PREDICTION OF A COURSE OF CHRONIC SUPPURATIVE OTITIS MEDIA BY THE ANALYSIS OF COMBINATIONS OF GENE POLYMORPHISMS OF PROINFLAMMATORY AND ANTI-INFLAMMATORY CYTOKINES

The urgency of otogenic intracranial complications in modern otolaryngology is connected with difficulties of the early diagnostics, severe course of the disease and rather high percentage of fatalities. All of that defines practical value of the matters aimed to improve definition of an individual&...

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Autor principal:	E. V. Bayke
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2017
Materias:	gene polymorphism chronic suppurative otitis media prediction Science Q
Acceso en línea:	https://doaj.org/article/12a5222f213044a496feedf5d2c3b19b
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spelling	oai:doaj.org-article:12a5222f213044a496feedf5d2c3b19b2021-11-23T06:14:37ZPREDICTION OF A COURSE OF CHRONIC SUPPURATIVE OTITIS MEDIA BY THE ANALYSIS OF COMBINATIONS OF GENE POLYMORPHISMS OF PROINFLAMMATORY AND ANTI-INFLAMMATORY CYTOKINES2541-94202587-959610.12737/article_5955e6b406d894.91027165https://doaj.org/article/12a5222f213044a496feedf5d2c3b19b2017-02-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/353https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596The urgency of otogenic intracranial complications in modern otolaryngology is connected with difficulties of the early diagnostics, severe course of the disease and rather high percentage of fatalities. All of that defines practical value of the matters aimed to improve definition of an individual's liability to aggressive course of chronic suppurative otitis media, which can cause direct threat for a patient's life. The aim of the study was to increase accuracy of diagnostics of destructive course of chronic suppurative otitis media with forecasting of intracranial pathology at early stages of inflammation. Molecular genetic analysis was conducted of human DNA from 300 patients with chronic purulent otitis media and 100 healthy individuals for the presence of genotype variants of genes cytokines: IL-1b (511Т/С, 31 Т/C), IL-10 (1082 G/A, 819 С/Т). The SNP (single nucleotide polymorphism) distribution of gene cytokines in the studied groups corresponded Hardy-Weinberg equilibrium (HWE > 0.05). We found that a combination of genes IL-1b 511Т/С, IL-10 1082A/A, IL-10 819С/С, IL-1b 31C/C occurred correspondingly in 57.8,13.6 and 22 % of patients with attic disease, and were associated with expressed caries-destructive course of chronic suppurative otitis media complicated by intracranial pathology. The combination of gene polymorphisms of IL-1b 511 Т/Т, IL-10 1082 G/A, IL-10 819 С/T, IL-1b 31 T/C in 46 % of patients was clinically manifested by mucosal process in the middle ear.E. V. BaykeScientific Сentre for Family Health and Human Reproduction Problemsarticlegene polymorphismchronic suppurative otitis mediapredictionScienceQRUActa Biomedica Scientifica, Vol 2, Iss 1, Pp 12-15 (2017)
institution	DOAJ
collection	DOAJ
language	RU
topic	gene polymorphism chronic suppurative otitis media prediction Science Q
spellingShingle	gene polymorphism chronic suppurative otitis media prediction Science Q E. V. Bayke PREDICTION OF A COURSE OF CHRONIC SUPPURATIVE OTITIS MEDIA BY THE ANALYSIS OF COMBINATIONS OF GENE POLYMORPHISMS OF PROINFLAMMATORY AND ANTI-INFLAMMATORY CYTOKINES
description	The urgency of otogenic intracranial complications in modern otolaryngology is connected with difficulties of the early diagnostics, severe course of the disease and rather high percentage of fatalities. All of that defines practical value of the matters aimed to improve definition of an individual's liability to aggressive course of chronic suppurative otitis media, which can cause direct threat for a patient's life. The aim of the study was to increase accuracy of diagnostics of destructive course of chronic suppurative otitis media with forecasting of intracranial pathology at early stages of inflammation. Molecular genetic analysis was conducted of human DNA from 300 patients with chronic purulent otitis media and 100 healthy individuals for the presence of genotype variants of genes cytokines: IL-1b (511Т/С, 31 Т/C), IL-10 (1082 G/A, 819 С/Т). The SNP (single nucleotide polymorphism) distribution of gene cytokines in the studied groups corresponded Hardy-Weinberg equilibrium (HWE > 0.05). We found that a combination of genes IL-1b 511Т/С, IL-10 1082A/A, IL-10 819С/С, IL-1b 31C/C occurred correspondingly in 57.8,13.6 and 22 % of patients with attic disease, and were associated with expressed caries-destructive course of chronic suppurative otitis media complicated by intracranial pathology. The combination of gene polymorphisms of IL-1b 511 Т/Т, IL-10 1082 G/A, IL-10 819 С/T, IL-1b 31 T/C in 46 % of patients was clinically manifested by mucosal process in the middle ear.
format	article
author	E. V. Bayke
author_facet	E. V. Bayke
author_sort	E. V. Bayke
title	PREDICTION OF A COURSE OF CHRONIC SUPPURATIVE OTITIS MEDIA BY THE ANALYSIS OF COMBINATIONS OF GENE POLYMORPHISMS OF PROINFLAMMATORY AND ANTI-INFLAMMATORY CYTOKINES
title_short	PREDICTION OF A COURSE OF CHRONIC SUPPURATIVE OTITIS MEDIA BY THE ANALYSIS OF COMBINATIONS OF GENE POLYMORPHISMS OF PROINFLAMMATORY AND ANTI-INFLAMMATORY CYTOKINES
title_full	PREDICTION OF A COURSE OF CHRONIC SUPPURATIVE OTITIS MEDIA BY THE ANALYSIS OF COMBINATIONS OF GENE POLYMORPHISMS OF PROINFLAMMATORY AND ANTI-INFLAMMATORY CYTOKINES
title_fullStr	PREDICTION OF A COURSE OF CHRONIC SUPPURATIVE OTITIS MEDIA BY THE ANALYSIS OF COMBINATIONS OF GENE POLYMORPHISMS OF PROINFLAMMATORY AND ANTI-INFLAMMATORY CYTOKINES
title_full_unstemmed	PREDICTION OF A COURSE OF CHRONIC SUPPURATIVE OTITIS MEDIA BY THE ANALYSIS OF COMBINATIONS OF GENE POLYMORPHISMS OF PROINFLAMMATORY AND ANTI-INFLAMMATORY CYTOKINES
title_sort	prediction of a course of chronic suppurative otitis media by the analysis of combinations of gene polymorphisms of proinflammatory and anti-inflammatory cytokines
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2017
url	https://doaj.org/article/12a5222f213044a496feedf5d2c3b19b
work_keys_str_mv	AT evbayke predictionofacourseofchronicsuppurativeotitismediabytheanalysisofcombinationsofgenepolymorphismsofproinflammatoryandantiinflammatorycytokines
_version_	1718416992486031360

PREDICTION OF A COURSE OF CHRONIC SUPPURATIVE OTITIS MEDIA BY THE ANALYSIS OF COMBINATIONS OF GENE POLYMORPHISMS OF PROINFLAMMATORY AND ANTI-INFLAMMATORY CYTOKINES

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