Loss of POMC-mediated antinociception contributes to painful diabetic neuropathy

Proopiomelanocortin is an anti-nociceptive peptide. Here the authors show in a mouse model of diabetes, that this peptide is downregulated, which may contribute to the neuropathic pain like behaviour in these models.

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Autores principales:	Divija Deshpande, Nitin Agarwal, Thomas Fleming, Claire Gaveriaux-Ruff, Christoph S. N. Klose, Anke Tappe-Theodor, Rohini Kuner, Peter Nawroth
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/12a337286d664718a2106d167beb41bd
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spelling	oai:doaj.org-article:12a337286d664718a2106d167beb41bd2021-12-02T10:49:08ZLoss of POMC-mediated antinociception contributes to painful diabetic neuropathy10.1038/s41467-020-20677-02041-1723https://doaj.org/article/12a337286d664718a2106d167beb41bd2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20677-0https://doaj.org/toc/2041-1723Proopiomelanocortin is an anti-nociceptive peptide. Here the authors show in a mouse model of diabetes, that this peptide is downregulated, which may contribute to the neuropathic pain like behaviour in these models.Divija DeshpandeNitin AgarwalThomas FlemingClaire Gaveriaux-RuffChristoph S. N. KloseAnke Tappe-TheodorRohini KunerPeter NawrothNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Divija Deshpande Nitin Agarwal Thomas Fleming Claire Gaveriaux-Ruff Christoph S. N. Klose Anke Tappe-Theodor Rohini Kuner Peter Nawroth Loss of POMC-mediated antinociception contributes to painful diabetic neuropathy
description	Proopiomelanocortin is an anti-nociceptive peptide. Here the authors show in a mouse model of diabetes, that this peptide is downregulated, which may contribute to the neuropathic pain like behaviour in these models.
format	article
author	Divija Deshpande Nitin Agarwal Thomas Fleming Claire Gaveriaux-Ruff Christoph S. N. Klose Anke Tappe-Theodor Rohini Kuner Peter Nawroth
author_facet	Divija Deshpande Nitin Agarwal Thomas Fleming Claire Gaveriaux-Ruff Christoph S. N. Klose Anke Tappe-Theodor Rohini Kuner Peter Nawroth
author_sort	Divija Deshpande
title	Loss of POMC-mediated antinociception contributes to painful diabetic neuropathy
title_short	Loss of POMC-mediated antinociception contributes to painful diabetic neuropathy
title_full	Loss of POMC-mediated antinociception contributes to painful diabetic neuropathy
title_fullStr	Loss of POMC-mediated antinociception contributes to painful diabetic neuropathy
title_full_unstemmed	Loss of POMC-mediated antinociception contributes to painful diabetic neuropathy
title_sort	loss of pomc-mediated antinociception contributes to painful diabetic neuropathy
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/12a337286d664718a2106d167beb41bd
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Loss of POMC-mediated antinociception contributes to painful diabetic neuropathy

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