Tcf3 represses Wnt-β-catenin signaling and maintains neural stem cell population during neocortical development.

Tcf3 represses Wnt-β-catenin signaling and maintains neural stem cell population during neocortical development.

During mouse neocortical development, the Wnt-β-catenin signaling pathway plays essential roles in various phenomena including neuronal differentiation and proliferation of neural precursor cells (NPCs). Production of the appropriate number of neurons without depletion of the NPC population requires...

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Main Authors: Atsushi Kuwahara, Hiroshi Sakai, Yuanjiang Xu, Yasuhiro Itoh, Yusuke Hirabayashi, Yukiko Gotoh
Format: article
Language:EN
Published: Public Library of Science (PLoS) 2014
Subjects:
Medicine
R
Science
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Online Access:https://doaj.org/article/12ac6a25b7bb462b87318339e1d1d35d
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