Kidney intercalated cells are phagocytic and acidify internalized uropathogenic Escherichia coli

Kidney intercalated cells are involved in acid-base homeostasis in the kidneys. Here, the authors use single cell transcriptomics and find that interalated cells exhibit a transcriptional response conducive to defense and can engulf and acidify internalized bacteria, similarly to professional phagoc...

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Autores principales: Vijay Saxena, Hongyu Gao, Samuel Arregui, Amy Zollman, Malgorzata Maria Kamocka, Xiaoling Xuei, Patrick McGuire, Michael Hutchens, Takashi Hato, David S. Hains, Andrew L. Schwaderer
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/12b0361daf0f4717825e3b4c2f6ce834
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Sumario:Kidney intercalated cells are involved in acid-base homeostasis in the kidneys. Here, the authors use single cell transcriptomics and find that interalated cells exhibit a transcriptional response conducive to defense and can engulf and acidify internalized bacteria, similarly to professional phagocytes.