Genome-wide Association Studies for Female Fertility Traits in Chinese and Nordic Holsteins

Abstract Reduced female fertility could cause considerable economic loss and has become a worldwide problem in the modern dairy industry. The objective of this study was to detect quantitative trait loci (QTL) for female fertility traits in Chinese and Nordic Holsteins using various strategies. Firs...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Aoxing Liu, Yachun Wang, Goutam Sahana, Qin Zhang, Lin Liu, Mogens Sandø Lund, Guosheng Su
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/12a7226aa4d44c7f83aea2a6013e4b0c
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:12a7226aa4d44c7f83aea2a6013e4b0c
record_format	dspace
spelling	oai:doaj.org-article:12a7226aa4d44c7f83aea2a6013e4b0c2021-12-02T12:32:37ZGenome-wide Association Studies for Female Fertility Traits in Chinese and Nordic Holsteins10.1038/s41598-017-09170-92045-2322https://doaj.org/article/12a7226aa4d44c7f83aea2a6013e4b0c2017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-09170-9https://doaj.org/toc/2045-2322Abstract Reduced female fertility could cause considerable economic loss and has become a worldwide problem in the modern dairy industry. The objective of this study was to detect quantitative trait loci (QTL) for female fertility traits in Chinese and Nordic Holsteins using various strategies. First, single-trait association analyses were performed for female fertility traits in Chinese and Nordic Holsteins. Second, the SNPs with P-value < 0.005 discovered in Chinese Holsteins were validated in Nordic Holsteins. Third, the summary statistics from single-trait association analyses were combined into meta-analyses to: (1) identify common QTL for multiple fertility traits within each Holstein population; (2) detect SNPs which were associated with a female fertility trait across two Holstein populations. A large numbers of QTL were discovered or confirmed for female fertility traits. The QTL segregating at 31.4~34.1 Mb on BTA13, 48.3~51.9 Mb on BTA23 and 34.0~37.6 Mb on BTA28 shared between Chinese and Nordic Holsteins were further ascertained using a validation approach and meta-analyses. Furthermore, multiple novel variants identified in Chinese Holsteins were validated with Nordic data as well as meta-analyses. The genes IL6R, SLC39A12, CACNB2, ZEB1, ZMIZ1 and FAM213A were concluded to be strong candidate genes for female fertility in Holsteins.Aoxing LiuYachun WangGoutam SahanaQin ZhangLin LiuMogens Sandø LundGuosheng SuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Aoxing Liu Yachun Wang Goutam Sahana Qin Zhang Lin Liu Mogens Sandø Lund Guosheng Su Genome-wide Association Studies for Female Fertility Traits in Chinese and Nordic Holsteins
description	Abstract Reduced female fertility could cause considerable economic loss and has become a worldwide problem in the modern dairy industry. The objective of this study was to detect quantitative trait loci (QTL) for female fertility traits in Chinese and Nordic Holsteins using various strategies. First, single-trait association analyses were performed for female fertility traits in Chinese and Nordic Holsteins. Second, the SNPs with P-value < 0.005 discovered in Chinese Holsteins were validated in Nordic Holsteins. Third, the summary statistics from single-trait association analyses were combined into meta-analyses to: (1) identify common QTL for multiple fertility traits within each Holstein population; (2) detect SNPs which were associated with a female fertility trait across two Holstein populations. A large numbers of QTL were discovered or confirmed for female fertility traits. The QTL segregating at 31.4~34.1 Mb on BTA13, 48.3~51.9 Mb on BTA23 and 34.0~37.6 Mb on BTA28 shared between Chinese and Nordic Holsteins were further ascertained using a validation approach and meta-analyses. Furthermore, multiple novel variants identified in Chinese Holsteins were validated with Nordic data as well as meta-analyses. The genes IL6R, SLC39A12, CACNB2, ZEB1, ZMIZ1 and FAM213A were concluded to be strong candidate genes for female fertility in Holsteins.
format	article
author	Aoxing Liu Yachun Wang Goutam Sahana Qin Zhang Lin Liu Mogens Sandø Lund Guosheng Su
author_facet	Aoxing Liu Yachun Wang Goutam Sahana Qin Zhang Lin Liu Mogens Sandø Lund Guosheng Su
author_sort	Aoxing Liu
title	Genome-wide Association Studies for Female Fertility Traits in Chinese and Nordic Holsteins
title_short	Genome-wide Association Studies for Female Fertility Traits in Chinese and Nordic Holsteins
title_full	Genome-wide Association Studies for Female Fertility Traits in Chinese and Nordic Holsteins
title_fullStr	Genome-wide Association Studies for Female Fertility Traits in Chinese and Nordic Holsteins
title_full_unstemmed	Genome-wide Association Studies for Female Fertility Traits in Chinese and Nordic Holsteins
title_sort	genome-wide association studies for female fertility traits in chinese and nordic holsteins
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/12a7226aa4d44c7f83aea2a6013e4b0c
work_keys_str_mv	AT aoxingliu genomewideassociationstudiesforfemalefertilitytraitsinchineseandnordicholsteins AT yachunwang genomewideassociationstudiesforfemalefertilitytraitsinchineseandnordicholsteins AT goutamsahana genomewideassociationstudiesforfemalefertilitytraitsinchineseandnordicholsteins AT qinzhang genomewideassociationstudiesforfemalefertilitytraitsinchineseandnordicholsteins AT linliu genomewideassociationstudiesforfemalefertilitytraitsinchineseandnordicholsteins AT mogenssandølund genomewideassociationstudiesforfemalefertilitytraitsinchineseandnordicholsteins AT guoshengsu genomewideassociationstudiesforfemalefertilitytraitsinchineseandnordicholsteins
_version_	1718394022083428352

Genome-wide Association Studies for Female Fertility Traits in Chinese and Nordic Holsteins

Ejemplares similares