Kidney intercalated cells are phagocytic and acidify internalized uropathogenic Escherichia coli

Kidney intercalated cells are involved in acid-base homeostasis in the kidneys. Here, the authors use single cell transcriptomics and find that interalated cells exhibit a transcriptional response conducive to defense and can engulf and acidify internalized bacteria, similarly to professional phagoc...

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Autores principales:	Vijay Saxena, Hongyu Gao, Samuel Arregui, Amy Zollman, Malgorzata Maria Kamocka, Xiaoling Xuei, Patrick McGuire, Michael Hutchens, Takashi Hato, David S. Hains, Andrew L. Schwaderer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/12b0361daf0f4717825e3b4c2f6ce834
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spelling	oai:doaj.org-article:12b0361daf0f4717825e3b4c2f6ce8342021-12-02T13:39:46ZKidney intercalated cells are phagocytic and acidify internalized uropathogenic Escherichia coli10.1038/s41467-021-22672-52041-1723https://doaj.org/article/12b0361daf0f4717825e3b4c2f6ce8342021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22672-5https://doaj.org/toc/2041-1723Kidney intercalated cells are involved in acid-base homeostasis in the kidneys. Here, the authors use single cell transcriptomics and find that interalated cells exhibit a transcriptional response conducive to defense and can engulf and acidify internalized bacteria, similarly to professional phagocytes.Vijay SaxenaHongyu GaoSamuel ArreguiAmy ZollmanMalgorzata Maria KamockaXiaoling XueiPatrick McGuireMichael HutchensTakashi HatoDavid S. HainsAndrew L. SchwadererNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Vijay Saxena Hongyu Gao Samuel Arregui Amy Zollman Malgorzata Maria Kamocka Xiaoling Xuei Patrick McGuire Michael Hutchens Takashi Hato David S. Hains Andrew L. Schwaderer Kidney intercalated cells are phagocytic and acidify internalized uropathogenic Escherichia coli
description	Kidney intercalated cells are involved in acid-base homeostasis in the kidneys. Here, the authors use single cell transcriptomics and find that interalated cells exhibit a transcriptional response conducive to defense and can engulf and acidify internalized bacteria, similarly to professional phagocytes.
format	article
author	Vijay Saxena Hongyu Gao Samuel Arregui Amy Zollman Malgorzata Maria Kamocka Xiaoling Xuei Patrick McGuire Michael Hutchens Takashi Hato David S. Hains Andrew L. Schwaderer
author_facet	Vijay Saxena Hongyu Gao Samuel Arregui Amy Zollman Malgorzata Maria Kamocka Xiaoling Xuei Patrick McGuire Michael Hutchens Takashi Hato David S. Hains Andrew L. Schwaderer
author_sort	Vijay Saxena
title	Kidney intercalated cells are phagocytic and acidify internalized uropathogenic Escherichia coli
title_short	Kidney intercalated cells are phagocytic and acidify internalized uropathogenic Escherichia coli
title_full	Kidney intercalated cells are phagocytic and acidify internalized uropathogenic Escherichia coli
title_fullStr	Kidney intercalated cells are phagocytic and acidify internalized uropathogenic Escherichia coli
title_full_unstemmed	Kidney intercalated cells are phagocytic and acidify internalized uropathogenic Escherichia coli
title_sort	kidney intercalated cells are phagocytic and acidify internalized uropathogenic escherichia coli
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/12b0361daf0f4717825e3b4c2f6ce834
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Kidney intercalated cells are phagocytic and acidify internalized uropathogenic Escherichia coli

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