelet Ratio in Predicting Survival Outcome of Locally Advanced Nasopharyngeal Carcinoma Patients
title_full	Role of Pretreatment Hemoglobin-to-Platelet Ratio in Predicting Survival Outcome of Locally Advanced Nasopharyngeal Carcinoma Patients
title_fullStr	Role of Pretreatment Hemoglobin-to-Platelet Ratio in Predicting Survival Outcome of Locally Advanced Nasopharyngeal Carcinoma Patients
title_full_unstemmed	Role of Pretreatment Hemoglobin-to-Platelet Ratio in Predicting Survival Outcome of Locally Advanced Nasopharyngeal Carcinoma Patients
title_sort	role of pretreatment hemoglobin-to-platelet ratio in predicting survival outcome of locally advanced nasopharyngeal carcinoma patients
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/12a243c074b34dcab75e50f784c268c7
work_keys_str_mv	AT cosphiadiirawan roleofpretreatmenthemoglobintoplateletratioinpredictingsurvivaloutcomeoflocallyadvancednasopharyngealcarcinomapatients AT andhikarachman roleofpretreatmenthemoglobintoplateletratioinpredictingsurvivaloutcomeoflocallyadvancednasopharyngealcarcinomapatients AT pujirahman roleofpretreatmenthemoglobintoplateletratioinpredictingsurvivaloutcomeoflocallyadvancednasopharyngealcarcinomapatients AT arifmansjoer roleofpretreatmenthemoglobintoplateletratioinpredictingsurvivaloutcomeoflocallyadvancednasopharyngealcarcinomapatients
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Role of Pretreatment Hemoglobin-to-Platelet Ratio in Predicting Survival Outcome of Locally Advanced Nasopharyngeal Carcinoma Patients

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